ENSMUSG00000049093


Mus musculus

Features
Gene ID: ENSMUSG00000049093
  
Biological name :Il23r
  
Synonyms : Il23r / interleukin 23 receptor
  
Possible biological names infered from orthology : Q5VWK5
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C1
Gene start: 67422932
Gene end: 67491855
  
Corresponding Affymetrix probe sets: 10545154 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000113342
NCBI entrez gene - 209590     See in Manteia.
MGI - MGI:2181693
RefSeq - NM_144548
RefSeq Peptide - NP_653131
swissprot - G5E8U4
Ensembl - ENSMUSG00000049093
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il23rENSDARG00000052158Danio rerio
 IL23RENSG00000162594Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002230 positive regulation of defense response to virus by host IEA
 biological_processGO:0002827 positive regulation of T-helper 1 type immune response IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032693 negative regulation of interleukin-10 production IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0032735 positive regulation of interleukin-12 production IEA
 biological_processGO:0034341 response to interferon-gamma IEA
 biological_processGO:0038155 interleukin-23-mediated signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0072536 interleukin-23 receptor complex IEA
 molecular_functionGO:0005143 interleukin-12 receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042019 interleukin-23 binding IEA
 molecular_functionGO:0042020 interleukin-23 receptor activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-23 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Taar1m1J/Taar1+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Agtpbp1pcd/Agtpbp1pcd
Genetic Background: involves: C57BL/6J * C57BR/cdJ * DBA/2J

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxc4tm1Mrc/Hoxc4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Taar1m1J/Taar1+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxc4tm1Mrc/Hoxc4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Il23rtm1.1Kuch/Il23rtm1.1Kuch
Genetic Background: involves: C57BL/6

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxc4tm1Mrc/Hoxc4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkralear-2J/Prkralear-2J
Genetic Background: involves: C57BL/6J

 MP:0008588 abnormal circulating interleukin level "anomaly in the amount in the blood of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Prkralear-2J/Prkralear-2J
Genetic Background: involves: C57BL/6J

Allelic Composition: IL-23RIl23rtm1.1Ngh/IL-23RIl23rtm1.1Ngh,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008614 increased circulating interleukin-17 level "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Prkralear-2J/Prkralear-2J
Genetic Background: involves: C57BL/6J

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: IL-23RIl23rtm1.1Ngh/IL-23RIl23rtm1.1Ngh,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008712 decreased interleukin-9 secretion "reduction in the production or release of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells" [MESH:D12.644.276.374.465.509]
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Allelic Composition: Il23rtm1.1Kuch/Il23rtm1.1Kuch
Genetic Background: involves: C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkralear-2J/Prkralear-2J
Genetic Background: involves: C57BL/6J

 MP:0013956 decreased colon length "reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]
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Allelic Composition: IL-23RIl23rtm1.1Ngh/IL-23RIl23rtm1.1Ngh,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000791 Q60837 / Il12rb1 / Interleukin-12 receptor subunit beta-1 / P42701*  / complex
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex
 ENSMUSG00000062939 Stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex
 ENSMUSG00000025383 Il23a / Q9EQ14 / Interleukin-23 subunit alpha / Q9NPF7*  / complex
 ENSMUSG00000004296 Il12b / P43432 / Interleukin-12 subunit beta / P29460* / interleukin 12B*  / complex






 

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