ENSMUSG00000048240


Mus musculus

Features
Gene ID: ENSMUSG00000048240
  
Biological name :Gng7
  
Synonyms : Gng7 / guanine nucleotide binding protein (G protein), gamma 7 / Q61016
  
Possible biological names infered from orthology : G protein subunit gamma 7 / O60262
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 80948624
Gene end: 81014945
  
Corresponding Affymetrix probe sets: 10371025 (MoGene1.0st)   1455190_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122735
Ensembl peptide - ENSMUSP00000114003
Ensembl peptide - ENSMUSP00000089936
Ensembl peptide - ENSMUSP00000097061
Ensembl peptide - ENSMUSP00000112409
Ensembl peptide - ENSMUSP00000113798
NCBI entrez gene - 14708     See in Manteia.
MGI - MGI:95787
RefSeq - NM_010319
RefSeq - NM_001038655
RefSeq Peptide - NP_001033744
RefSeq Peptide - NP_034449
swissprot - Q61016
swissprot - D3Z483
swissprot - G3X9Q2
swissprot - Q3UGN1
Ensembl - ENSMUSG00000048240
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gng7ENSDARG00000038693Danio rerio
 GNG7ENSGALG00000031980Gallus gallus
 GNG7ENSG00000176533Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gng12 / Q9DAS9 / guanine nucleotide binding protein (G protein), gamma 12 / Q9UBI6* / G protein subunit gamma 12*ENSMUSG0000003640275
Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*ENSMUSG0000004300467
Gm5741 / G protein subunit gamma 14 / GNG14* / A0A1W2PPG7*ENSMUSG0000009584561
Gng4 / P50153 / guanine nucleotide binding protein (G protein), gamma 4 / P50150* / G protein subunit gamma 4*ENSMUSG0000002130359
Gng3 / P63216 / guanine nucleotide binding protein (G protein), gamma 3 / P63215* / G protein subunit gamma 3*ENSMUSG0000007165859
Gng10 / Q9CXP8 / guanine nucleotide binding protein (G protein), gamma 10 / P50151* / G protein subunit gamma 10*ENSMUSG0000003860751
Gng5 / Q80SZ7 / guanine nucleotide binding protein (G protein), gamma 5 / P63218* / G protein subunit gamma 5*ENSMUSG0000006852351
Gng8 / P63078 / guanine nucleotide binding protein (G protein), gamma 8 / Q9UK08* / G protein subunit gamma 8*ENSMUSG0000006359449


Protein motifs (from Interpro)
Interpro ID Name
 IPR001770  G-protein, gamma subunit
 IPR015898  G-protein gamma-like domain
 IPR036284  G-protein gamma-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007168 receptor guanylyl cyclase signaling pathway IMP
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0045761 regulation of adenylate cyclase activity IMP
 cellular_componentGO:0005834 heterotrimeric G-protein complex IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA


Pathways (from Reactome)
Pathway description
Activation of G protein gated Potassium channels
Glucagon signaling in metabolic regulation
G-protein activation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Glucagon-type ligand receptors
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Tyrc-p/Tyrc-p
Genetic Background: involves: AKR/J * DBA/2J

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Tyrc-p/Tyrc-p
Genetic Background: involves: AKR/J * DBA/2J

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx4tm1Pa/Tbx4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrc-p/Tyrc-p
Genetic Background: involves: AKR/J * DBA/2J

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lclat1tm1Arai/Lclat1tm1Arai
Genetic Background: C57BL/6-Lclat1tm1Arai

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbx4tm1Pa/Tbx4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lclat1tm1Arai/Lclat1tm1Arai
Genetic Background: C57BL/6-Lclat1tm1Arai

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Tyrc-p/Tyrc-p
Genetic Background: involves: AKR/J * DBA/2J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Tyrc-p/Tyrc-p
Genetic Background: involves: AKR/J * DBA/2J

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Tbx4tm1Pa/Tbx4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gng3tm1.1Rbs/Gng3tm1.1Rbs,Gng7tm1Lex/Gng7tm1Lex
Genetic Background: B6.Cg-Gng7tm1Lex Gng3tm1.1Rbs

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gng3tm1.1Rbs/Gng3tm1.1Rbs,Gng7tm1Lex/Gng7tm1Lex
Genetic Background: B6.Cg-Gng7tm1Lex Gng3tm1.1Rbs

 MP:0008462 abnormal medium spiny neuron morphology "any structural anomaly of the inhibitory projection neurons located in the striatum that integrate glutamatergic signals arising from the cerebral cortex and thalamus" [PMID:15504319]
Show

Allelic Composition: Tyrc-p/Tyrc-p
Genetic Background: involves: AKR/J * DBA/2J

 MP:0009358 environmentally induced seizures "relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gng3tm1.1Rbs/Gng3tm1.1Rbs,Gng7tm1Lex/Gng7tm1Lex
Genetic Background: B6.Cg-Gng7tm1Lex Gng3tm1.1Rbs

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrc-p/Tyrc-p
Genetic Background: involves: AKR/J * DBA/2J

Allelic Composition: Drd1tm1.1Mmsh/Drd1tm1.1Mmsh,Gng7tm1(cre)Mmsh/?
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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