ENSMUSG00000049307


Mus musculus

Features
Gene ID: ENSMUSG00000049307
  
Biological name :Fut4
  
Synonyms : Alpha-(1,3)-fucosyltransferase 4 / Fut4 / Q11127
  
Possible biological names infered from orthology : fucosyltransferase 4 / P22083
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A2
Gene start: 14748320
Gene end: 14752393
  
Corresponding Affymetrix probe sets: 10590957 (MoGene1.0st)   1450834_at (Mouse Genome 430 2.0 Array)   1455843_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053027
NCBI entrez gene - 14345     See in Manteia.
MGI - MGI:95594
RefSeq - NM_010242
RefSeq Peptide - NP_034372
swissprot - Q11127
swissprot - Q544B8
Ensembl - ENSMUSG00000049307
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FUT4ENSGALG00000022718Gallus gallus
 FUT4ENSG00000196371Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fut7 / Q11131 / Alpha-(1,3)-fucosyltransferase 7 / Q11130* / fucosyltransferase 7*ENSMUSG0000003658734
Fut9 / O88819 / Alpha-(1,3)-fucosyltransferase 9 / Q9Y231* / fucosyltransferase 9*ENSMUSG0000005537334
Fut11 / Q8BHC9 / Alpha-(1,3)-fucosyltransferase 11 / Q495W5* / fucosyltransferase 11*ENSMUSG0000003935720
Fut10 / Q5F2L2 / Alpha-(1,3)-fucosyltransferase 10 / Q6P4F1* / fucosyltransferase 10*ENSMUSG0000004615220


Protein motifs (from Interpro)
Interpro ID Name
 IPR001503  Glycosyl transferase family 10
 IPR031481  Fucosyltransferase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0036065 fucosylation IEA
 cellular_componentGO:0000139 Golgi membrane IBA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032580 Golgi cisterna membrane IEA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0008417 fucosyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0046920 alpha-(1->3)-fucosyltransferase activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl
Genetic Background: B6.129S2-Fut4tm1Jbl

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

 MP:0002345 abnormal lymph node primary follicle "anomaly in the immunologically inactive B cell area of the lymph node cortex" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Olig1tm1(cre)Rth/Olig1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
Show

Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl
Genetic Background: B6.129S2-Fut4tm1Jbl

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

 MP:0020332 impaired leukocyte tethering or rolling "reduced ability or inability in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl
Genetic Background: B6.129S2-Fut4tm1Jbl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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