ENSMUSG00000059336


Mus musculus

Features
Gene ID: ENSMUSG00000059336
  
Biological name :Slc14a1
  
Synonyms : Q8VHL0 / Slc14a1 / Urea transporter 1
  
Possible biological names infered from orthology : Q13336 / solute carrier family 14 member 1 (Kidd blood group)
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: E3
Gene start: 78100091
Gene end: 78142119
  
Corresponding Affymetrix probe sets: 10459866 (MoGene1.0st)   1428114_at (Mouse Genome 430 2.0 Array)   1448640_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000089421
Ensembl peptide - ENSMUSP00000125114
Ensembl peptide - ENSMUSP00000125367
NCBI entrez gene - 108052     See in Manteia.
MGI - MGI:1351654
RefSeq - NM_001171011
RefSeq - NM_001171010
RefSeq - NM_028122
RefSeq Peptide - NP_001164481
RefSeq Peptide - NP_001164482
RefSeq Peptide - NP_082398
swissprot - Q8VHL0
Ensembl - ENSMUSG00000059336
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-183c6.7ENSDARG00000102029Danio rerio
 slc14a2ENSDARG00000051914Danio rerio
 SLC14A1ENSGALG00000035595Gallus gallus
 Q13336ENSG00000141469Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc14a2 / urea transporter 2 isoform b / Q15849* / solute carrier family 14 member 2*ENSMUSG0000002455256


Protein motifs (from Interpro)
Interpro ID Name
 IPR004937  Urea transporter
 IPR029020  Ammonium/urea transporter


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006833 water transport IGI
 biological_processGO:0015840 urea transport IMP
 biological_processGO:0071918 urea transmembrane transport ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0005372 water transmembrane transporter activity IDA
 molecular_functionGO:0015204 urea transmembrane transporter activity IMP
 molecular_functionGO:0015265 urea channel activity ISO


Pathways (from Reactome)
Pathway description
Transport of bile salts and organic acids, metal ions and amine compounds


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000226 abnormal mean corpuscular volume "deviation from the norm for the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Slc14a1tm1Ask/Slc14a1tm1Ask,Slc14a2tm1Bxy/Slc14a2tm1Bxy
Genetic Background: involves: C57BL/6J

 MP:0002593 high mean erythrocyte count "greater than average numbers of red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Slc14a1tm1Ask/Slc14a1tm1Ask
Genetic Background: involves: C57BL/6J

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Slc14a1tm1Ask/Slc14a1tm1Ask
Genetic Background: involves: C57BL/6J

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Slc14a1tm1Ask/Slc14a1tm1Ask,Slc14a2tm1Bxy/Slc14a2tm1Bxy
Genetic Background: involves: C57BL/6J

 MP:0003378 early sexual maturation "pubertal changes occur at an earlier than normal age" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv * C57BL/6

 MP:0003830 abnormal testis development "abnormal morphogenesis of the male reproductive gland containing the germ cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100020]
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Allelic Composition: Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv * C57BL/6

 MP:0004109 abnormal Sertoli cell development "anomalous differentiation of cells that support germ cell differentiation in males" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv * C57BL/6

 MP:0004851 increased testis weight "greater average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv * C57BL/6

 MP:0004884 abnormal testicular physiology "anomaly or loss either the production of male germ cells or the endocrine cells for the production testosterone" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv * C57BL/6

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv * C57BL/6

 MP:0005556 abnormal kidney clearance "altered ability of the kidneys to remove substances from the plasma for excretion in a specific period of time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Slc14a1tm1Ask/Slc14a1tm1Ask,Slc14a2tm1Bxy/Slc14a2tm1Bxy
Genetic Background: involves: C57BL/6J

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Slc14a1tm1Ask/Slc14a1tm1Ask,Slc14a2tm1Bxy/Slc14a2tm1Bxy
Genetic Background: involves: C57BL/6J

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Slc14a1tm1Ask/Slc14a1tm1Ask
Genetic Background: involves: C57BL/6J * CD-1

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Slc14a1tm1Ask/Slc14a1tm1Ask
Genetic Background: involves: C57BL/6J

 MP:0011467 decreased urine urea nitrogen level "abnormally low amounts of nitrogen in the form of urea in the urine" [MGI:csmith]
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Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0011471 decreased urine creatinine level "a reduced amount of creatinine in the urine compared to the normal state" [MGI:csmith]
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Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Slc14a1tm1Ask/Slc14a1tm1Ask,Slc14a2tm1Bxy/Slc14a2tm1Bxy
Genetic Background: involves: C57BL/6J

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Slc14a1tm1Ask/Slc14a1tm1Ask,Slc14a2tm1Bxy/Slc14a2tm1Bxy
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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