ENSMUSG00000048163


Mus musculus

Features
Gene ID: ENSMUSG00000048163
  
Biological name :Selplg
  
Synonyms : selectin, platelet (p-selectin) ligand / Selplg
  
Possible biological names infered from orthology : Q14242 / selectin P ligand
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 113818536
Gene end: 113832644
  
Corresponding Affymetrix probe sets: 10532744 (MoGene1.0st)   1449127_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000098436
Ensembl peptide - ENSMUSP00000144450
Ensembl peptide - ENSMUSP00000144186
Ensembl peptide - ENSMUSP00000143912
Ensembl peptide - ENSMUSP00000143052
NCBI entrez gene - 20345     See in Manteia.
MGI - MGI:106689
RefSeq - XM_006530229
RefSeq - NM_009151
RefSeq Peptide - NP_033177
swissprot - A0A0G2JF74
swissprot - A0A0J9YUH7
swissprot - A0A0J9YV23
swissprot - Q3TA56
swissprot - A0A0J9YTY7
Ensembl - ENSMUSG00000048163
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 selplgENSDARG00000105023Danio rerio
 Q14242ENSG00000110876Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026195  P-selectin glycoprotein ligand 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0030246 carbohydrate binding IEA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Relatm1.2Gho/Relatm1.2Gho,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Selplgtm1Rpmc/Selplgtm1Rpmc
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Faslpr/Faslpr,Selplgtm1Fur/Selplgtm1Fur
Genetic Background: MRL.Cg-Selplgtm1Fur Faslpr

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plectm5Gwi/Plectm5Gwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Selplgtm1Fur/Selplgtm1Fur
Genetic Background: MRL.Cg-Selplgtm1Fur Faslpr

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Selplgtm1Rpmc/Selplgtm1Rpmc
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Selplgtm1Rpmc/Selplgtm1Rpmc
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Selplgtm1Rpmc/Selplgtm1Rpmc
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Selplgtm1Rpmc/Selplgtm1Rpmc
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Selplgtm2Rpmc/Selplgtm2Rpmc
Genetic Background: B6.Cg-Selplgtm2Rpmc

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Faslpr/Faslpr,Selplgtm1Fur/Selplgtm1Fur
Genetic Background: MRL.Cg-Selplgtm1Fur Faslpr

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Selplgtm1Rpmc/Selplgtm1Rpmc
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0020332 impaired leukocyte tethering or rolling "reduced ability or inability in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Selplgtm1Rpmc/Selplgtm1Rpmc
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Selplgtm2Rpmc/Selplgtm2Rpmc
Genetic Background: B6.Cg-Selplgtm2Rpmc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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