ENSMUSG00000060675


Mus musculus

Features
Gene ID: ENSMUSG00000060675
  
Biological name :Pla2g16
  
Synonyms : HRAS-like suppressor 3 / Pla2g16 / Q8R3U1
  
Possible biological names infered from orthology : P53816 / phospholipase A2 group XVI
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 7557459
Gene end: 7588545
  
Corresponding Affymetrix probe sets: 10461093 (MoGene1.0st)   1445597_s_at (Mouse Genome 430 2.0 Array)   1451611_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119403
Ensembl peptide - ENSMUSP00000123524
Ensembl peptide - ENSMUSP00000025925
Ensembl peptide - ENSMUSP00000115151
NCBI entrez gene - 225845     See in Manteia.
MGI - MGI:2179715
RefSeq - NM_139269
RefSeq - XM_006526921
RefSeq Peptide - NP_644675
swissprot - D3YYG1
swissprot - Q8R3U1
Ensembl - ENSMUSG00000060675
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P53816ENSG00000176485Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9CPX5 / Hrasls5 / Ca(2+)-independent N-acyltransferase / Q96KN8* / HRAS like suppressor family member 5*ENSMUSG0000002497347
Hrasls / Mus musculus HRAS-like suppressor (Hrasls), transcript variant 2, mRNA. / HRAS like suppressor*ENSMUSG0000002252544


Protein motifs (from Interpro)
Interpro ID Name
 IPR007053  LRAT-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006641 triglyceride metabolic process IMP
 biological_processGO:0006644 phospholipid metabolic process ISO
 biological_processGO:0007031 peroxisome organization IMP
 biological_processGO:0008654 phospholipid biosynthetic process IDA
 biological_processGO:0016042 lipid catabolic process IMP
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0046485 ether lipid metabolic process IMP
 biological_processGO:1904177 regulation of adipose tissue development IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005778 peroxisomal membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004623 phospholipase A2 activity ISO
 molecular_functionGO:0008970 phosphatidylcholine 1-acylhydrolase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0052739 phosphatidylserine 1-acylhydrolase activity IEA
 molecular_functionGO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity IEA
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0003926 impaired cellular glucose import "reduced ability of a cell to take in glucose from the environment" [RGD:Rat Genome Database submission]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0005438 abnormal glycogen homeostasis "abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0008034 enhanced lipolysis "increase in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0009293 decreased inguinal fat pad weight 
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0009303 decreased renal fat pad weight 
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0010182 decreased susceptibility to weight gain "smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0012634 decreased phospholipase A2 level 
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0013245 abnormal lipid metabolism "any anomaly in the chemical reactions and pathways involving a lipid, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0014171 increased fatty acid oxidation "increased rate or incidence of the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen" [GO:0019395]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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