ENSMUSG00000048752


Mus musculus

Features
Gene ID: ENSMUSG00000048752
  
Biological name :Prss50
  
Synonyms : Probable threonine protease PRSS50 / Prss50 / Q8BLH5
  
Possible biological names infered from orthology : Q9UI38 / serine protease 50
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F2
Gene start: 110857967
Gene end: 110864629
  
Corresponding Affymetrix probe sets: 10589647 (MoGene1.0st)   1439739_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143092
Ensembl peptide - ENSMUSP00000059668
NCBI entrez gene - 235631     See in Manteia.
MGI - MGI:2447303
RefSeq - NM_146227
RefSeq - XM_006512099
RefSeq Peptide - NP_666339
swissprot - A0A0G2JFA6
swissprot - Q8BLH5
Ensembl - ENSMUSG00000048752
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRSS50ENSG00000283706Homo sapiens
 PRSS50ENSG00000206549Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tpsab1 / tryptase alpha/beta 1 / TPSB2* / TPSD1* / Q15661* / P20231* / Q9BZJ3* / tryptase delta 1* / tryptase beta 2 (gene/pseudogene)*ENSMUSG0000002417322
Tpsb2 / TPSD1* / Q9BZJ3* / TPSAB1* / P20231* / Q15661* / tryptase delta 1* / tryptase alpha/beta 1* / tryptase beta 2 (gene/pseudogene)*ENSMUSG0000003382521
Prss46 / Q5M8S2 / Serine protease 46 ENSMUSG0000004971920
Prss29ENSMUSG0000003403919
Prss34 / protease, serine 34ENSMUSG0000005639919
Prss28ENSMUSG0000002417117


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0004298 threonine-type endopeptidase activity ISO
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr