ENSMUSG00000061298


Mus musculus

Features
Gene ID: ENSMUSG00000061298
  
Biological name :Agbl4
  
Synonyms : Agbl4 / Cytosolic carboxypeptidase 6 / Q09LZ8
  
Possible biological names infered from orthology : ATP/GTP binding protein like 4 / Q5VU57
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C7
Gene start: 110397661
Gene end: 111664324
  
Corresponding Affymetrix probe sets: 10507015 (MoGene1.0st)   1432512_at (Mouse Genome 430 2.0 Array)   1438158_at (Mouse Genome 430 2.0 Array)   1438308_at (Mouse Genome 430 2.0 Array)   1453932_at (Mouse Genome 430 2.0 Array)   1454259_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102199
Ensembl peptide - ENSMUSP00000102197
Ensembl peptide - ENSMUSP00000102201
Ensembl peptide - ENSMUSP00000118551
Ensembl peptide - ENSMUSP00000102202
Ensembl peptide - ENSMUSP00000079568
Ensembl peptide - ENSMUSP00000095533
NCBI entrez gene - 78933     See in Manteia.
MGI - MGI:1918244
RefSeq - XM_011240655
RefSeq - NM_001048189
RefSeq - NM_001284190
RefSeq - NM_030231
RefSeq - XM_011240652
RefSeq - XM_011240653
RefSeq - XM_011240654
RefSeq Peptide - NP_001271119
RefSeq Peptide - NP_084507
RefSeq Peptide - NP_001041654
swissprot - F6VQN0
swissprot - A2A9S6
swissprot - A2A9S5
swissprot - Q09LZ8
swissprot - E4W7Y4
swissprot - A2A9S7
Ensembl - ENSMUSG00000061298
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 agbl4ENSDARG00000110838Danio rerio
 agbl4ENSDARG00000068050Danio rerio
 AGBL4ENSGALG00000036909Gallus gallus
 AGBL4ENSG00000186094Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Agbl5 / Q09M02 / Cytosolic carboxypeptidase-like protein 5 / Q8NDL9* / ATP/GTP binding protein like 5*ENSMUSG0000002916531
Agbl2 / Q8CDK2 / Mus musculus ATP/GTP binding protein-like 2 (Agbl2), transcript variant 2, mRNA. / Q5U5Z8* / ATP/GTP binding protein like 2*ENSMUSG0000004081228
Q641K1 / Agtpbp1 / Cytosolic carboxypeptidase 1 / Q9UPW5* / ATP/GTP binding protein 1*ENSMUSG0000002155727
Agbl1 / Q09M05 / Cytosolic carboxypeptidase 4 / Q96MI9* / ATP/GTP binding protein like 1*ENSMUSG0000002575427
Agbl3 / Q8CDP0 / Cytosolic carboxypeptidase 3 / Q8NEM8* / ATP/GTP binding protein like 3*ENSMUSG0000003883627


Protein motifs (from Interpro)
Interpro ID Name
 IPR000834  Peptidase M14, carboxypeptidase A


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0035608 protein deglutamylation IMP
 biological_processGO:0035609 C-terminal protein deglutamylation IDA
 biological_processGO:0035610 protein side chain deglutamylation TAS
 biological_processGO:0051607 defense response to virus IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005814 centriole ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0036064 ciliary basal body ISO
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004180 carboxypeptidase activity IEA
 molecular_functionGO:0004181 metallocarboxypeptidase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0015631 tubulin binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Braftm1Mmcm/Braf+,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Braftm1Mmcm/Braf+,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Braftm1Mmcm/Braf+,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Braftm1Mmcm/Braf+,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

 MP:0003405 abnormal platelet shape 
Show

Allelic Composition: Braftm1Mmcm/Braf+,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

 MP:0004720 abnormal platelet morphology "any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Braftm1Mmcm/Braf+,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Braftm1Mmcm/Braf+,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Braftm1Mmcm/Braf+,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Braftm1Mmcm/Braf+,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Braftm1Mmcm/Braf+,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
Show

Allelic Composition: Braftm1Mmcm/Braf+,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: Braftm1Mmcm/Braf+,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

 MP:0009676 abnormal hemostasis "any anomaly in the spontaneous arrest of bleeding from vessels carrying blood under pressure or the arrest of circulation to an organ or part" [MESH:G09.188.124.560, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Braftm1Mmcm/Braf+,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Braftm1Mmcm/Braf+,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

 MP:0014060 abnormal platelet alpha-granule morphology "any structural anomaly of the most abundant secretory organelle found in blood platelets, and which store adhesive molecules such as von Willebrand factor and fibrinogen, growth factors and inflammatory and angiogenic mediators, which play crucial roles in inflammatory responses and tumor genesis" [PMID:26391322]
Show

Allelic Composition: Braftm1Mmcm/Braf+,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

 MP:0020431 decreased platelet alpha-granule number "decreased number of platelet alpha-granules" []
Show

Allelic Composition: Braftm1Mmcm/Braf+,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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