ENSMUSG00000052234


Mus musculus

Features
Gene ID: ENSMUSG00000052234
  
Biological name :Epx
  
Synonyms : Eosinophil peroxidase Eosinophil peroxidase light chain Eosinophil peroxidase heavy chain / Epx / P49290
  
Possible biological names infered from orthology : eosinophil peroxidase / P11678
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: C
Gene start: 87864000
Gene end: 87875536
  
Corresponding Affymetrix probe sets: 10389654 (MoGene1.0st)   1449136_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050497
NCBI entrez gene - 13861     See in Manteia.
MGI - MGI:107569
RefSeq - NM_007946
RefSeq Peptide - NP_031972
swissprot - P49290
Ensembl - ENSMUSG00000052234
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mpxENSDARG00000019521Danio rerio
 ENSGALG00000043254Gallus gallus
 EPXENSG00000121053Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mpo / P11247 / Myeloperoxidase Myeloperoxidase light chain Myeloperoxidase heavy chain / P05164* / myeloperoxidase*ENSMUSG0000000935068
Lpo / lactoperoxidase / P22079*ENSMUSG0000000935649
Tpo / P35419 / thyroid peroxidase / P07202*ENSMUSG0000002067343
Pxdn / Q3UQ28 / Peroxidasin homolog / Q92626* / peroxidasin*ENSMUSG0000002067442


Protein motifs (from Interpro)
Interpro ID Name
 IPR010255  Haem peroxidase
 IPR019791  Haem peroxidase, animal type
 IPR029599  Eosinophil peroxidase
 IPR037120  Haem peroxidase domain superfamily, animal type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002215 defense response to nematode IMP
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0032693 negative regulation of interleukin-10 production IMP
 biological_processGO:0032714 negative regulation of interleukin-5 production IMP
 biological_processGO:0032753 positive regulation of interleukin-4 production IMP
 biological_processGO:0042744 hydrogen peroxide catabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0072677 eosinophil migration IMP
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0004601 peroxidase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Epxtm1.1(cre)Jlee/Epx+,Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005061 abnormal eosinophil morphology "structural anomaly of the granular leukocytes having a two-lobed nucleus and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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