ENSMUSG00000059077


Mus musculus

Features
Gene ID: ENSMUSG00000059077
  
Biological name :Pth
  
Synonyms : parathyroid hormone / Pth
  
Possible biological names infered from orthology : P01270
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F1
Gene start: 113385580
Gene end: 113388570
  
Corresponding Affymetrix probe sets: 10567034 (MoGene1.0st)   1419345_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078723
NCBI entrez gene - 19226     See in Manteia.
MGI - MGI:97799
RefSeq - NM_020623
RefSeq Peptide - NP_065648
swissprot - Q9Z0L6
Ensembl - ENSMUSG00000059077
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PTHENSGALG00000042878Gallus gallus
 PTHENSG00000152266Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001415  Parathyroid hormone/parathyroid hormone-related protein
 IPR003625  Parathyroid hormone


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001501 skeletal system development IBA
 biological_processGO:0006874 cellular calcium ion homeostasis ISO
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007202 activation of phospholipase C activity IEA
 biological_processGO:0007266 Rho protein signal transduction IEA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0009967 positive regulation of signal transduction IMP
 biological_processGO:0010288 response to lead ion IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0030819 obsolete positive regulation of cAMP biosynthetic process IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032331 negative regulation of chondrocyte differentiation IEA
 biological_processGO:0033280 response to vitamin D IEA
 biological_processGO:0034645 cellular macromolecule biosynthetic process IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045453 bone resorption IBA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045725 positive regulation of glycogen biosynthetic process IEA
 biological_processGO:0045778 positive regulation of ossification IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046326 positive regulation of glucose import IEA
 biological_processGO:0046686 response to cadmium ion IEA
 biological_processGO:0048873 homeostasis of number of cells within a tissue IGI
 biological_processGO:0060732 positive regulation of inositol phosphate biosynthetic process IEA
 biological_processGO:0071107 response to parathyroid hormone IEA
 biological_processGO:0071774 response to fibroblast growth factor IEA
 biological_processGO:0071864 positive regulation of cell proliferation in bone marrow IGI
 biological_processGO:0071866 negative regulation of apoptotic process in bone marrow IGI
 biological_processGO:0090290 positive regulation of osteoclast proliferation IGI
 biological_processGO:1900158 negative regulation of bone mineralization involved in bone maturation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0005179 hormone activity ISO
 molecular_functionGO:0031856 parathyroid hormone receptor binding IEA
 molecular_functionGO:0031857 type 1 parathyroid hormone receptor binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0048018 receptor ligand activity IEA
 molecular_functionGO:0051428 peptide hormone receptor binding IEA


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Pthtm1Dgo/Pthtm1Dgo,Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Pthtm1Dgo/Pthtm1Dgo,Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Pthtm1Dgo/Pthtm1Dgo,Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Pthtm1Dgo/Pthtm1Dgo,Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: Pthtm1Dgo/Pthtm1Dgo,Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pthtm1Dgo/Pthtm1Dgo,Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Pthtm1Dgo/Pthtm1Dgo,Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003112 enlarged parathyroid gland 
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Pthtm1Dgo/Pthtm1Dgo,Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Pthtm1Dgo/Pthtm1Dgo,Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
Show

Allelic Composition: Pthtm1Dgo/Pthtm1Dgo,Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Pthtm1Dgo/Pthtm1Dgo,Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004148 increased cortical bone thickness "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Pthtm1Dgo/Pthtm1Dgo,Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004634 short metacarpal bones "reduced length of the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004635 short metatarsal bones "reduced length of the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004670 small vertebral body "decreased size of the main cylindrical portion of the vertebra ventral to the vertebral canal" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Pthtm1Dgo/Pthtm1Dgo,Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Pthtm1Dgo/Pthtm1Dgo,Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Pthtm1Dgo/Pthtm1Dgo,Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Pthtm1Dgo/Pthtm1Dgo,Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pthtm1Dgo/Pthtm1Dgo,Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0009250 abnormal appendicular skeleton morphology "any structural anomaly of the bones of the limbs, shoulder and pelvic girdles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Pthtm1Dgo/Pthtm1Dgo,Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Pthtm1Dgo/Pthtm1Dgo,Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0014103 increased chondrocyte apoptosis "increased number of chondrocytes undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Pthtm1Dgo/Pthtm1Dgo,Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0030441 increased osteoblast apoptosis "increase in the number of osteoblasts undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Pthtm1Dgo/Pthtm1Dgo,Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0030479 increased osteocyte apoptosis "increase in the number of osteocytes undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Pthtm1Dgo/Pthtm1Dgo,Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032492 Pth1r / P41593 / Parathyroid hormone/parathyroid hormone-related peptide receptor / Q03431* / parathyroid hormone 1 receptor*  / complex / reaction
 ENSMUSG00000025946 Pth2r / Q91V95 / Parathyroid hormone 2 receptor / P49190*  / complex / reaction






 

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