ENSMUSG00000048982


Mus musculus
hormonesignalingGphb5receptorregulationpathwayactivitybetasubunitextracellulargonadotropinglycoproteincystine-knotcytokinethyroidmediatedcellsurfaceg-proteincoupledcell-cellobsoletecampbiosyntheticprocessregionspacecytoplasmthyrotropin-releasingbindingprotein

Features
Gene ID: ENSMUSG00000048982
  
Biological name :Gphb5
  
Synonyms : glycoprotein hormone beta 5 / Gphb5 / Q812B2
  
Possible biological names infered from orthology : Q86YW7
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C3
Gene start: 75411722
Gene end: 75416781
  
Corresponding Affymetrix probe sets: 10401002 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000061488
NCBI entrez gene - 217674     See in Manteia.
MGI - MGI:2156540
RefSeq - XM_017315024
RefSeq - NM_175644
RefSeq Peptide - NP_783575
swissprot - Q812B2
swissprot - B2RTN6
Ensembl - ENSMUSG00000048982
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gphb5ENSDARG00000027472Danio rerio
 GPHB5ENSGALG00000028839Gallus gallus
 GPHB5ENSG00000179600Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001545  Gonadotropin, beta subunit
 IPR006208  Glycoprotein hormone subunit beta
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
cell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusregulation of molecular functioncell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusregulation of molecular functioncell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusregulation of molecular functioncell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusregulation of molecular functioncell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusregulation of molecular functioncell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusregulation of molecular functioncell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusregulation of molecular functioncell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusregulation of molecular functioncell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusregulation of molecular functioncell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimulusregulation of molecular functioncell communicationcell communicationresponse to endogenous stimuresponse to endogenous stimulusresponse to chemicalresponse to chemicalcellular response to stimulucellular response to stimulusregulation of molecular funcregulation of molecular function
protein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingprotein bindingreceptor regulator activityreceptor regulator activity
extracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regionextracellular regioncellcell
TypeGO IDTermEv.Code
 biological_processGO:0002155 regulation of thyroid hormone mediated signaling pathway IMP
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030819 obsolete positive regulation of cAMP biosynthetic process ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0005179 hormone activity IBA
 molecular_functionGO:0031531 thyrotropin-releasing hormone receptor binding ISO
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Hormone ligand-binding receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grm5tm1Fcq/Grm5tm1Fcq
Genetic Background: Not Specified

Allelic Composition: Gphb5tm1Lex/Gphb5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024784 Gpha2 / Q925Q5 / glycoprotein hormone alpha 2 / Q96T91*  / complex
 ENSMUSG00000020963 Tshr / P47750 / thyroid stimulating hormone receptor / P16473*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr