ENSMUSG00000047617


Mus musculus

Features
Gene ID: ENSMUSG00000047617
  
Biological name :Paxx
  
Synonyms : Paxx / Protein PAXX / Q8K0Y7
  
Possible biological names infered from orthology : PAXX, non-homologous end joining factor / Q9BUH6
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 25455141
Gene end: 25461094
  
Corresponding Affymetrix probe sets: 10480725 (MoGene1.0st)   1442351_a_at (Mouse Genome 430 2.0 Array)   1455596_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109899
Ensembl peptide - ENSMUSP00000120533
NCBI entrez gene - 227622     See in Manteia.
MGI - MGI:2442831
RefSeq - XM_017317186
RefSeq - NM_153557
RefSeq - XM_006497866
RefSeq - XM_006497867
RefSeq - XM_017317185
RefSeq - XM_006497862
RefSeq - XM_006497864
RefSeq - XM_006497865
RefSeq Peptide - NP_705785
swissprot - Q8K0Y7
swissprot - A2AJ30
Ensembl - ENSMUSG00000047617
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 paxxENSDARG00000078807Danio rerio
 PAXXENSG00000148362Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR027873  Protein PAXX


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0051103 DNA ligation involved in DNA repair IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0035861 site of double-strand break IEA
 cellular_componentGO:0043564 Ku70:Ku80 complex IEA
 cellular_componentGO:0070419 nonhomologous end joining complex IEA
 molecular_functionGO:0032947 protein-containing complex scaffold activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0000705 athymia "absence of the primary lymphoid organ" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0000726 absent lymphocyte "lack of specific white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
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Allelic Composition: Ank3tm2.1Bnt/Ank3tm2.1Bnt,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL/J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001824 abnormal thymic involution "premature or late decline in thymic function normally associated with advancing age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Awb/Atmtm1Awb,Paxxem1Spj/Paxxem1Spj
Genetic Background: involves: A/J * C57BL/6NTac

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ank3tm2.1Bnt/Ank3tm2.1Bnt,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL/J

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Paxxem1Spj/Paxxem1Spj
Genetic Background: involves: A/J * C57BL/6NTac

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ank3tm2.1Bnt/Ank3tm2.1Bnt,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL/J

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Paxxem1Spj/Paxxem1Spj
Genetic Background: involves: A/J * C57BL/6NTac

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ank3tm2.1Bnt/Ank3tm2.1Bnt,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL/J

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ank3tm2.1Bnt/Ank3tm2.1Bnt,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL/J

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ank3tm2.1Bnt/Ank3tm2.1Bnt,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL/J

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ank3tm2.1Bnt/Ank3tm2.1Bnt,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL/J

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Ank3tm2.1Bnt/Ank3tm2.1Bnt,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL/J

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Paxxem1Spj/Paxxem1Spj
Genetic Background: C57BL/6NTac-Paxxem1Spj

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Paxxem1Spj/Paxxem1Spj
Genetic Background: involves: A/J * C57BL/6NTac

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Paxxem1Spj/Paxxem1Spj,Xrcc5tm1Nus/Xrcc5tm1Nus
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nhej1tm1Fwa/Nhej1tm1Fwa,Xrcc5tm1Nus/Xrcc5tm1Nus
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0012505 increased neural tube apoptosis "increase in the number of cells of the neural tube undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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