ENSMUSG00000053310


Mus musculus

Features
Gene ID: ENSMUSG00000053310
  
Biological name :Nrgn
  
Synonyms : Neurogranin NEUG(55-78) / Nrgn / P60761
  
Possible biological names infered from orthology : neurogranin / Q92686
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A4
Gene start: 37544492
Gene end: 37552904
  
Corresponding Affymetrix probe sets: 10592330 (MoGene1.0st)   1423231_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000070113
NCBI entrez gene - 64011     See in Manteia.
MGI - MGI:1927184
RefSeq - NM_022029
RefSeq Peptide - NP_071312
swissprot - P60761
Ensembl - ENSMUSG00000053310
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrgnaENSDARG00000039626Danio rerio
 NRGNENSGALG00000018942Gallus gallus
 NRGNENSG00000154146Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008306 associative learning IEA
 biological_processGO:0021537 telencephalon development IEA
 biological_processGO:0035556 intracellular signal transduction TAS
 biological_processGO:1900273 positive regulation of long-term synaptic potentiation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0012510 trans-Golgi network transport vesicle membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044327 dendritic spine head IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding TAS
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA
 molecular_functionGO:0070300 phosphatidic acid binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Nrg1tm2Cbm/Nrg1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Bmp7tm6(cre)Rob/Bmp7+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nrg1tm2Cbm/Nrg1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nrg1tm2Cbm/Nrg1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Bmp7tm6(cre)Rob/Bmp7+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0002923 increased post-tetanic potential "increase in the size or duration of potentials that persist after tetanic stimulation of central synapses" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Bmp7tm6(cre)Rob/Bmp7+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Bmp7tm6(cre)Rob/Bmp7+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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