ENSMUSG00000056379


Mus musculus

Features
Gene ID: ENSMUSG00000056379
  
Biological name :Taar1
  
Synonyms : Q923Y8 / Taar1 / Trace amine-associated receptor 1
  
Possible biological names infered from orthology : Q96RJ0
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: A4
Gene start: 23920356
Gene end: 23921469
  
Corresponding Affymetrix probe sets: 10362147 (MoGene1.0st)   1422355_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049527
NCBI entrez gene - 111174     See in Manteia.
MGI - MGI:2148258
RefSeq - NM_053205
RefSeq Peptide - NP_444435
swissprot - Q923Y8
Ensembl - ENSMUSG00000056379
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 taar1bENSDARG00000089000Danio rerio
 TAAR1ENSGALG00000013994Gallus gallus
 TAAR1ENSG00000146399Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Taar2 / Q5QD17 / Trace amine-associated receptor 2 / Q9P1P5* / trace amine associated receptor 2 (gene/pseudogene)*ENSMUSG0000005976348
Taar4 / Q5QD15 / Trace amine-associated receptor 4 ENSMUSG0000006970747
Taar9 / Q5QD04 / Trace amine-associated receptor 9 / Q96RI9* / trace amine associated receptor 9 (gene/pseudogene)*ENSMUSG0000003742444
Taar3 / Q5QD16 / Trace amine-associated receptor 3 ENSMUSG0000006970844
Q5QD09 / Taar7e / trace amine-associated receptor 7EENSMUSG0000010068943
Q5QD11 / Taar7b / Trace amine-associated receptor 7b ENSMUSG0000009517142
Q5QD12 / Taar7a / Trace amine-associated receptor 7a ENSMUSG0000009564742
Q5QD08 / Taar7f / Trace amine-associated receptor 7f ENSMUSG0000010095042
Q5QD10 / Taar7d / Trace amine-associated receptor 7d ENSMUSG0000009556941
Taar6 / Q5QD13 / Trace amine-associated receptor 6 / Q96RI8*ENSMUSG0000004511140
Taar8c / Q5QD05 / Trace amine-associated receptor 8c / TAAR8* / Q969N4* / trace amine associated receptor 8*ENSMUSG0000010000440
Taar8b / Q5QD06 / Trace amine-associated receptor 8b / TAAR8* / Q969N4* / trace amine associated receptor 8*ENSMUSG0000010018640
Taar5 / Q5QD14 / Trace amine-associated receptor 5 / O14804*ENSMUSG0000006970639
Taar8a / Q5QD07 / Trace amine-associated receptor 8a / TAAR8* / Q969N4* / trace amine associated receptor 8*ENSMUSG0000009644239
Htr4 / P97288 / 5 hydroxytryptamine (serotonin) receptor 4 / Q13639* / 5-hydroxytryptamine receptor 4*ENSMUSG0000002632234


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR009132  Trace amine associated receptor family
 IPR009133  Trace amine associated receptor 1
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006171 cAMP biosynthetic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane RCA
 molecular_functionGO:0001594 trace-amine receptor activity ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0008227 G-protein coupled amine receptor activity IDA


Pathways (from Reactome)
Pathway description
Amine ligand-binding receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tyrc-26DVT/Tyrc-26DVT
Genetic Background: involves: 101/Rl * C3H/Rl * T-stock

Allelic Composition: Taar1tm1Mmil/Taar1tm1Mmil
Genetic Background: B6.129S2-Taar1tm1Mmil

 MP:0003088 abnormal prepulse inhibition "increase or decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91131]
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Allelic Composition: Tyrc-26DVT/Tyrc-26DVT
Genetic Background: involves: 101/Rl * C3H/Rl * T-stock

 MP:0003964 abnormal noradrenaline level "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tyrc-26DVT/Tyrc-26DVT
Genetic Background: involves: 101/Rl * C3H/Rl * T-stock

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Taar1m1J/Taar1m1J
Genetic Background: DBA/2J

Allelic Composition: Taar1m1J/Taar1+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrc-26DVT/Tyrc-26DVT
Genetic Background: involves: 101/Rl * C3H/Rl * T-stock

Allelic Composition: Taar1tm1Mmil/Taar1tm1Mmil
Genetic Background: B6.129S2-Taar1tm1Mmil

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Taar1tm1Mmil/Taar1tm1Mmil
Genetic Background: B6.129S2-Taar1tm1Mmil

 MP:0008911 induced hyperactivity "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Taar1tm1Mmil/Taar1tm1Mmil
Genetic Background: B6.129S2-Taar1tm1Mmil

 MP:0009749 enhanced behavioral response to addictive substance "increased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrc-26DVT/Tyrc-26DVT
Genetic Background: involves: 101/Rl * C3H/Rl * T-stock

Allelic Composition: Taar1tm1(KOMP)Vlcg/Taar1tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Taar1m1J/Taar1m1J
Genetic Background: DBA/2J

Allelic Composition: Taar1m1J/Taar1m1J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0010069 increased serotonin concentration "increase in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Taar1tm1Mmil/Taar1tm1Mmil
Genetic Background: B6.129S2-Taar1tm1Mmil

 MP:0011016 increased core body temperature "increased degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Taar1tm1Mmil/Taar1tm1Mmil
Genetic Background: B6.129S2-Taar1tm1Mmil

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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