ENSMUSG00000053550


Mus musculus

Features
Gene ID: ENSMUSG00000053550
  
Biological name :Shisa7
  
Synonyms : Protein shisa-7 / Q8C3Q5 / Shisa7
  
Possible biological names infered from orthology : A6NL88 / shisa family member 7
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A1
Gene start: 4825552
Gene end: 4844696
  
Corresponding Affymetrix probe sets: 10559681 (MoGene1.0st)   1444046_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112423
Ensembl peptide - ENSMUSP00000064886
Ensembl peptide - ENSMUSP00000112405
NCBI entrez gene - 232813     See in Manteia.
MGI - MGI:3605641
RefSeq - XM_017322147
RefSeq - NM_172737
RefSeq - XM_006539775
RefSeq - XM_011250503
RefSeq - XM_011250504
RefSeq - XM_011250505
RefSeq - XM_011250506
RefSeq - NM_001290291
RefSeq Peptide - NP_001277220
RefSeq Peptide - NP_766325
swissprot - F6T9T6
swissprot - A0A172Q418
swissprot - Q8C3Q5
swissprot - A0A172Q401
Ensembl - ENSMUSG00000053550
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 shisa7aENSDARG00000062462Danio rerio
 shisa7bENSDARG00000063144Danio rerio
 A6NL88ENSG00000187902Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3UH99 / Shisa6 / shisa family member 6 / Q6ZSJ9*ENSMUSG0000005393030
Q9CZN4 / Shisa9 / Protein shisa-9 / B4DS77* / shisa family member 9*ENSMUSG0000002249421
Shisa8 / shisa family member 8 / B8ZZ34*ENSMUSG0000009688321


Protein motifs (from Interpro)
Interpro ID Name
 IPR026910  Shisa family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007613 memory IMP
 biological_processGO:0048172 regulation of short-term neuronal synaptic plasticity IBA
 biological_processGO:1900273 positive regulation of long-term synaptic potentiation IMP
 biological_processGO:1904717 regulation of AMPA glutamate receptor clustering IMP
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032281 AMPA glutamate receptor complex IBA
 cellular_componentGO:0045202 synapse IBA
 cellular_componentGO:0098985 asymmetric, glutamatergic, excitatory synapse IDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Depdc5tm1c(EUCOMM)Hmgu/Depdc5+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6N * CBA

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Depdc5tm1c(EUCOMM)Hmgu/Depdc5+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6N * CBA

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Depdc5tm1c(EUCOMM)Hmgu/Depdc5+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6N * CBA

 MP:0011003 reduced AMPA-mediated synaptic currents "reduction in the measured amplitude, current density or duration of response to stimulation of AMPA receptors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Depdc5tm1c(EUCOMM)Hmgu/Depdc5+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6N * CBA

 MP:0011272 short excitatory postsynaptic current rise time "an decrease in the time required for a signal to change from resting to the peak amplitude value in the evoked excitatory postsynaptic current wave" [MGI:csmith]
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Allelic Composition: Depdc5tm1c(EUCOMM)Hmgu/Depdc5+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6N * CBA

 MP:0011274 short excitatory postsynaptic current decay time 
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Allelic Composition: Depdc5tm1c(EUCOMM)Hmgu/Depdc5+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6N * CBA

 MP:0012319 fast extinction of fear memory "enhanced ability to extinguish aversive memories associated with a traumatic incident" [http://www.mpipsykl.mpg.de/en/research/themes/depression/wotjak_02/]
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Allelic Composition: Depdc5tm1c(EUCOMM)Hmgu/Depdc5+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6N * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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