ENSMUSG00000054422


Mus musculus

Features
Gene ID: ENSMUSG00000054422
  
Biological name :Fabp1
  
Synonyms : Fabp1 / Fatty acid-binding protein, liver / P12710
  
Possible biological names infered from orthology : fatty acid binding protein 1 / P07148
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C1
Gene start: 71199827
Gene end: 71205023
  
Corresponding Affymetrix probe sets: 10538965 (MoGene1.0st)   1417556_at (Mouse Genome 430 2.0 Array)   1448764_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064655
NCBI entrez gene - 14080     See in Manteia.
MGI - MGI:95479
RefSeq - NM_017399
RefSeq Peptide - NP_059095
swissprot - P12710
swissprot - Q3V2F7
Ensembl - ENSMUSG00000054422
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fabp1aENSDARG00000019357Danio rerio
 fabp1b.2ENSDARG00000103398Danio rerio
 Q4VBT1ENSDARG00000059227Danio rerio
 FABP1ENSGALG00000015937Gallus gallus
 FABP1ENSG00000163586Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fabp6 / P51162 / Gastrotropin / P51161* / fatty acid binding protein 6*ENSMUSG0000002040542


Protein motifs (from Interpro)
Interpro ID Name
 IPR000463  Cytosolic fatty-acid binding
 IPR012674  Calycin
 IPR031259  Intracellular lipid binding protein
 IPR031276  Liver basic fatty acid-binding protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015909 long-chain fatty acid transport IEA
 biological_processGO:0032000 positive regulation of fatty acid beta-oxidation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0050892 intestinal absorption IEA
 biological_processGO:0051345 positive regulation of hydrolase activity IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005782 peroxisomal matrix IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0045179 apical cortex IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005324 long-chain fatty acid transporter activity IEA
 molecular_functionGO:0005504 fatty acid binding ISO
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016209 antioxidant activity IEA
 molecular_functionGO:0032052 bile acid binding IEA


Pathways (from Reactome)
Pathway description
Triglyceride catabolism
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fabp1tm1Ddsn/Fabp1tm1Ddsn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-1tm1Shk/Nkx2-1tm1Shk
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Fabp1tm1Ddsn/Fabp1tm1Ddsn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fabp1tm1Ddsn/Fabp1tm1Ddsn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002139 abnormal liver/biliary system physiology "altered function of the liver not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-1tm1Shk/Nkx2-1tm1Shk
Genetic Background: involves: 129S4/SvJae

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Fabp1tm1Ddsn/Fabp1tm1Ddsn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Eya4tm1b(KOMP)Wtsi/Eya4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Eya4tm1b(KOMP)Wtsi/Tcp

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fabp1tm1Ddsn/Fabp1tm1Ddsn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Eya4tm1b(KOMP)Wtsi/Eya4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Eya4tm1b(KOMP)Wtsi/Tcp

 MP:0011968 decreased threshold for auditory brainstem response "reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system" [MGI:csmith]
Show

Allelic Composition: Eya4tm1b(KOMP)Wtsi/Eya4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Eya4tm1b(KOMP)Wtsi/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027630 Q8BHJ5 / Tbl1xr1 / F-box-like/WD repeat-containing protein TBL1XR1 / Q9BZK7* / transducin beta like 1 X-linked receptor 1*  / reaction
 ENSMUSG00000022383 Ppara / P23204 / peroxisome proliferator activated receptor alpha / Q07869*  / reaction
 ENSMUSG00000015846 Rxra / P28700 / retinoid X receptor alpha / P19793*  / reaction
 ENSMUSG00000025246 Tbl1x / Q9QXE7 / F-box-like/WD repeat-containing protein TBL1X / TBL1Y* / Q9BQ87* / O60907* / transducin beta like 1 X-linked* / transducin beta like 1 Y-linked*  / reaction






 

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