ENSMUSG00000058897


Mus musculus

Features
Gene ID: ENSMUSG00000058897
  
Biological name :Col25a1
  
Synonyms : Col25a1 / Collagen alpha-1(XXV) chain Collagen-like Alzheimer amyloid plaque component / Q99MQ5
  
Possible biological names infered from orthology : collagen type XXV alpha 1 chain / Q9BXS0
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G3
Gene start: 130131501
Gene end: 130599877
  
Corresponding Affymetrix probe sets: 10496036 (MoGene1.0st)   1421427_at (Mouse Genome 430 2.0 Array)   1432325_at (Mouse Genome 430 2.0 Array)   1438540_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079210
Ensembl peptide - ENSMUSP00000101960
Ensembl peptide - ENSMUSP00000138875
NCBI entrez gene - 77018     See in Manteia.
MGI - MGI:1924268
RefSeq - XM_017319806
RefSeq - NM_001244952
RefSeq - NM_029838
RefSeq - NM_198711
RefSeq - XM_006502282
RefSeq - XM_006502283
RefSeq - XM_006502284
RefSeq - XM_006502285
RefSeq - XM_006502286
RefSeq - XM_017319804
RefSeq - XM_006502264
RefSeq - XM_006502265
RefSeq - XM_006502266
RefSeq - XM_006502267
RefSeq - XM_006502268
RefSeq - XM_006502269
RefSeq - XM_006502270
RefSeq - XM_006502271
RefSeq - XM_006502272
RefSeq - XM_006502273
RefSeq - XM_006502274
RefSeq - XM_006502275
RefSeq - XM_006502276
RefSeq - XM_006502277
RefSeq - XM_006502278
RefSeq - XM_006502279
RefSeq - XM_006502280
RefSeq - XM_006502281
RefSeq Peptide - NP_001231881
RefSeq Peptide - NP_084114
RefSeq Peptide - NP_942004
swissprot - Q99MQ5
swissprot - V9GWX5
swissprot - E9Q5L6
Ensembl - ENSMUSG00000058897
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 COL25A1ENSGALG00000039411Gallus gallus
 Q9BXS0ENSG00000188517Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8K4G2 / Col23a1 / Collagen alpha-1(XXIII) chain / Q86Y22* / collagen type XXIII alpha 1 chain*ENSMUSG0000006356444
Q9R1N9 / Col13a1 / Collagen alpha-1(XIII) chain / Q5TAT6* / collagen type XIII alpha 1 chain*ENSMUSG0000005880641
Col9a3 / collagen, type IX, alpha 3 / Q14050* / collagen type IX alpha 3 chain*ENSMUSG0000002757034
Col9a1 / collagen type IX alpha 1 chain / P20849*ENSMUSG0000002614732
Col9a2 / collagen type IX alpha 2 chain / Q14055*ENSMUSG0000002862632


Protein motifs (from Interpro)
Interpro ID Name
 IPR008160  Collagen triple helix repeat
 IPR016133  Insect cysteine-rich antifreeze protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0060385 axonogenesis involved in innervation IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0008201 heparin binding ISS


Pathways (from Reactome)
Pathway description
Collagen degradation
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Col25a1tm1.1Tiwa/Col25a1tm1.1Tiwa,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: B6.Cg-Col25a1tm1.1Tiwa Tg(Hlxb9-GFP)1Tmj

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Col25a1tm1.1Tiwa/Col25a1tm1.1Tiwa,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: B6.Cg-Col25a1tm1.1Tiwa Tg(Hlxb9-GFP)1Tmj

 MP:0001078 abnormal phrenic nerve "malformed or misprojection of motor and sensory neuron axons to the diaphragm and other tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Col25a1tm1.1Tiwa/Col25a1tm1.1Tiwa,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: B6.Cg-Col25a1tm1.1Tiwa Tg(Hlxb9-GFP)1Tmj

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Col25a1tm1.1Tiwa/Col25a1+
Genetic Background: B6.Cg-Col25a1tm1.1Tiwa Baxtm1Sjk

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Col25a1tm1.1Tiwa/Col25a1tm1.1Tiwa,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: B6.Cg-Col25a1tm1.1Tiwa Tg(Hlxb9-GFP)1Tmj

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0012055 abnormal phrenic nerve innervation pattern to diaphragm "any changes in the placement, morphology or number of the portion of phrenic nerve fibers providing motor supply to the diaphragm" [MGI:csmith]
Show

Allelic Composition: Col25a1tm1.1Tiwa/Col25a1tm1.1Tiwa,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: B6.Cg-Col25a1tm1.1Tiwa Tg(Hlxb9-GFP)1Tmj

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Col25a1tm1.1Tiwa/Col25a1tm1.1Tiwa
Genetic Background: B6.Cg-Col25a1tm1.1Tiwa Baxtm1Sjk

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr