ENSMUSG00000048077


Mus musculus

Features
Gene ID: ENSMUSG00000048077
  
Biological name :H1fnt
  
Synonyms : H1fnt / Q8CJI4 / Testis-specific H1 histone
  
Possible biological names infered from orthology : H1 histone family member N, testis specific / Q75WM6
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F1
Gene start: 98255986
Gene end: 98257293
  
Corresponding Affymetrix probe sets: 10432135 (MoGene1.0st)   1430181_at (Mouse Genome 430 2.0 Array)   1441954_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127616
NCBI entrez gene - 70069     See in Manteia.
MGI - MGI:1917319
RefSeq - NM_027304
RefSeq Peptide - NP_081580
swissprot - Q8CJI4
Ensembl - ENSMUSG00000048077
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 H1FNTENSG00000187166Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006997 nucleus organization TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007290 spermatid nucleus elongation IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030261 chromosome condensation TAS
 biological_processGO:0035092 sperm chromatin condensation IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: H1fnttm1Yoni/H1fnttm1Yoni
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: C57BL/6-Il4tm1Nnt/J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: C57BL/6-Il4tm1Nnt/J

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: C57BL/6-Il4tm1Nnt/J

Allelic Composition: H1fnttm1Yoni/H1fnttm1Yoni
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: C57BL/6-Il4tm1Nnt/J

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: H1fnttm1Yoni/H1fnttm1Yoni
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: H1fnttm1Yoni/H1fnttm1Yoni
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: C57BL/6-Il4tm1Nnt/J

 MP:0009231 detached acrosome "detachment or loss of adhesion of the acrosome cap from the sperm head nucleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: C57BL/6-Il4tm1Nnt/J

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: C57BL/6-Il4tm1Nnt/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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