ENSMUSG00000061578


Mus musculus

Features
Gene ID: ENSMUSG00000061578
  
Biological name :Ksr2
  
Synonyms : kinase suppressor of ras 2 / Ksr2
  
Possible biological names infered from orthology : Q6VAB6
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 117414000
Gene end: 117775003
  
Corresponding Affymetrix probe sets: 10524889 (MoGene1.0st)   1446312_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000137670
NCBI entrez gene - 333050     See in Manteia.
MGI - MGI:3610315
RefSeq - XM_006530395
RefSeq - NM_001312914
RefSeq - XM_006530393
RefSeq - XM_006530394
RefSeq Peptide - NP_001299843
swissprot - M0QW59
Ensembl - ENSMUSG00000061578
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ksr2ENSDARG00000094526Danio rerio
 si:ch73-263f13.1ENSDARG00000094172Danio rerio
 KSR2ENSGALG00000020905Gallus gallus
 KSR2ENSG00000171435Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ksr1 / Q61097 / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA. / Q8IVT5* / kinase suppressor of ras 1*ENSMUSG0000001833447
Braf / P28028 / Serine/threonine-protein kinase B-raf / P15056* / B-Raf proto-oncogene, serine/threonine kinase*ENSMUSG0000000241319
Raf1 / Q99N57 / Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049* / Raf-1 proto-oncogene, serine/threonine kinase*ENSMUSG0000000044116
Araf / P04627 / Serine/threonine-protein kinase A-Raf / P10398* / A-Raf proto-oncogene, serine/threonine kinase*ENSMUSG0000000112716


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR025561  Kinase suppressor of RAS, SAM-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
MAP2K and MAPK activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Grm1m1Btlr/Grm1m1Btlr
Genetic Background: C57BL/6J-Grm1m1Btlr

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mc4rtm1Lex/Mc4rtm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Ksr2tm2.1Lex/Ksr2tm2.1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mc4rtm1Lex/Mc4rtm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Ksr2tm2.1Lex/Ksr2tm2.1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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