ENSMUSG00000052942


Mus musculus
rnaiidecreasedpancreaticGlis3transcriptionbindingdnaregulationsequence-specificactivityincreasedcirculatinglevelcellzincfingerproximalpromoterinsulincellschdna-templatedtranscriptionalkidneybodypostnatalrenalbeta

Features
Gene ID: ENSMUSG00000052942
  
Biological name :Glis3
  
Synonyms : Glis3 / Q6XP49 / Zinc finger protein GLIS3
  
Possible biological names infered from orthology : GLIS family zinc finger 3 / Q8NEA6
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C1
Gene start: 28258851
Gene end: 28680077
  
Corresponding Affymetrix probe sets: 10466886 (MoGene1.0st)   10466888 (MoGene1.0st)   1430353_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066953
Ensembl peptide - ENSMUSP00000124635
Ensembl peptide - ENSMUSP00000125721
Ensembl peptide - ENSMUSP00000124823
Ensembl peptide - ENSMUSP00000108231
Ensembl peptide - ENSMUSP00000124143
NCBI entrez gene - 226075     See in Manteia.
MGI - MGI:2444289
RefSeq - XM_006526985
RefSeq - XM_006526984
RefSeq - NM_001305671
RefSeq - NM_175459
RefSeq Peptide - NP_780668
RefSeq Peptide - NP_001292600
swissprot - Q0GE24
swissprot - Q6XP49
swissprot - E0CYJ3
swissprot - E0CX93
Ensembl - ENSMUSG00000052942
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 glis3ENSDARG00000069726Danio rerio
 GLIS3ENSGALG00000010180Gallus gallus
 GLIS3ENSG00000107249Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Glis1 / Q8K1M4 / Zinc finger protein GLIS1 / Q8NBF1* / GLIS family zinc finger 1*ENSMUSG0000003476232
Gli2 / Q0VGT2 / Zinc finger protein GLI2 / P10070* / GLI family zinc finger 2*ENSMUSG0000004840228
Gli3 / Q61602 / Transcriptional activator GLI3 Transcriptional repressor GLI3R / P10071* / GLI family zinc finger 3*ENSMUSG0000002131827
Gli1 / P47806 / Zinc finger protein GLI1 / P08151* / GLI family zinc finger 1*ENSMUSG0000002540720
Glis2 / Q8VDL9 / Zinc finger protein GLIS2 / Q9BZE0* / GLIS family zinc finger 2*ENSMUSG0000001430315
Zic5 / zinc finger protein of the cerebellum 5 / Q96T25* / Zic family member 5*ENSMUSG0000004170315
Zic2 / zinc finger protein of the cerebellum 2 / O95409* / Zic family member 2*ENSMUSG0000006152413
Zic3 / Q62521 / zinc finger protein of the cerebellum 3 / O60481* / Zic family member 3*ENSMUSG0000006786013
Zic1 / P46684 / zinc finger protein of the cerebellum 1 / Q15915* / Zic family member 1*ENSMUSG0000003236812
Zic4 / Q61467 / zinc finger protein of the cerebellum 4 / Q8N9L1* / Zic family member 4*ENSMUSG0000003697210


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR030405  Zinc finger protein GLIS3
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic nitrogen compound metabolic processbiosynthetic processbiosynthetic processcellular metabolic processcellular metabolic processprimary metabolic processprimary metabolic processorganic substance metabolic organic substance metabolic process
organic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityion bindingorganic cyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor acDNA-binding transcription factor activityion bindingion binding
cellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellcellorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
renal/urinary system phenotypegrowth/size phenotypehomeostasis/metabolism phenotypeendocrine/exocrine gland phenotypecellular phenotypemortality/agingrenal/urinary system phenotypegrowth/size phenotypehomeostasis/metabolism phenotypeendocrine/exocrine gland phenotypecellular phenotypemortality/agingrenal/urinary system phenotypegrowth/size phenotypehomeostasis/metabolism phenotypeendocrine/exocrine gland phenotypecellular phenotypemortality/agingrenal/urinary system phenotypegrowth/size phenotypehomeostasis/metabolism phenotypeendocrine/exocrine gland phenotypecellular phenotypemortality/agingrenal/urinary system phenotypegrowth/size phenotypehomeostasis/metabolism phenotypeendocrine/exocrine gland phenotypecellular phenotypemortality/agingrenal/urinary system phenotypegrowth/size phenotypehomeostasis/metabolism phenotypeendocrine/exocrine gland phenotypecellular phenotypemortality/agingrenal/urinary system phenotypegrowth/size phenotypehomeostasis/metabolism phenotypeendocrine/exocrine gland phenotypecellular phenotypemortality/agingrenal/urinary system phenotypegrowth/size phenotypehomeostasis/metabolism phenotypeendocrine/exocrine gland phenotypecellular phenotypemortality/agingrenal/urinary system phenotypegrowth/size phenotypehomeostasis/metabolism phenotypeendocrine/exocrine gland phenotypecellular phenotypemortality/agingrenal/urinary system phenotypegrowth/size phenotypehomeostasis/metabolism phenotypeendocrine/exocrine gland phenotypecellular phenotypemortality/agingrenal/urinary system phrenal/urinary system phenotypegrowth/size phenotypegrowth/size phenotypehomeostasis/metabolism homeostasis/metabolism phenotypeendocrine/exocrine glanendocrine/exocrine gland phenotypecellular phenotypecellular phenotypemortality/agingmortality/aging
IDPhenotypeDefinition Genetic BG
 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
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Allelic Composition: Cebpbtm1.1Acle/Cebpb+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Sh2b3tm1Paw/Sh2b3tm1Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Sh2b3tm1Paw/Sh2b3tm1Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: Not Specified

