ENSMUSG00000054362


Mus musculus
tcellLexmincreasedcytotoxiccdcytolysis-positivedecreasedlymphocyteexpansionmoleculemitochondrionactivateddevelopmentdefectiveproliferationinterferon-gammasecretionembryoniclethalitysusceptibilityviralinfectioninducedmorbiditymortalitylungtumorincidencecentral

Features
Gene ID: ENSMUSG00000054362
  
Biological name :Lexm
  
Synonyms : A2AVQ5 / Lexm / Lymphocyte expansion molecule
  
Possible biological names infered from orthology : Q3ZCV2
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C7
Gene start: 106590909
Gene end: 106617241
  
Corresponding Affymetrix probe sets: 10514818 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000102400
Ensembl peptide - ENSMUSP00000139868
Ensembl peptide - ENSMUSP00000118338
Ensembl peptide - ENSMUSP00000066732
NCBI entrez gene - 242602     See in Manteia.
MGI - MGI:2681853
RefSeq - XM_011240528
RefSeq - NM_183182
RefSeq - XM_006503086
RefSeq Peptide - NP_899005
swissprot - A2AVQ5
swissprot - F6X5R4
swissprot - A0A0F6T326
Ensembl - ENSMUSG00000054362
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LEXMENSG00000162398Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR033557  Lymphocyte expansion molecule


Gene Ontology (GO)
cellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellcellorganelleorganelle
TypeGO IDTermEv.Code
 cellular_componentGO:0005739 mitochondrion IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
immune system phenotypehematopoietic system phenotypemortality/agingtumorigenesisimmune system phenotypehematopoietic system phenotypemortality/agingtumorigenesisimmune system phenotypehematopoietic system phenotypemortality/agingtumorigenesisimmune system phenotypehematopoietic system phenotypemortality/agingtumorigenesisimmune system phenotypehematopoietic system phenotypemortality/agingtumorigenesisimmune system phenotypehematopoietic system phenotypemortality/agingtumorigenesisimmune system phenotypehematopoietic system phenotypemortality/agingtumorigenesisimmune system phenotypehematopoietic system phenotypemortality/agingtumorigenesisimmune system phenotypehematopoietic system phenotypemortality/agingtumorigenesisimmune system phenotypehematopoietic system phenotypemortality/agingtumorigenesisimmune system phenotypeimmune system phenotypehematopoietic system phenotypehematopoietic system phenotypemortality/agingmortality/agingtumorigenesistumorigenesis
IDPhenotypeDefinition Genetic BG
 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0002436 abnormal cytotoxic T cell morphology/development "anomalous structure, formation, or numbers of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

Allelic Composition: LexmRetro/Lexm+
Genetic Background: involves: C57BL/6J

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0010267 decreased lung tumor incidence "less than the expected number of neoplams in the lung, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0010847 increased central memory CD8 positive, alpha-beta T cell number "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000907, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0013281 increased cytotoxic T cell cytolysis "increased ability of cytotoxic T cells to induce pathological breakdown of target cells" [MGI:csmith]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

Allelic Composition: LexmRetro/Lexm+
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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