ENSMUSG00000056313


Mus musculus

Features
Gene ID: ENSMUSG00000056313
  
Biological name :Tcim
  
Synonyms : Q9D915 / Tcim / Transcriptional and immune response regulator
  
Possible biological names infered from orthology : Q9NR00
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A2
Gene start: 24437180
Gene end: 24438984
  
Corresponding Affymetrix probe sets: 10577641 (MoGene1.0st)   1435595_at (Mouse Genome 430 2.0 Array)   1451415_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000058631
NCBI entrez gene - 69068     See in Manteia.
MGI - MGI:1916318
RefSeq - NM_026931
RefSeq Peptide - NP_081207
swissprot - Q9D915
Ensembl - ENSMUSG00000056313
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TCIM (1 of many)ENSDARG00000076858Danio rerio
 tcimaENSDARG00000079497Danio rerio
 TCIMENSGALG00000024083Gallus gallus
 TCIMENSG00000176907Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR020282  Arginine vasopressin-induced protein 1/transcriptional and immune response regulator


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002264 endothelial cell activation involved in immune response IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0010739 positive regulation of protein kinase A signaling IEA
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043620 regulation of DNA-templated transcription in response to stress IEA
 biological_processGO:0045746 negative regulation of Notch signaling pathway IEA
 biological_processGO:1900020 positive regulation of protein kinase C activity IEA
 biological_processGO:1902806 regulation of cell cycle G1/S phase transition IEA
 biological_processGO:1903706 regulation of hemopoiesis IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016607 nuclear speck ISO
 molecular_functionGO:0005112 Notch binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0008247 abnormal mononuclear leukocyte morphology "any structural anomaly of a leukocyte with a single non-segmented nucleus in the mature form" [CL:0000842]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0010067 increased red blood cell distribution width "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0013693 abnormal hemopoiesis "any anomaly in the process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure; the site of hemopoiesis is variable during development, but occurs primarily in bone marrow in mammals" [GO:0030097]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0013696 increased granulocyte monocyte progenitor cell number "increase in the number of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1" [CL:0000557, PMID:16551251]
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Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0013891 increased common myeloid progenitor cell number "increased number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [MGI:llw2]
Show

Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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