ENSMUSG00000055489


Mus musculus
muscleAno5membraneskeletalanoctaminchloridetransportintracellularendoplasmicreticulumactivatedactivityreducedmitochondrialspermmotilityanoctamin-dimerisationdomainiontransmembraneplasmaintegralcomponentvesiclecalciumchannelproteindimerizationstimuli-sensingchannels

Features
Gene ID: ENSMUSG00000055489
  
Biological name :Ano5
  
Synonyms : Ano5 / Anoctamin-5 / Q75UR0
  
Possible biological names infered from orthology : Q75V66
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B4
Gene start: 51511029
Gene end: 51598709
  
Corresponding Affymetrix probe sets: 10553477 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000046884
Ensembl peptide - ENSMUSP00000146783
Ensembl peptide - ENSMUSP00000147243
NCBI entrez gene - 233246     See in Manteia.
MGI - MGI:3576659
RefSeq - XM_006540825
RefSeq - NM_001271879
RefSeq - NM_177694
RefSeq - XM_006540822
RefSeq - XM_006540823
RefSeq - XM_006540824
RefSeq Peptide - NP_808362
RefSeq Peptide - NP_001258808
swissprot - Q75UR0
Ensembl - ENSMUSG00000055489
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ano5aENSDARG00000015731Danio rerio
 ano5bENSDARG00000036147Danio rerio
 ANO5ENSGALG00000003748Gallus gallus
 ANO5ENSG00000171714Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ano6 / Q6P9J9 / Anoctamin-6 / Q4KMQ2*ENSMUSG0000006421048
Ano4 / Q8C5H1 / Anoctamin-4 / Q32M45*ENSMUSG0000003518941
Ano3 / A2AHL1 / Anoctamin-3 / Q9BYT9*ENSMUSG0000007496841
Ano1 / Q8BHY3 / Anoctamin-1 / Q5XXA6*ENSMUSG0000003107538
Ano2 / Q8CFW1 / Anoctamin-2 / Q9NQ90*ENSMUSG0000003811538
Ano7 / Q14AT5 / Anoctamin-7 / Q6IWH7*ENSMUSG0000003410732
Ano9 / P86044 / Anoctamin-9 / A1A5B4*ENSMUSG0000005466227
Ano8 / Q6PB70 / Anoctamin-8 / Q9HCE9*ENSMUSG0000003486319
Ano10 / Q8BH79 / Anoctamin-10 / Q9NW15*ENSMUSG0000003794918


Protein motifs (from Interpro)
Interpro ID Name
 IPR007632  Anoctamin
 IPR031294  Anoctamin-5
 IPR032394  Anoctamin, dimerisation domain


Gene Ontology (GO)
establishment of localizationestablishment of localizationestablishment of localizationestablishment of localizationestablishment of localizationestablishment of localizationestablishment of localizationestablishment of localizationestablishment of localizationestablishment of localizationestablishment of localizationestablishment of localization
transmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activitytransmembrane transporter activityprotein bindingprotein binding
cellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellcellorganelleorganellemembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0006821 chloride transport ISO
 biological_processGO:0034220 ion transmembrane transport IEA
 cellular_componentGO:0005622 intracellular ISS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031982 vesicle IDA
 molecular_functionGO:0005229 intracellular calcium activated chloride channel activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
muscle phenotypereproductive system phenotypecellular phenotypehomeostasis/metabolism phenotypemuscle phenotypereproductive system phenotypecellular phenotypehomeostasis/metabolism phenotypemuscle phenotypereproductive system phenotypecellular phenotypehomeostasis/metabolism phenotypemuscle phenotypereproductive system phenotypecellular phenotypehomeostasis/metabolism phenotypemuscle phenotypereproductive system phenotypecellular phenotypehomeostasis/metabolism phenotypemuscle phenotypereproductive system phenotypecellular phenotypehomeostasis/metabolism phenotypemuscle phenotypereproductive system phenotypecellular phenotypehomeostasis/metabolism phenotypemuscle phenotypereproductive system phenotypecellular phenotypehomeostasis/metabolism phenotypemuscle phenotypereproductive system phenotypecellular phenotypehomeostasis/metabolism phenotypemuscle phenotypereproductive system phenotypecellular phenotypehomeostasis/metabolism phenotypemuscle phenotypemuscle phenotypereproductive system phenotypereproductive system phenotypecellular phenotypecellular phenotypehomeostasis/metabolism phenotypehomeostasis/metabolism phenotype
IDPhenotypeDefinition Genetic BG
 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gli3tm1Urt/Gli3tm2Blnw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Gli3tm1Urt/Gli3tm2Blnw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gli3tm1Urt/Gli3tm2Blnw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0003082 abnormal gastrocnemius morphology "anomaly in the the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gli3tm1Urt/Gli3tm2Blnw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0003083 abnormal tibialis anterior morphology "anomaly in the the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gli3tm1Urt/Gli3tm2Blnw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0003646 muscle fatigue "increased muscle exhaustion or increased susceptibility to muscle exhaustion" [J:96306]
Show

Allelic Composition: Gli3tm1Urt/Gli3tm2Blnw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gli3tm1Urt/Gli3tm2Blnw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Gli3tm1Urt/Gli3tm2Blnw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0009280 reduced activated sperm motility "loss or reduction of the activated type of sperm mobility, resulting in immotile sperm that are generally unable to reach the uterotubal junction; decreases in activated sperm motility may result in reduced male fertility" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli3tm1Urt/Gli3tm2Blnw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli3tm1Urt/Gli3tm2Blnw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0009414 skeletal muscle fiber necrosis "pathological cell death in the skeletal muscle fibers, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli3tm1Urt/Gli3tm2Blnw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0010090 increased circulating creatine kinase level "an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli3tm1Urt/Gli3tm2Blnw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0013239 impaired skeletal muscle regeneration "reduced ability to repair skeletal muscle after injury or disease" [MGI:csmith]
Show

Allelic Composition: Gli3tm1Urt/Gli3tm2Blnw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0020451 decreased sperm progressive motility "decrease in the ability of sperm to move in a more or less straight line" [MGI:smb]
Show

Allelic Composition: Gli3tm1Urt/Gli3tm2Blnw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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