ENSMUSG00000058818


Mus musculus

Features
Gene ID: ENSMUSG00000058818
  
Biological name :Pirb
  
Synonyms : Leukocyte immunoglobulin-like receptor subfamily B member 3 / P97484 / Pirb
  
Possible biological names infered from orthology : A6NI73 / leukocyte immunoglobulin like receptor A4 / leukocyte immunoglobulin like receptor A5 / leukocyte immunoglobulin like receptor A6 / leukocyte immunoglobulin like receptor B3 / leukocyte immunoglobulin like receptor B5 / LILRA4 / LILRA5 / LILRA6 / LILRB3 / LILRB5 / O75022 / O75023 / P59901 / Q6PI73
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A1
Gene start: 3711409
Gene end: 3720391
  
Corresponding Affymetrix probe sets: 10559446 (MoGene1.0st)   10559454 (MoGene1.0st)   10559467 (MoGene1.0st)   1420464_s_at (Mouse Genome 430 2.0 Array)   1424302_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077546
NCBI entrez gene - 18733     See in Manteia.
MGI - MGI:894311
RefSeq - XM_006539635
RefSeq - NM_011095
RefSeq - XM_006539633
RefSeq - XM_006539634
RefSeq Peptide - NP_035225
swissprot - P97484
Ensembl - ENSMUSG00000058818
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A6NI73ENSG00000187116Homo sapiens
 LILRA4ENSG00000239961Homo sapiens
 LILRA6ENSG00000244482Homo sapiens
 LILRB3ENSG00000204577Homo sapiens
 LILRB5ENSG00000105609Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm14548 / Mus musculus paired-Ig-like receptor A11 (Pira11), mRNA. / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte immunoglob...ENSMUSG0000007441773
Pira2 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte immunoglobulin like receptor A5* / leukocyte immunoglobulin like recept...ENSMUSG0000008994273
Gm15922 / predicted gene 15922 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte immunoglobulin like receptor A5* / leukocyte i...ENSMUSG0000008166572
Gm15448 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte immunoglobulin like receptor A4* / leukocyte immunoglobulin like rece...ENSMUSG0000007441971
Lilra6 / leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRB3* / leukocyte...ENSMUSG0000003042770
Q64281 / Lilrb4a / Leukocyte immunoglobulin-like receptor subfamily B member 4 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocy...ENSMUSG0000006259317
Q64281 / Lilrb4 / Leukocyte immunoglobulin-like receptor subfamily B member 4 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyt...ENSMUSG0000011214817
Lilr4b / Q61450 / Mast cell surface glycoprotein Gp49A / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA5* / LILRA6* / LILRB3* / leukocyte immunoglobulin like r...ENSMUSG0000011202314
Lilra5 / Q6PI73* / LILRB5* / O75022* / O75023* / P59901* / A6NI73* / LILRA4* / LILRA6* / LILRB3* / leukocyte immunoglobulin like receptor A5* / leukocyte immunoglobulin like receptor A6* / ...ENSMUSG0000007087313
Kir3dl1 / Q99706* / P43626* / P43628* / P43629* / P43630* / KIR3DL2* / KIR2DL1* / KIR2DL3* / KIR2DL4* / KIR2DS4* / KIR3DL3* / killer cell immunoglobulin like receptor, two Ig domains and lo...ENSMUSG0000003142412
Kir3dl2 / Q99706* / P43626* / P43628* / P43629* / P43630* / KIR2DL1* / KIR3DL3* / KIR2DL3* / KIR2DL4* / KIR2DS4* / KIR3DL1* / killer cell immunoglobulin like receptor, two Ig domains and lo...ENSMUSG0000005743912
Ncr1 / natural cytotoxicity triggering receptor 1 / O76036*ENSMUSG0000006252412
Gp6 / P0C191 / Platelet glycoprotein VI / Q9HCN6* / glycoprotein VI platelet*ENSMUSG0000007881011


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001782 B cell homeostasis IMP
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007611 learning or memory IGI
 biological_processGO:0019221 cytokine-mediated signaling pathway IMP
 biological_processGO:0019724 B cell mediated immunity IMP
 biological_processGO:0035307 positive regulation of protein dephosphorylation IGI
 biological_processGO:0043011 myeloid dendritic cell differentiation IMP
 biological_processGO:0051248 negative regulation of protein metabolic process IGI
 biological_processGO:1900271 regulation of long-term synaptic potentiation IGI
 biological_processGO:1900454 positive regulation of long term synaptic depression IGI
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0106003 amyloid-beta complex IDA
 molecular_functionGO:0001540 amyloid-beta binding IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0044877 protein-containing complex binding IPI


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0000805 abnormal visual cortex morphology "malformation or absence of the area of the occipital cortex concerned with vision" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Npr1tm1(Npr1)Unc/Npr1tm1(Npr1)Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0008115 abnormal dendritic cell differentiation "atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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