ENSMUSG00000052516


Mus musculus

Features
Gene ID: ENSMUSG00000052516
  
Biological name :Robo2
  
Synonyms : Robo2 / roundabout guidance receptor 2
  
Possible biological names infered from orthology : Q9HCK4
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C3.1
Gene start: 73892306
Gene end: 74411825
  
Corresponding Affymetrix probe sets: 10440344 (MoGene1.0st)   1458229_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112285
Ensembl peptide - ENSMUSP00000113795
Ensembl peptide - ENSMUSP00000154010
Ensembl peptide - ENSMUSP00000154353
Ensembl peptide - ENSMUSP00000112776
NCBI entrez gene - 268902     See in Manteia.
MGI - MGI:1890110
RefSeq - XM_017317018
RefSeq - XM_011246131
RefSeq - XM_011246132
RefSeq - XM_017317013
RefSeq - XM_017317015
RefSeq - XM_017317016
RefSeq - XM_017317017
RefSeq - NM_001358490
RefSeq - NM_001358493
RefSeq - NM_175549
RefSeq - XM_006523035
RefSeq - XM_006523036
RefSeq - XM_006523037
RefSeq - XM_006523038
RefSeq - XM_006523039
RefSeq - XM_006523040
RefSeq - XM_006523041
RefSeq - XM_006523042
RefSeq - XM_006523043
RefSeq - XM_006523044
RefSeq - XM_006523045
RefSeq - XM_006523046
RefSeq - XM_006523047
RefSeq - XM_006523048
RefSeq - XM_006523049
RefSeq Peptide - NP_780758
RefSeq Peptide - NP_001345419
RefSeq Peptide - NP_001345422
swissprot - E9Q6A0
swissprot - Q19AB2
swissprot - E9PYK2
Ensembl - ENSMUSG00000052516
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ROBO2ENSGALG00000015519Gallus gallus
 ROBO2ENSG00000185008Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Robo1 / roundabout guidance receptor 1 / Q9Y6N7*ENSMUSG0000002288352
Robo3 / roundabout guidance receptor 3 / Q96MS0*ENSMUSG0000003212840
Robo4 / roundabout guidance receptor 4 / Q8WZ75*ENSMUSG0000003212517
Cdon / Q32MD9 / Cell adhesion molecule-related/down-regulated by oncos / Q4KMG0* / cell adhesion associated, oncogene regulated*ENSMUSG0000003811915
Boc / BOC cell adhesion associated, oncogene regulated / Q9BWV1*ENSMUSG0000002268714
Ncam2 / O35136 / Neural cell adhesion molecule 2 / O15394*ENSMUSG0000002276212
Ncam1 / neural cell adhesion molecule 1 isoform 3 / P13591* / neural cell adhesion molecule 1*ENSMUSG0000003954212


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR032985  Roundabout homologue 2
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001657 ureteric bud development IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0021510 spinal cord development IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0035385 Roundabout signaling pathway IEA
 biological_processGO:0050772 positive regulation of axonogenesis IEA
 biological_processGO:0050925 negative regulation of negative chemotaxis IEA
 biological_processGO:0061364 apoptotic process involved in luteolysis IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030673 axolemma IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008046 axon guidance receptor activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Signaling by ROBO receptors
Regulation of commissural axon pathfinding by SLIT and ROBO


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000474 abnormal foregut morphology "malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802]
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Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Rilm/Robo2tm1Rilm,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129 * 129X1/SvJ

 MP:0000516 abnormal urinary system morphology "structural or developmental anomaly of any of the organs involved in the production or excretion of urine " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Robo2tm1.1Rilm/Robo2tm1.1Rilm
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Robo2tm1.1Rilm/Robo2+,Tg(Hoxb7-EGFP)33Cos/?
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Robo2tm1Rilm/Robo2tm1.1Rilm,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0000534 abnormal ureter morphology "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krt71Rgsc689/?
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Robo2tm1Rilm/Robo2tm1.1Rilm,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Mrt/Robo2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
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Allelic Composition: Six1tm2.2Mair/Six1tm2.2Mair
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Robo2tm1Rilm/Robo2tm1Rilm,Olfr160tm4Mom/?,Omptm1(cre)Jae/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S1/Sv

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Slit2tm1.1Ics/Slit2tm1.1Ics,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Mrt/Robo2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Rilm/Robo2tm1Rilm,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129 * 129X1/SvJ

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Rilm/Robo2tm1Rilm,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129 * 129X1/SvJ

 MP:0002067 abnormal sensory capabilities/reflexes/nociception "inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Six1tm2.2Mair/Six1tm2.2Mair
Genetic Background: involves: C57BL/6NTac

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptch1tm1Mps/Ptch1+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptch1tm1Mps/Ptch1+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Rilm/Robo2tm1Rilm,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129

Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Rilm/Robo2tm1Rilm,Tbx4tm1(cre)Tmj/Tbx4+
Genetic Background: involves: 129

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Rilm/Robo2tm1Rilm,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129

Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Mrt/Robo2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Mrt/Robo2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0002769 abnormal vas deferens morphology "malformation of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Robo2tm1Rilm/Robo2tm1.1Rilm,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gdnftm1Rosl/Gdnf+,Slit2tm1Matl/Slit2tm1Matl
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Robo2tm1Mrt/Robo2tm1Mrt,Robo3tm1Matl/Robo3tm1Matl
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Mrt/Robo2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Mrt/Robo2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0002990 short ureter "reduced length of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptch1tm1Mps/Ptch1+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Allelic Composition: Robo2tm1Rilm/Robo2tm1.1Rilm,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0003585 large ureter "increased size or length of the tube that conducts the urine from the renal pelvis to the bladder" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Robo2tm1Rilm/Robo2tm1.1Rilm,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Robo2tm1.1Rilm/Robo2+,Tg(Hoxb7-EGFP)33Cos/?
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N

 MP:0003586 ureter dilation "abnormal distention of the ureter due to accumulation of fluid" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Robo2tm1.1Rilm/Robo2+,Tg(Hoxb7-EGFP)33Cos/?
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptch1tm1Mps/Ptch1+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Allelic Composition: Robo2tm1Rilm/Robo2tm1.1Rilm,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0003924 herniated diaphragm "protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Rilm/Robo2tm1Rilm,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129 * 129X1/SvJ

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Xisttm1Jae/Xisttm2.1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0004550 short trachea "reduced length of the tube descending from the larynx and branching into the right and left main bronchi" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Mrt/Robo2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Mrt/Robo2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0005237 abnormal olfactory tract morphology "structural anomaly of the nervelike, white band composed primarily of nerve fibers originating from the mitral cells and tufted cells of the olfactory bulb, but also containing the scattered cells of the anterior olfactory nucleus " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34460]
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Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Mrt/Robo2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Robo2tm1Mrt/Robo2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0008219 abnormal dorsal telencephalic commissure morphology "any structural anomaly of the fiber tracts that connect the dorsal region of the two cerebral hemispheres and span the longitudinal fissure, including the corpus callosum and hippocampal commissure" [PMID:16715082]
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Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Mrt/Robo2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0008225 abnormal anterior commissure morphology "any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Mrt/Robo2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
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Allelic Composition: Xisttm1Jae/Xisttm2.1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Robo2tm1Rilm/Robo2tm1Rilm,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Mrt/Robo2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0009678 abnormal spinal cord lateral column morphology "any structural anomaly of the region of white matter of the spinal cord that is located between the dorsal and ventral spinal roots" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gdnftm1Rosl/Gdnf+,Slit2tm1Matl/Slit2tm1Matl
Genetic Background: involves: 129S2/SvPas

 MP:0009695 abnormal spinal cord ventral commissure morphology "any structural anomaly of the band of nerve fibers which cross the midline of the spinal cord ventral to the central canal and posterior grey commissure" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Mrt/Robo2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0009976 abnormal cerebellar peduncle morphology "any structural anomaly of any of the three large paired bundles of nerve fibers that connect the cerebellum to the brain stem" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Rilm/Robo2tm1Rilm,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129

 MP:0010807 abnormal stomach position or orientation "the stomach is displaced from the normal left-sided position and/or orientation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Mrt/Robo2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0010880 small esophagus "reduced size of the part of the digestive canal through which food passes from the pharynx to the stomach" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Mrt/Robo2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Rilm/Robo2tm1Rilm,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129 * 129X1/SvJ

 MP:0010881 esophagus hypoplasia "underdevelopment or decreased size of the esophagus, usually due a reduced number of cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Mrt/Robo2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Krt71Rgsc689/?
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Robo2tm1.1Rilm/Robo2tm1.1Rilm
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Mrt/Robo2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Xisttm1Jae/Xisttm2.1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0011488 abnormal ureterovesical junction morphology "any structural anomaly of the valve-like structure found at the site of entry of the ureter into the urinary bladder, normally displays an oblique angulation through the detrusor to avoid reflux of urine up the ureters and the kidney" [MGI:csmith]
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Allelic Composition: Robo2tm1Rilm/Robo2tm1.1Rilm,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0011492 ureterovesical junction obstruction "a partial or total blockage of the valve-like structure found at the site of entry of the ureter into the urinary bladder" [MGI:anna]
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Allelic Composition: Robo2tm1Rilm/Robo2tm1.1Rilm,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0011805 decreased cell migration "reduced or slower movement of cells from one site to another, often occuring during developmental or chemotactic processes" [GO:0016477, MGI:csmith]
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Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Mrt/Robo2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032128 Robo3 / roundabout guidance receptor 3 / Q96MS0*  / complex






 

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