ENSMUSG00000052372


Mus musculus

Features
Gene ID: ENSMUSG00000052372
  
Biological name :Il1rapl1
  
Synonyms : Il1rapl1 / interleukin 1 receptor accessory protein like 1
  
Possible biological names infered from orthology : Q9NZN1
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: C1
Gene start: 86740870
Gene end: 88115645
  
Corresponding Affymetrix probe sets: 10605616 (MoGene1.0st)   1453373_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109597
Ensembl peptide - ENSMUSP00000109599
Ensembl peptide - ENSMUSP00000077915
NCBI entrez gene - 331461     See in Manteia.
MGI - MGI:2687319
RefSeq - NM_001160403
RefSeq Peptide - NP_001153875
swissprot - B1ASU0
swissprot - Q0VDP7
Ensembl - ENSMUSG00000052372
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il1rapl1aENSDARG00000062045Danio rerio
 il1rapl1bENSDARG00000104853Danio rerio
 IL1RAPL1ENSGALG00000016288Gallus gallus
 Q9NZN1ENSG00000169306Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9ERS6 / Il1rapl2 / X-linked interleukin-1 receptor accessory protein-like 2 / Q9NP60* / interleukin 1 receptor accessory protein like 2*ENSMUSG0000005920361
Il1rap / Q61730 / Interleukin-1 receptor accessory protein / Q9NPH3*ENSMUSG0000002251427
Il1r1 / P13504 / Interleukin-1 receptor type 1 Interleukin-1 receptor type 1, membrane form Interleukin-1 receptor type 1, soluble form / P14778* / interleukin 1 receptor type 1*ENSMUSG0000002607222
Il1rl1 / P14719 / Interleukin-1 receptor-like 1 / Q01638*ENSMUSG0000002606920
Il18r1 / Q61098 / Interleukin-18 receptor 1 / Q13478*ENSMUSG0000002607020
Il1rl2 / Q9ERS7 / Mus musculus interleukin 1 receptor-like 2 (Il1rl2), transcript variant 2, mRNA. / Q9HB29* / interleukin 1 receptor like 2*ENSMUSG0000007094220
Q9Z2B1 / Il18rap / Interleukin-18 receptor accessory protein / O95256*ENSMUSG0000002606819
Il1r2 / P27931 / Interleukin-1 receptor type 2 Interleukin-1 receptor type 2, membrane form Interleukin-1 receptor type 2, soluble form / P27930* / interleukin 1 receptor type 2*ENSMUSG0000002607312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR015621  Interleukin-1 receptor family
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0045920 negative regulation of exocytosis IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Receptor-type tyrosine-protein phosphatases
Interleukin-38 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Tspan12tm1Wye/Tspan12+
Genetic Background: either: B6.129S5-Tspan12tm1Wye or FVB.129S5-Tspan12tm1Wye

Allelic Composition: Il1rapl1tm1.1Hesk/Y
Genetic Background: involves: C57BL/6

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tspan12tm1Wye/Tspan12+
Genetic Background: either: B6.129S5-Tspan12tm1Wye or FVB.129S5-Tspan12tm1Wye

Allelic Composition: Il1rapl1tm1.1Hesk/Y
Genetic Background: involves: C57BL/6

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Tspan12tm1Wye/Tspan12+
Genetic Background: either: B6.129S5-Tspan12tm1Wye or FVB.129S5-Tspan12tm1Wye

Allelic Composition: Il1rapl1tm1.1Hesk/Y
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000046845 Il1f10 / Q8R459 / Interleukin-1 family member 10 / Q8WWZ1*  / complex / reaction






 

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