ENSMUSG00000050192


Mus musculus

Features
Gene ID: ENSMUSG00000050192
  
Biological name :Eif5a2
  
Synonyms : Eif5a2 / Eukaryotic translation initiation factor 5A-2 / Q8BGY2
  
Possible biological names infered from orthology : Q9GZV4
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: A3
Gene start: 28781276
Gene end: 28798846
  
Corresponding Affymetrix probe sets: 10491182 (MoGene1.0st)   1434593_at (Mouse Genome 430 2.0 Array)   1438256_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050289
NCBI entrez gene - 208691     See in Manteia.
MGI - MGI:1933735
RefSeq - NM_177586
RefSeq - XM_017319514
RefSeq Peptide - NP_808254
swissprot - Q8BGY2
Ensembl - ENSMUSG00000050192
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif5aENSDARG00000017235Danio rerio
 EIF5A2ENSGALG00000009309Gallus gallus
 EIF5A2ENSG00000163577Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eif5a / P63242 / Eukaryotic translation initiation factor 5A-1 / P63241* / Q6IS14* / EIF5AL1* / eukaryotic translation initiation factor 5A* / eukaryotic translation initiation factor 5A-like 1*ENSMUSG0000007881282


Protein motifs (from Interpro)
Interpro ID Name
 IPR001884  Translation elongation factor IF5A-like
 IPR008991  Translation protein SH3-like domain superfamily
 IPR012340  Nucleic acid-binding, OB-fold
 IPR014722  Ribosomal protein L2, domain 2
 IPR019769  Translation elongation factor, IF5A, hypusine site
 IPR020189  Translation elongation factor, IF5A C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006414 translational elongation IEA
 biological_processGO:0006452 translational frameshifting IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0045901 positive regulation of translational elongation IEA
 biological_processGO:0045905 positive regulation of translational termination IEA
 biological_processGO:0051028 mRNA transport IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003746 translation elongation factor activity IEA
 molecular_functionGO:0043022 ribosome binding IEA


Pathways (from Reactome)
Pathway description
Hypusine synthesis from eIF5A-lysine


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grk1tvrm207/Grk1tvrm207
Genetic Background: B6.Cg-Grk1tvrm207/Pjn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000078440 Dohh / Q99LN9 / Deoxyhypusine hydroxylase / Q9BU89*  / reaction
 ENSMUSG00000060038 Dhps / Q3TXU5 / Deoxyhypusine synthase / P49366*  / reaction






 

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