ENSMUSG00000049410


Mus musculus

Features
Gene ID: ENSMUSG00000049410
  
Biological name :Zfp683
  
Synonyms : I7HJS4 / Zfp683 / zinc finger protein 683
  
Possible biological names infered from orthology : Q8IZ20 / ZNF683
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 134053838
Gene end: 134058996
  
Corresponding Affymetrix probe sets: 10508909 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000101508
MGI - MGI:3650254
swissprot - I7HJS4
Ensembl - ENSMUSG00000049410
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q8IZ20ENSG00000176083Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prdm1 / Q60636 / PR domain zinc finger protein 1 / O75626* / PR/SET domain 1*ENSMUSG0000003815133


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001779 natural killer cell differentiation IMP
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0032823 regulation of natural killer cell differentiation IMP
 biological_processGO:0032826 regulation of natural killer cell differentiation involved in immune response IMP
 biological_processGO:0033082 regulation of extrathymic T cell differentiation IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0051136 regulation of NK T cell differentiation IMP
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001793 altered susceptibility to infection "a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: F2rtm1Ajc/F2rtm1Ajc,F2rl1tm1Cgh/F2rl1tm1Cgh
Genetic Background: involves: 129S4/SvJae

 MP:0008036 abnormal NK T cell morphology "any structural anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: F2rtm1Ajc/F2rtm1Ajc,F2rl1tm1Cgh/F2rl1tm1Cgh
Genetic Background: involves: 129S4/SvJae

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: F2rtm1Ajc/F2rtm1Ajc,F2rl1tm1Cgh/F2rl1tm1Cgh
Genetic Background: involves: 129S4/SvJae

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: F2rtm1Ajc/F2rtm1Ajc,F2rl1tm1Cgh/F2rl1tm1Cgh
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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