ENSMUSG00000053164


Mus musculus

Features
Gene ID: ENSMUSG00000053164
  
Biological name :Gpr21
  
Synonyms : Gpr21 / Probable G-protein coupled receptor 21 / Q8BX79
  
Possible biological names infered from orthology : G protein-coupled receptor 21 / Q99679
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 37516332
Gene end: 37520603
  
Corresponding Affymetrix probe sets: 10471814 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000066449
NCBI entrez gene - 338346     See in Manteia.
MGI - MGI:2441890
RefSeq - NM_177383
RefSeq Peptide - NP_796357
swissprot - Q8BX79
Ensembl - ENSMUSG00000053164
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GPR21ENSG00000188394Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007212 dopamine receptor signaling pathway IEA
 biological_processGO:0040018 positive regulation of multicellular organism growth IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm2.1Vpa,Tg(Chat-cre)GM24Gsat/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm2.1Vpa,Tg(Chat-cre)GM24Gsat/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm2.1Vpa,Tg(Chat-cre)GM24Gsat/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm2.1Vpa,Tg(Chat-cre)GM24Gsat/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm2.1Vpa,Tg(Chat-cre)GM24Gsat/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm2.1Vpa,Tg(Chat-cre)GM24Gsat/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N

 MP:0010209 abnormal circulating chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm2.1Vpa,Tg(Chat-cre)GM24Gsat/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N

 MP:0010214 abnormal circulating serum amyloid protein level "deviation from the normal blood levels of an acute-phase reaction protein that is a precursor to amyloid A protein; it is present in very high levels during acute inflammatory episodes, and is present in low concentrations in normal sera, but is found at higher concentrations in sera of older persons and in patients with amyloidosis" [MESH:D12.776.049.790, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm2.1Vpa,Tg(Chat-cre)GM24Gsat/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr