ENSMUSG00000055027


Mus musculus

Features
Gene ID: ENSMUSG00000055027
  
Biological name :Smyd1
  
Synonyms : P97443 / SET and MYND domain containing 1 / Smyd1
  
Possible biological names infered from orthology : Q8NB12
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C1
Gene start: 71213940
Gene end: 71322233
  
Corresponding Affymetrix probe sets: 10545283 (MoGene1.0st)   1421329_a_at (Mouse Genome 430 2.0 Array)   1427714_at (Mouse Genome 430 2.0 Array)   1441667_s_at (Mouse Genome 430 2.0 Array)   1443726_at (Mouse Genome 430 2.0 Array)   1443727_x_at (Mouse Genome 430 2.0 Array)   1450203_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000073911
Ensembl peptide - ENSMUSP00000134399
Ensembl peptide - ENSMUSP00000109824
Ensembl peptide - ENSMUSP00000109826
Ensembl peptide - ENSMUSP00000133300
Ensembl peptide - ENSMUSP00000133878
NCBI entrez gene - 12180     See in Manteia.
MGI - MGI:104790
RefSeq - NM_001160127
RefSeq - NM_009762
RefSeq Peptide - NP_001153599
RefSeq Peptide - NP_033892
swissprot - Q8BMV4
swissprot - G3UXZ0
swissprot - G3UZ94
swissprot - G5E8R7
swissprot - P97443
swissprot - Q3UQT9
Ensembl - ENSMUSG00000055027
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smyd1aENSDARG00000009280Danio rerio
 smyd1bENSDARG00000091253Danio rerio
 SMYD1ENSGALG00000015935Gallus gallus
 SMYD1ENSG00000115593Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Smyd2 / Q8R5A0 / N-lysine methyltransferase SMYD2 / Q9NRG4* / SET and MYND domain containing 2*ENSMUSG0000002660327
Smyd3 / Q9CWR2 / Histone-lysine N-methyltransferase SMYD3 / Q9H7B4* / SET and MYND domain containing 3*ENSMUSG0000005506727


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR002893  Zinc finger, MYND-type
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006338 chromatin remodeling IPI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0010831 positive regulation of myotube differentiation ISO
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IMP
 biological_processGO:0045663 positive regulation of myoblast differentiation ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0000279 ventricular hypoplasia "reduction in cell number of one or both of the two lower chambers of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0010432 common ventricle "the presence of only one working lower chamber in the heart, usually with a virtual absence of the ventricular septum and usually present in conjunction with double inlet left or right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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