ENSMUSG00000049336


Mus musculus
domainmembraneTenm2egf-likeintegralcomponentvisualydrepeatcarboxypeptidase-likeregulatorysuperfamilyteneurinintracellularn-terminalsix-bladedbeta-propellertolb-likeconservedsiterhsrepeat-associatedcoreteneurin-tox-ghhsignaltransductionselfproteolysisplasmacortex

Features
Gene ID: ENSMUSG00000049336
  
Biological name :Tenm2
  
Synonyms : teneurin-2 isoform 2 / Tenm2
  
Possible biological names infered from orthology : Q9NT68 / teneurin transmembrane protein 2
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A5
Gene start: 36006656
Gene end: 37235964
  
Corresponding Affymetrix probe sets: 10385203 (MoGene1.0st)   1420718_at (Mouse Genome 430 2.0 Array)   1432988_at (Mouse Genome 430 2.0 Array)   1454424_at (Mouse Genome 430 2.0 Array)   1457273_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129951
Ensembl peptide - ENSMUSP00000052014
Ensembl peptide - ENSMUSP00000099865
NCBI entrez gene - 23964     See in Manteia.
MGI - MGI:1345184
RefSeq - XM_017314549
RefSeq - XM_006533301
RefSeq - XM_011249009
RefSeq - XM_011249010
RefSeq - XM_017314548
RefSeq - NM_001290702
RefSeq - NM_011856
RefSeq - XM_006533287
RefSeq - XM_006533288
RefSeq - XM_006533289
RefSeq - XM_006533290
RefSeq - XM_006533291
RefSeq - XM_006533292
RefSeq - XM_006533293
RefSeq - XM_006533294
RefSeq - XM_006533295
RefSeq - XM_006533296
RefSeq - XM_006533297
RefSeq - XM_006533298
RefSeq Peptide - NP_035986
RefSeq Peptide - NP_001277631
swissprot - A0A0A0MQB7
swissprot - A0A0A0MQ92
Ensembl - ENSMUSG00000049336
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-12m10.1ENSDARG00000011171Danio rerio
 si:ch211-166i24.1ENSDARG00000090676Danio rerio
 TENM2ENSDARG00000037122Danio rerio
 TENM2ENSGALG00000001768Gallus gallus
 TENM2ENSG00000145934Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tenm3 / teneurin transmembrane protein 3 / Q9P273*ENSMUSG0000003156169
Tenm4 / Q3UHK6 / Teneurin-4 / Q6N022* / teneurin transmembrane protein 4*ENSMUSG0000004807864
Tenm1 / Q9WTS4 / teneurin transmembrane protein 1 / Q9UKZ4*ENSMUSG0000001615056
Vwde / Q6DFV8 / von Willebrand factor D and EGF domains / Q8N2E2*ENSMUSG000000796794
Wif1 / Q9WUA1 / Wnt inhibitory factor 1 / Q9Y5W5*ENSMUSG000000202183


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR006530  YD repeat
 IPR008969  Carboxypeptidase-like, regulatory domain superfamily
 IPR009471  Teneurin intracellular, N-terminal
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013032  EGF-like, conserved site
 IPR022385  Rhs repeat-associated core
 IPR027689  Teneurin-2/3
 IPR028916  Tox-GHH domain


Gene Ontology (GO)
cell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationcell communicationcellular response to stimulucellular response to stimulusnitrogen compound metabolic nitrogen compound metabolic processprimary metabolic processprimary metabolic processorganic substance metabolic organic substance metabolic process
cellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellcellmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0097264 self proteolysis IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
nervous system phenotypevision/eye phenotypenervous system phenotypevision/eye phenotypenervous system phenotypevision/eye phenotypenervous system phenotypevision/eye phenotypenervous system phenotypevision/eye phenotypenervous system phenotypevision/eye phenotypenervous system phenotypevision/eye phenotypenervous system phenotypevision/eye phenotypenervous system phenotypevision/eye phenotypenervous system phenotypevision/eye phenotypenervous system phenotypenervous system phenotypevision/eye phenotypevision/eye phenotype
IDPhenotypeDefinition Genetic BG
 MP:0000805 abnormal visual cortex morphology "malformation or absence of the area of the occipital cortex concerned with vision" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Plvaptm1e(EUCOMM)Hmgu/Plvaptm1e(EUCOMM)Hmgu,Tg(TIE2GFP)287Sato/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0000904 abnormal superior colliculus "dysmorphology or disorganization of the paired superior eminence of the mesencephalic tectum that is involved in auditory processing" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Plvaptm1e(EUCOMM)Hmgu/Plvaptm1e(EUCOMM)Hmgu,Tg(TIE2GFP)287Sato/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
Show

Allelic Composition: Plvaptm1e(EUCOMM)Hmgu/Plvaptm1e(EUCOMM)Hmgu,Tg(TIE2GFP)287Sato/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Plvaptm1e(EUCOMM)Hmgu/Plvaptm1e(EUCOMM)Hmgu,Tg(TIE2GFP)287Sato/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plvaptm1e(EUCOMM)Hmgu/Plvaptm1e(EUCOMM)Hmgu,Tg(TIE2GFP)287Sato/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0004165 abnormal lateral geniculate nucleus morphology "any malformation or absence of the group of neurons that serve as the primary processor of visual information received from the retina via the optic tract and send processed information to the visual cortex of the occipital lobe" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Plvaptm1e(EUCOMM)Hmgu/Plvaptm1e(EUCOMM)Hmgu,Tg(TIE2GFP)287Sato/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0005241 abnormal retinal ganglion layer morphology "anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Plvaptm1e(EUCOMM)Hmgu/Plvaptm1e(EUCOMM)Hmgu,Tg(TIE2GFP)287Sato/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0010748 abnormal visual evoked potential "anomaly in the electroencephalographic pattern recorded from the occipital area generated in response to retinal stimulation such as flashing lights or inverting a contrasting image; may be used to evaluate optic nerve damage or visual perception" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plvaptm1e(EUCOMM)Hmgu/Plvaptm1e(EUCOMM)Hmgu,Tg(TIE2GFP)287Sato/0
Genetic Background: involves: C57BL/6N * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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