Allelic Composition: Glis3tm1.2Chan/Glis3tm1.2Chan
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpbtm1.1Acle/Cebpb+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Glis3tm1.2Chan/Glis3tm1.2Chan
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: Not Specified

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
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Allelic Composition: Glis3tm1.2Chan/Glis3tm1.2Chan
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0002693 abnormal pancreas physiology "abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpbtm1.1Acle/Cebpb+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: Not Specified

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Glis3tm1.2Chan/Glis3tm1.2Chan
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

Allelic Composition: Glis3tm1.2Chan/Glis3+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Glis3tm1.2Chan/Glis3tm1.2Chan
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

Allelic Composition: Glis3tm1.2Chan/Glis3+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cebpbtm1.1Acle/Cebpb+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Glis3tm1.2Chan/Glis3tm1.2Chan
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0003503 decreased activity of thyroid 
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Allelic Composition: Cebpbtm1.1Acle/Cebpb+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cebpbtm1.1Acle/Cebpb+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cebpbtm1.1Acle/Cebpb+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Cebpbtm1.1Acle/Cebpb+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Glis3tm1.2Chan/Glis3tm1.2Chan
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: Not Specified

Allelic Composition: Glis3tm1Hiha/Glis3tm1Hiha
Genetic Background: involves: C57BL/6 * CBA

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Glis3tm1Hiha/Glis3tm1Hiha
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Glis3tm1.2Chan/Glis3tm1.2Chan
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0009174 absent pancreatic beta cells "absence of the cells of the pancreas that secrete insulin" [MESH:A03.734.414.131]
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Allelic Composition: Glis3tm1.2Chan/Glis3tm1.2Chan
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0009177 decreased pancreatic alpha cell number "reduction in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
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Allelic Composition: Glis3tm1Hiha/Glis3tm1Hiha
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Glis3tm1.2Chan/Glis3tm1.2Chan
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0009178 absent pancreatic alpha cells "absence of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
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Allelic Composition: Glis3tm1.2Chan/Glis3tm1.2Chan
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0009181 decreased pancreatic delta cell number "reduced number of the cells found in the pancreas that secrete somatostatin" [MESH:A03.556.875.875.440.854]
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Allelic Composition: Glis3tm1Hiha/Glis3tm1Hiha
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Glis3tm1.2Chan/Glis3tm1.2Chan
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0009191 decreased pancreatic epsilon cell number "reduction in the number of the endocrine cells found in the Islets of Langerhans that produce the hormone ghrelin" [PMID:14970313]
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Allelic Composition: Glis3tm1.2Chan/Glis3tm1.2Chan
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0009254 disorganized pancreatic islets "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Glis3tm1.2Chan/Glis3tm1.2Chan
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: Not Specified

 MP:0011066 abnormal renal tubule epithelial cell primary cilium morphology "any structural anomaly of the single non-motile cilium of a renal tubule epithelial cell that projects into the luminal space of the tubules where it is thought to act as a flow sensor" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17995581]
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Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: Not Specified

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: Not Specified

Allelic Composition: Glis3tm1Hiha/Glis3tm1Hiha
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Glis3tm1.2Chan/Glis3tm1.2Chan
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0011501 increased glomerular capsule space "increased volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [MGI:csmith]
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Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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