ENSMUSG00000061175


Mus musculus

Features
Gene ID: ENSMUSG00000061175
  
Biological name :Fnip2
  
Synonyms : Fnip2 / Folliculin-interacting protein 2 / Q80TD3
  
Possible biological names infered from orthology : Q9P278
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: E3
Gene start: 79455974
Gene end: 79567796
  
Corresponding Affymetrix probe sets: 10498827 (MoGene1.0st)   1439189_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075497
Ensembl peptide - ENSMUSP00000115275
NCBI entrez gene - 329679     See in Manteia.
MGI - MGI:2683054
RefSeq - XM_017319622
RefSeq - NM_001162999
RefSeq - XM_006501594
RefSeq - XM_017319620
RefSeq - XM_017319621
RefSeq Peptide - NP_001156471
swissprot - Q80TD3
swissprot - D3YUC5
Ensembl - ENSMUSG00000061175
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-42i9.8ENSDARG00000077648Danio rerio
 FNIP2ENSGALG00000020251Gallus gallus
 FNIP2ENSG00000052795Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fnip1 / Q68FD7 / Folliculin-interacting protein 1 / Q8TF40*ENSMUSG0000003599250


Protein motifs (from Interpro)
Interpro ID Name
 IPR026156  Folliculin-interacting protein family
 IPR028084  Folliculin-interacting protein, N-terminal domain
 IPR028085  Folliculin-interacting protein, middle domain
 IPR028086  Folliculin-interacting protein, C-terminal domain
 IPR037545  Tripartite DENN domain, FNIP1/2-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:0031334 positive regulation of protein complex assembly IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0042030 ATPase inhibitor activity IEA
 molecular_functionGO:0051087 chaperone binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sema3ftm1.2Ddg/Sema3ftm1.2Ddg,Sema3gtm1(KOMP)Vlcg/Sema3gtm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Fnip1tm1.1Baba/Fnip1tm1.1Baba,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

Allelic Composition: Flcntm1Baba/Flcntm1Baba,Fnip1tm1.1Baba/Fnip1tm1.1Baba,Fnip2tm1.1Lss/Fnip2tm1.1Lss,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * ICR

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Fnip1tm1.1Baba/Fnip1tm1.1Baba,Fnip2tm1.1Lss/Fnip2tm1.1Lss,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * ICR

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fnip1tm1.1Baba/Fnip1tm1.1Baba,Fnip2tm1.1Lss/Fnip2tm1.1Lss,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * ICR

Allelic Composition: Flcntm1Baba/Flcntm1Baba,Fnip1tm1.1Baba/Fnip1tm1.1Baba,Fnip2tm1.1Lss/Fnip2tm1.1Lss,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * ICR

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0010294 increased kidney tumor incidence "greater than the expected number of tumors originating in the kidney in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flcntm1Baba/Flcntm1Baba,Fnip1tm1.1Baba/Fnip1tm1.1Baba,Fnip2tm1.1Lss/Fnip2tm1.1Lss,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * ICR

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Fnip1tm1.1Baba/Fnip1tm1.1Baba,Fnip2tm1.1Lss/Fnip2tm1.1Lss,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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