ENSMUSG00000046822


Mus musculus

Features
Gene ID: ENSMUSG00000046822
  
Biological name :Slc39a3
  
Synonyms : Mus musculus solute carrier family 39 (zinc transporter), member 3 (Slc39a3), transcript variant 2, mRNA. / Q99K24 / Slc39a3
  
Possible biological names infered from orthology : Q9BRY0 / solute carrier family 39 member 3
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 81028538
Gene end: 81037426
  
Corresponding Affymetrix probe sets: 10371037 (MoGene1.0st)   1417881_at (Mouse Genome 430 2.0 Array)   1417882_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057094
Ensembl peptide - ENSMUSP00000113147
Ensembl peptide - ENSMUSP00000128256
NCBI entrez gene - 106947     See in Manteia.
MGI - MGI:2147269
RefSeq - XM_011243260
RefSeq - NM_001358898
RefSeq - NM_134135
RefSeq - XM_006513026
RefSeq - XM_006513027
RefSeq - XM_011243259
RefSeq - XM_006513024
RefSeq - XM_006513025
RefSeq Peptide - NP_598896
RefSeq Peptide - NP_001345827
swissprot - Q99K24
Ensembl - ENSMUSG00000046822
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLC39A3ENSGALG00000020582Gallus gallus
 Q9BRY0ENSG00000141873Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9QZ03 / Slc39a1 / Zinc transporter ZIP1 / Q9NY26* / solute carrier family 39 member 1*ENSMUSG0000005231031
Slc39a2 / solute carrier family 39 member 2 / Q9NP94*ENSMUSG0000007257228


Protein motifs (from Interpro)
Interpro ID Name
 IPR003689  Zinc/iron permease


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006829 zinc ion transport IEA
 biological_processGO:0030001 metal ion transport IEA
 biological_processGO:0043029 T cell homeostasis IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IGI
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060173 limb development IGI
 biological_processGO:0071577 zinc ion transmembrane transport IEA
 cellular_componentGO:0016020 membrane IBA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005385 zinc ion transmembrane transporter activity IDA
 molecular_functionGO:0046873 metal ion transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Zinc influx into cells by the SLC39 gene family


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001208 blistering "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039]
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Allelic Composition: Slc39a1tm1.1Gka/Slc39a1tm1.1Gka,Slc39a3tm1.1Gka/Slc39a3tm1.1Gka
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc39a1tm1.1Gka/Slc39a1tm1.1Gka,Slc39a3tm1.1Gka/Slc39a3tm1.1Gka
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002436 abnormal cytotoxic T cell morphology/development "anomalous structure, formation, or numbers of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aestm1Grid/Aestm1Grid,Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aestm1Grid/Aestm1Grid,Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc39a1tm1.1Gka/Slc39a1tm1.1Gka,Slc39a3tm1.1Gka/Slc39a3tm1.1Gka
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc39a1tm1.1Gka/Slc39a1tm1.1Gka,Slc39a3tm1.1Gka/Slc39a3tm1.1Gka
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Aestm1Grid/Aestm1Grid,Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc39a1tm1.1Gka/Slc39a1tm1.1Gka,Slc39a3tm1.1Gka/Slc39a3tm1.1Gka
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aestm1Grid/Aestm1Grid,Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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