ENSMUSG00000058135


Mus musculus

Features
Gene ID: ENSMUSG00000058135
  
Biological name :Gstm1
  
Synonyms : Glutathione S-transferase Mu 1 / Gstm1 / P10649
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.3
Gene start: 108012255
Gene end: 108017973
  
Corresponding Affymetrix probe sets: 10501229 (MoGene1.0st)   1416416_x_at (Mouse Genome 430 2.0 Array)   1425626_at (Mouse Genome 430 2.0 Array)   1425627_x_at (Mouse Genome 430 2.0 Array)   1448330_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004140
Ensembl peptide - ENSMUSP00000118874
Ensembl peptide - ENSMUSP00000123481
NCBI entrez gene - 14862     See in Manteia.
MGI - MGI:95860
RefSeq - XM_006501017
RefSeq - NM_010358
RefSeq Peptide - NP_034488
swissprot - A2AE89
swissprot - P10649
swissprot - F6WHQ7
Ensembl - ENSMUSG00000058135
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gstm.1ENSDARG00000042533Danio rerio
 gstm.2ENSDARG00000029473Danio rerio
 gstm.3ENSDARG00000088116Danio rerio
 GSTM2ENSGALG00000032922Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gstm3 / P19639 / Glutathione S-transferase Mu 3 ENSMUSG0000000403884
Gstm2 / P15626 / Glutathione S-transferase Mu 2 / GSTM5* / GSTM1* / P09488* / P46439* / glutathione S-transferase mu 1* / glutathione S-transferase mu 5*ENSMUSG0000004056280
Gstm7 / Q80W21 / Glutathione S-transferase Mu 7 / GSTM2* / P28161* / glutathione S-transferase mu 2*ENSMUSG0000000403575
Gstm6 / O35660 / Glutathione S-transferase Mu 6 / GSTM5* / GSTM1* / P09488* / P46439* / glutathione S-transferase mu 5* / glutathione S-transferase mu 1*ENSMUSG0000006876274
Gstm4 / glutathione S-transferase mu 4 / Q03013*ENSMUSG0000002789072
Gstm5 / P48774 / Glutathione S-transferase Mu 5 / GSTM3* / P21266* / glutathione S-transferase mu 3*ENSMUSG0000000403265
Gm6665 / GSTM1* / GSTM5* / P46439* / P09488* / glutathione S-transferase mu 1* / glutathione S-transferase mu 5*ENSMUSG0000009156131
Gstp1 / P19157 / Glutathione S-transferase P 1 / P09211* / glutathione S-transferase pi 1*ENSMUSG0000006080330
Gstp2 / P46425 / Glutathione S-transferase P 2 / GSTP1* / P09211* / glutathione S-transferase pi 1*ENSMUSG0000003815528
Gstp3ENSMUSG0000005821624


Protein motifs (from Interpro)
Interpro ID Name
 IPR003081  Glutathione S-transferase, Mu class
 IPR004045  Glutathione S-transferase, N-terminal
 IPR004046  Glutathione S-transferase, C-terminal
 IPR010987  Glutathione S-transferase, C-terminal-like
 IPR036249  Thioredoxin-like superfamily
 IPR036282  Glutathione S-transferase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006749 glutathione metabolic process ISO
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0035690 cellular response to drug IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0045171 intercellular bridge ISO
 molecular_functionGO:0004364 glutathione transferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Tmed299J/Tmed2Gt(PST809)Mfgc
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Tmed299J/Tmed2Gt(PST809)Mfgc
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6J

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tmed299J/Tmed2Gt(PST809)Mfgc
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6J

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tmed299J/Tmed2Gt(PST809)Mfgc
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Tmed299J/Tmed2Gt(PST809)Mfgc
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6J

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmed299J/Tmed2Gt(PST809)Mfgc
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6J

 MP:0008875 abnormal pharmacokinetics of xenobiotics "any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr2cn/Npr2cn
Genetic Background: involves: AKR/J

 MP:0009745 abnormal behavioral response to xenobiotic "any anomaly in the behavioral response induced by a foreign compound, such as consumption preference, induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmed299J/Tmed2Gt(PST809)Mfgc
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6J

 MP:0010069 increased serotonin concentration "increase in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tmed299J/Tmed2Gt(PST809)Mfgc
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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