ENSMUSG00000059401


Mus musculus
transcriptionMamld1domainnotchregulatesdecreasedproteindna-templatedregulationbodyintracellularcountwdyvtnrepeat-like-containingsuperfamilymastermind-likedomain-containingrnapolymeraseiimalegonaddevelopmentcellularcomponentnucleusnucleoplasmgolgiapparatuscentrosome

Features
Gene ID: ENSMUSG00000059401
  
Biological name :Mamld1
  
Synonyms : Mamld1 / Mastermind-like domain-containing protein 1 / P0C6A2
  
Possible biological names infered from orthology : mastermind like domain containing 1 / Q13495
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A7.3
Gene start: 71050256
Gene end: 71156056
  
Corresponding Affymetrix probe sets: 10599962 (MoGene1.0st)   1458221_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000080737
Ensembl peptide - ENSMUSP00000110276
NCBI entrez gene - 333639     See in Manteia.
MGI - MGI:3045303
RefSeq - XM_017318531
RefSeq - NM_001081354
RefSeq - NM_001256048
RefSeq - XM_011247622
RefSeq Peptide - NP_001242977
RefSeq Peptide - NP_001074823
swissprot - P0C6A2
swissprot - D3Z768
Ensembl - ENSMUSG00000059401
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAMLD1ENSGALG00000009098Gallus gallus
 MAMLD1ENSG00000013619Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR026131  Mastermind-like domain-containing protein 1


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentnitrogen compound metabnitrogen compound metabolic processbiosynthetic processbiosynthetic processcellular metabolic proccellular metabolic processprimary metabolic proceprimary metabolic processorganic substance metaborganic substance metabolic processanatomical structure deanatomical structure development
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumen
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0008584 male gonad development IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Notch-HLH transcription pathway
RUNX3 regulates NOTCH signaling


Phenotype (from MGI, Zfin or HPO)
immune system phenotypehematopoietic system phenotypehomeostasis/metabolism phenotypegrowth/size phenotypebehavior/neurological phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypehomeostasis/metabolism phenotypegrowth/size phenotypebehavior/neurological phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypehomeostasis/metabolism phenotypegrowth/size phenotypebehavior/neurological phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypehomeostasis/metabolism phenotypegrowth/size phenotypebehavior/neurological phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypehomeostasis/metabolism phenotypegrowth/size phenotypebehavior/neurological phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypehomeostasis/metabolism phenotypegrowth/size phenotypebehavior/neurological phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypehomeostasis/metabolism phenotypegrowth/size phenotypebehavior/neurological phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypehomeostasis/metabolism phenotypegrowth/size phenotypebehavior/neurological phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypehomeostasis/metabolism phenotypegrowth/size phenotypebehavior/neurological phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypehomeostasis/metabolism phenotypegrowth/size phenotypebehavior/neurological phenotypeskeleton phenotypeimmune system phenotypeimmune system phenotypehematopoietic system phhematopoietic system phenotypehomeostasis/metabolism homeostasis/metabolism phenotypegrowth/size phenotypegrowth/size phenotypebehavior/neurological pbehavior/neurological phenotypeskeleton phenotypeskeleton phenotype
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0002965 hyperalbuminemia "blood albumin concentration above the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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