ENSMUSG00000052301


Mus musculus

Features
Gene ID: ENSMUSG00000052301
  
Biological name :Doc2a
  
Synonyms : Doc2a / Double C2-like domain-containing protein alpha / Q7TNF0
  
Possible biological names infered from orthology : double C2 domain alpha / Q14183
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 126847416
Gene end: 126852705
  
Corresponding Affymetrix probe sets: 10557508 (MoGene1.0st)   1436862_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118143
Ensembl peptide - ENSMUSP00000145630
Ensembl peptide - ENSMUSP00000135114
Ensembl peptide - ENSMUSP00000123483
Ensembl peptide - ENSMUSP00000123143
Ensembl peptide - ENSMUSP00000119779
Ensembl peptide - ENSMUSP00000070119
Ensembl peptide - ENSMUSP00000117376
NCBI entrez gene - 13446     See in Manteia.
MGI - MGI:109446
RefSeq - XM_017321971
RefSeq - XM_017321970
RefSeq - XM_017321969
RefSeq - XM_017321968
RefSeq - XM_017321967
RefSeq - XM_017321966
RefSeq - NM_010069
RefSeq Peptide - NP_034199
swissprot - Q7TNF0
swissprot - D3Z1K1
swissprot - H3BJT3
swissprot - A0A0U1RNM8
swissprot - D3YYV2
swissprot - D3YZ51
swissprot - D3Z126
Ensembl - ENSMUSG00000052301
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-93n13.3ENSDARG00000078736Danio rerio
 DOC2AENSG00000149927Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Doc2b / P70169 / Double C2-like domain-containing protein beta / double C2 domain beta*ENSMUSG0000002084863
Rph3a / P47708 / Rabphilin-3A / Q9Y2J0*ENSMUSG0000002960856
Doc2gENSMUSG0000002487149
Sytl4 / Q9R0Q1 / synaptotagmin-like 4 / Q96C24*ENSMUSG0000003125528
Sytl2 / Q99N50 / Synaptotagmin-like protein 2 / Q9HCH5* / synaptotagmin like 2*ENSMUSG0000003061625
Sytl5 / Q80T23 / synaptotagmin-like 5 / Q8TDW5*ENSMUSG0000005445325
Sytl1 / synaptotagmin like 1 / Q8IYJ3*ENSMUSG0000002886024
Sytl3 / Q99N48 / Synaptotagmin-like protein 3 / Q4VX76* / synaptotagmin like 3*ENSMUSG0000004183121


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001565  Synaptotagmin
 IPR014638  Double C2 protein, alpha/beta/gamma
 IPR030535  Double C2-like domain-containing protein alpha
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006906 vesicle fusion IBA
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0016079 synaptic vesicle exocytosis IEA
 biological_processGO:0017158 regulation of calcium ion-dependent exocytosis IEA
 biological_processGO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0070382 exocytic vesicle IBA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IEA
 molecular_functionGO:0019905 syntaxin binding IBA
 molecular_functionGO:0030276 clathrin binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Krt71Rgsc689/?
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002799 abnormal passive avoidance behavior "defects in the ability of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously with prolonged latency" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Krt71Rgsc689/?
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0003990 decreased neurotransmitter release "reduced secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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