ENSMUSG00000058550


Mus musculus

Features
Gene ID: ENSMUSG00000058550
  
Biological name :Dppa4
  
Synonyms : Developmental pluripotency-associated protein 4 / Dppa4 / Q8CCG4
  
Possible biological names infered from orthology : developmental pluripotency associated 4 / Q7L190
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B5
Gene start: 48283735
Gene end: 48294292
  
Corresponding Affymetrix probe sets: 10436050 (MoGene1.0st)   10486954 (MoGene1.0st)   1429597_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000093748
Ensembl peptide - ENSMUSP00000093749
NCBI entrez gene - 73693     See in Manteia.
MGI - MGI:2157525
RefSeq - NM_001018002
RefSeq - NM_028610
RefSeq Peptide - NP_001018002
RefSeq Peptide - NP_082886
swissprot - Q8CCG4
swissprot - E9PUG8
Ensembl - ENSMUSG00000058550
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DPPA4ENSG00000121570Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dppa2 / Q9CWH0 / Developmental pluripotency-associated protein 2 / Q7Z7J5* / developmental pluripotency associated 2*ENSMUSG0000007241923


Protein motifs (from Interpro)
Interpro ID Name
 IPR025891  Developmental pluripotency-associated protein 2/4, C-terminal domain
 IPR025892  Developmental pluripotency-associated protein 2/4, central domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0060484 lung-associated mesenchyme development IMP
 cellular_componentGO:0005634 nucleus IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Ttrtm1Wsb/Ttr+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dppa2tm1.1Yam/Dppa2tm1.1Yam,Dppa4tm1.1Yam/Dppa4tm1.1Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Ttrtm1Wsb/Ttr+
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Dppa2tm1.2Yam/Dppa2tm1.2Yam,Dppa4tm1.1Yam/Dppa4tm1.1Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Dppa2tm1.1Yam/Dppa2tm1.1Yam,Dppa4tm1.2Yam/Dppa4tm1.2Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Dppa2tm1.1Yam/Dppa2tm1.1Yam,Dppa4tm1.1Yam/Dppa4tm1.1Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ttrtm1Wsb/Ttr+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Dppa2tm1.1Yam/Dppa2tm1.1Yam,Dppa4tm1.1Yam/Dppa4tm1.1Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ttrtm1Wsb/Ttr+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Dppa2tm1.1Yam/Dppa2tm1.1Yam,Dppa4tm1.1Yam/Dppa4tm1.1Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dppa2tm1.1Yam/Dppa2tm1.1Yam,Dppa4tm1.1Yam/Dppa4tm1.1Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ttrtm1Wsb/Ttr+
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Dppa2tm1.1Yam/Dppa2tm1.1Yam,Dppa4tm1.2Yam/Dppa4tm1.2Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Dppa2tm1.1Yam/Dppa2tm1.1Yam,Dppa4tm1.1Yam/Dppa4tm1.1Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ttrtm1Wsb/Ttr+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttrtm1Wsb/Ttr+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0004678 split xiphoid process "the appearance of an abnormal division of the posterior tip of the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttrtm1Wsb/Ttr+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0008146 asymmetric rib-sternum attachment "loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttrtm1Wsb/Ttr+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttrtm1Wsb/Ttr+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dppa2tm1.2Yam/Dppa2tm1.2Yam,Dppa4tm1.1Yam/Dppa4tm1.1Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
Show

Allelic Composition: Dppa2tm1.1Yam/Dppa2tm1.1Yam,Dppa4tm1.1Yam/Dppa4tm1.1Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Dppa2tm1.2Yam/Dppa2tm1.2Yam,Dppa4tm1.1Yam/Dppa4tm1.1Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Dppa2tm1.1Yam/Dppa2tm1.1Yam,Dppa4tm1.1Yam/Dppa4tm1.1Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ttrtm1Wsb/Ttr+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Dppa2tm1.1Yam/Dppa2tm1.1Yam,Dppa4tm1.1Yam/Dppa4tm1.1Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Ttrtm1Wsb/Ttr+
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Dppa2tm1.2Yam/Dppa2tm1.2Yam,Dppa4tm1.1Yam/Dppa4tm1.1Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Dppa2tm1.1Yam/Dppa2tm1.1Yam,Dppa4tm1.2Yam/Dppa4tm1.2Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Dppa2tm1.1Yam/Dppa2tm1.1Yam,Dppa4tm1.1Yam/Dppa4tm1.1Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dppa2tm1.1Yam/Dppa2tm1.1Yam,Dppa4tm1.2Yam/Dppa4tm1.2Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Dppa2tm1.2Yam/Dppa2tm1.2Yam,Dppa4tm1.1Yam/Dppa4tm1.1Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Dppa2tm1.1Yam/Dppa2tm1.1Yam,Dppa4tm1.2Yam/Dppa4tm1.2Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dppa2tm1.2Yam/Dppa2tm1.2Yam,Dppa4tm1.1Yam/Dppa4tm1.1Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Dppa2tm1.1Yam/Dppa2tm1.1Yam,Dppa4tm1.1Yam/Dppa4tm1.1Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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