ENSMUSG00000060073


Mus musculus

Features
Gene ID: ENSMUSG00000060073
  
Biological name :Psma3
  
Synonyms : O70435 / proteasome (prosome, macropain) subunit, alpha type 3 / Psma3
  
Possible biological names infered from orthology : P25788 / proteasome subunit alpha 3
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C2
Gene start: 70974621
Gene end: 70996347
  
Corresponding Affymetrix probe sets: 10396193 (MoGene1.0st)   10419711 (MoGene1.0st)   10543783 (MoGene1.0st)   1441707_at (Mouse Genome 430 2.0 Array)   1448442_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125490
Ensembl peptide - ENSMUSP00000124894
Ensembl peptide - ENSMUSP00000125548
Ensembl peptide - ENSMUSP00000125739
Ensembl peptide - ENSMUSP00000071624
Ensembl peptide - ENSMUSP00000124082
NCBI entrez gene - 19167     See in Manteia.
MGI - MGI:104883
RefSeq - XM_017314996
RefSeq - NM_001310595
RefSeq - NM_001310596
RefSeq - NM_011184
RefSeq Peptide - NP_001297524
RefSeq Peptide - NP_001297525
RefSeq Peptide - NP_035314
swissprot - E0CX62
swissprot - E0CZ34
swissprot - F7BWF9
swissprot - E0CYL6
swissprot - F8WH02
swissprot - O70435
swissprot - Q58EV4
Ensembl - ENSMUSG00000060073
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psma3ENSDARG00000086618Danio rerio
 PSMA3ENSGALG00000012039Gallus gallus
 PSMA3ENSG00000100567Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000426  Proteasome alpha-subunit, N-terminal domain
 IPR001353  Proteasome, subunit alpha/beta
 IPR023332  Proteasome alpha-type subunit
 IPR029055  Nucleophile aminohydrolases, N-terminal
 IPR035150  Proteasome subunit alpha 3
 IPR037555  Proteasome subunit alpha type 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IEA
 biological_processGO:0052548 regulation of endopeptidase activity IEA
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005839 proteasome core complex IEA
 cellular_componentGO:0019773 proteasome core complex, alpha-subunit complex IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004298 threonine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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