ENSMUSG00000047443


Mus musculus

Features
Gene ID: ENSMUSG00000047443
  
Biological name :Erfe
  
Synonyms : Erfe / Erythroferrone / Q6PGN1
  
Possible biological names infered from orthology : Q4G0M1
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: D
Gene start: 91366430
Gene end: 91374217
  
Corresponding Affymetrix probe sets: 10348590 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000084073
Ensembl peptide - ENSMUSP00000140509
NCBI entrez gene - 227358     See in Manteia.
MGI - MGI:3606476
RefSeq - XM_006529487
RefSeq - NM_173395
RefSeq - XM_006529484
RefSeq - XM_006529485
RefSeq Peptide - NP_775571
swissprot - A0A087WR80
swissprot - Q6PGN1
Ensembl - ENSMUSG00000047443
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch1073-184j22.1ENSDARG00000055498Danio rerio
 ERFEENSG00000178752Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8R2Z0 / C1qtnf12 / C1q and tumor necrosis factor related 12 / Q5T7M4* / C1q and TNF related 12*ENSMUSG0000002357129


Protein motifs (from Interpro)
Interpro ID Name
 IPR001073  C1q domain
 IPR008983  Tumour necrosis factor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006879 cellular iron ion homeostasis IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019217 regulation of fatty acid metabolic process IDA
 biological_processGO:2000193 positive regulation of fatty acid transport IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Erfetm1Lex/Erfe+
Genetic Background: B6;129S5-Erfetm1Lex/Mmucd

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Erfetm1Lex/Erfetm1Lex,Hbb-b1tm1Unc/Hbb-b1+,Hbb-b2tm1Unc/Hbb-b2+
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Erfetm1Lex/Erfe+
Genetic Background: B6;129S5-Erfetm1Lex/Mmucd

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Erfetm1Lex/Erfetm1Lex,Hbb-b1tm1Unc/Hbb-b1+,Hbb-b2tm1Unc/Hbb-b2+
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

 MP:0004151 hypoferremia "less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Erfetm1Lex/Erfetm1Lex,Hbb-b1tm1Unc/Hbb-b1+,Hbb-b2tm1Unc/Hbb-b2+
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Erfetm1Lex/Erfetm1Lex,Hbb-b1tm1Unc/Hbb-b1+,Hbb-b2tm1Unc/Hbb-b2+
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0008743 decreased liver iron level "reduction in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Erfetm1Lex/Erfetm1Lex,Hbb-b1tm1Unc/Hbb-b1+,Hbb-b2tm1Unc/Hbb-b2+
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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