ENSMUSG00000050321


Mus musculus

Features
Gene ID: ENSMUSG00000050321
  
Biological name :Neto1
  
Synonyms : Neto1 / Neuropilin and tolloid-like protein 1 / Q8R4I7
  
Possible biological names infered from orthology : neuropilin and tolloid like 1 / Q8TDF5
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E4
Gene start: 86394952
Gene end: 86501897
  
Corresponding Affymetrix probe sets: 10457091 (MoGene1.0st)   1425132_at (Mouse Genome 430 2.0 Array)   1456283_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057340
NCBI entrez gene - 246317     See in Manteia.
MGI - MGI:2180216
RefSeq - XM_017317908
RefSeq - NM_144946
RefSeq - XM_006526483
RefSeq - XM_017317907
RefSeq - XM_006526480
RefSeq - XM_006526481
RefSeq - XM_006526482
RefSeq Peptide - NP_659195
swissprot - Q8R4I7
Ensembl - ENSMUSG00000050321
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 neto1ENSDARG00000068483Danio rerio
 neto1lENSDARG00000071596Danio rerio
 NETO1ENSGALG00000041184Gallus gallus
 NETO1ENSG00000166342Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Neto2 / Q8BNJ6 / Mus musculus neuropilin (NRP) and tolloid (TLL)-like 2 (Neto2), transcript variant 1, mRNA. / Q8NC67* / neuropilin and tolloid like 2*ENSMUSG0000003690255
Cubn / Q9JLB4 / Cubilin / O60494*ENSMUSG0000002672622
Bmp1 / P98063 / Bone morphotic protein 1 / P13497* / bone morphogenetic protein 1*ENSMUSG0000002209820
Tll2 / Q9WVM6 / Tolloid-like protein 2 / Q9Y6L7* / tolloid like 2*ENSMUSG0000002501320
Tll1 / tolloid-like / O43897* / tolloid like 1*ENSMUSG0000005362619
Mfrp / Q8K480 / Membrane frizzled-related protein / Q9BY79*ENSMUSG0000003473916
Cdcp2 / Q8BQH6 / CUB domain-containing protein 2 / Q5VXM1*ENSMUSG0000004763615
Q8R4W6 / Pcolce2 / Procollagen C-endopeptidase enhancer 2 / Q9UKZ9*ENSMUSG0000001535413
Pcolce / Q61398 / Procollagen C-endopeptidase enhancer 1 / Q15113* / procollagen C-endopeptidase enhancer*ENSMUSG0000002971812


Protein motifs (from Interpro)
Interpro ID Name
 IPR000859  CUB domain
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR028867  Neuropilin and tolloid-like protein 1
 IPR035914  Spermadhesin, CUB domain superfamily
 IPR036055  LDL receptor-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007613 memory IMP
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0048168 regulation of neuronal synaptic plasticity IEA
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IMP
 biological_processGO:0097120 receptor localization to synapse IMP
 biological_processGO:2000312 regulation of kainate selective glutamate receptor activity IEA
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0060076 excitatory synapse IDA
 cellular_componentGO:0098839 postsynaptic density membrane IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Jmk/Nfatc4tm1Jmk,Tg(Myh6-NFATC4)#Eno/?
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Jmk/Nfatc4tm1Jmk,Tg(Myh6-NFATC4)#Eno/?
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Jmk/Nfatc4tm1Jmk,Tg(Myh6-NFATC4)#Eno/?
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Jmk/Nfatc4tm1Jmk,Tg(Myh6-NFATC4)#Eno/?
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Neto1tm1(KOMP)Vlcg/Neto1tm1(KOMP)Vlcg
Genetic Background: B6.B6NTac-Neto1tm1(KOMP)Vlcg

Allelic Composition: Neto1tm1Mci/Neto1tm1Mci,Neto2tm1Mci/Neto2tm1Mci
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Neto1tm1(KOMP)Vlcg/Neto1tm1(KOMP)Vlcg
Genetic Background: B6.B6NTac-Neto1tm1(KOMP)Vlcg

 MP:0006073 abnormal retinal bipolar cell morphology "anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623:]
Show

Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

 MP:0009244 abnormal acid-activated cation-mediated receptor currents "change in the measured amplitude, current density or duration of response to stimulation of acid-activated cation-mediated receptors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Neto1tm1(KOMP)Vlcg/Neto1tm1(KOMP)Vlcg
Genetic Background: B6.B6NTac-Neto1tm1(KOMP)Vlcg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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