ENSMUSG00000061802


Mus musculus
ciliumventricularArmc4rightdefectventricleseptalrespiratoryheartdevelopmentcellprojectionbindingphysiologydoubleoutletmotilesitusarmadilloarmadillo-likehelicalarmadillo-typefoldgskipdomainsuperfamilymovementregulationbeatfrequencydetermination

Features
Gene ID: ENSMUSG00000061802
  
Biological name :Armc4
  
Synonyms : Armc4 / B2RY50 / Mus musculus armadillo repeat containing 4 (Armc4), mRNA.
  
Possible biological names infered from orthology : armadillo repeat containing 4 / Q5T2S8
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: A1
Gene start: 7088233
Gene end: 7297901
  
Corresponding Affymetrix probe sets: 10457333 (MoGene1.0st)   10457345 (MoGene1.0st)   1456472_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000080028
NCBI entrez gene - 74934     See in Manteia.
MGI - MGI:1922184
RefSeq - XM_011247016
RefSeq - NM_001081393
RefSeq - NM_001357492
RefSeq - XM_006526311
RefSeq - XM_006526312
RefSeq - XM_006526313
RefSeq Peptide - NP_001074862
RefSeq Peptide - NP_001344421
swissprot - B2RY50
Ensembl - ENSMUSG00000061802
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARMC4ENSGALG00000007417Gallus gallus
 ARMC4ENSG00000169126Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Armc3 / A2AU72 / Armadillo repeat-containing protein 3 / Q5W041* / armadillo repeat containing 3*ENSMUSG0000003768313


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR023231  GSKIP domain superfamily


Gene Ontology (GO)
movement of cell or subcellular componentmicrotubule-based processanatomical structure developmentcellular component organizationcellular component biogenesismovement of cell or subcellular componentmicrotubule-based processanatomical structure developmentcellular component organizationcellular component biogenesismovement of cell or subcellular componentmicrotubule-based processanatomical structure developmentcellular component organizationcellular component biogenesismovement of cell or subcellular componentmicrotubule-based processanatomical structure developmentcellular component organizationcellular component biogenesismovement of cell or subcellular componentmicrotubule-based processanatomical structure developmentcellular component organizationcellular component biogenesismovement of cell or subcellular componentmicrotubule-based processanatomical structure developmentcellular component organizationcellular component biogenesismovement of cell or subcellular componentmicrotubule-based processanatomical structure developmentcellular component organizationcellular component biogenesismovement of cell or subcellular componentmicrotubule-based processanatomical structure developmentcellular component organizationcellular component biogenesismovement of cell or subcellular componentmicrotubule-based processanatomical structure developmentcellular component organizationcellular component biogenesismovement of cell or subcellular componentmicrotubule-based processanatomical structure developmentcellular component organizationcellular component biogenesismovement of cell or subcellumovement of cell or subcellular componentmicrotubule-based processmicrotubule-based processanatomical structure developanatomical structure developmentcellular component organizatcellular component organizationcellular component biogenesicellular component biogenesis
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellcellorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0003341 cilium movement IEA
 biological_processGO:0003356 regulation of cilium beat frequency IEA
 biological_processGO:0007368 determination of left/right symmetry IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0021591 ventricular system development IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0036158 outer dynein arm assembly IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0005930 axoneme IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0097546 ciliary base IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
cardiovascular system phenotypeimmune system phenotypehematopoietic system phenotypenervous system phenotyperespiratory system phenotypemortality/aginggrowth/size phenotypemuscle phenotypedigestive/alimentary phenotypecellular phenotypecardiovascular system phenotypeimmune system phenotypehematopoietic system phenotypenervous system phenotyperespiratory system phenotypemortality/aginggrowth/size phenotypemuscle phenotypedigestive/alimentary phenotypecellular phenotypecardiovascular system phenotypeimmune system phenotypehematopoietic system phenotypenervous system phenotyperespiratory system phenotypemortality/aginggrowth/size phenotypemuscle phenotypedigestive/alimentary phenotypecellular phenotypecardiovascular system phenotypeimmune system phenotypehematopoietic system phenotypenervous system phenotyperespiratory system phenotypemortality/aginggrowth/size phenotypemuscle phenotypedigestive/alimentary phenotypecellular phenotypecardiovascular system phenotypeimmune system phenotypehematopoietic system phenotypenervous system phenotyperespiratory system phenotypemortality/aginggrowth/size phenotypemuscle phenotypedigestive/alimentary phenotypecellular phenotypecardiovascular system phenotypeimmune system phenotypehematopoietic system phenotypenervous system phenotyperespiratory system phenotypemortality/aginggrowth/size phenotypemuscle phenotypedigestive/alimentary phenotypecellular phenotypecardiovascular system phenotypeimmune system phenotypehematopoietic system phenotypenervous system phenotyperespiratory system phenotypemortality/aginggrowth/size phenotypemuscle phenotypedigestive/alimentary phenotypecellular phenotypecardiovascular system phenotypeimmune system phenotypehematopoietic system phenotypenervous system phenotyperespiratory system phenotypemortality/aginggrowth/size phenotypemuscle phenotypedigestive/alimentary phenotypecellular phenotypecardiovascular system phenotypeimmune system phenotypehematopoietic system phenotypenervous system phenotyperespiratory system phenotypemortality/aginggrowth/size phenotypemuscle phenotypedigestive/alimentary phenotypecellular phenotypecardiovascular system phenotypeimmune system phenotypehematopoietic system phenotypenervous system phenotyperespiratory system phenotypemortality/aginggrowth/size phenotypemuscle phenotypedigestive/alimentary phenotypecellular phenotypecardiovascularcardiovascular system phenotypeimmune system immune system phenotypehematopoietic hematopoietic system phenotypenervous systemnervous system phenotyperespiratory syrespiratory system phenotypemortality/aginmortality/aginggrowth/size phgrowth/size phenotypemuscle phenotymuscle phenotypedigestive/alimdigestive/alimentary phenotypecellular phenocellular phenotype
IDPhenotypeDefinition Genetic BG
 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnah11b2b598Clo/Dnah11b2b598Clo
Genetic Background: C57BL/6J-Dnah11b2b598Clo

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Adartm2Knk/Adar+
Genetic Background: chimera involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000644 dextrocardia "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnah11b2b598Clo/Dnah11b2b598Clo
Genetic Background: C57BL/6J-Dnah11b2b598Clo

Allelic Composition: Armc4b2b227.1Clo/Armc4b2b227.1Clo
Genetic Background: C57BL/6J-Armc4b2b227.1Clo

 MP:0000650 mesocardia "cardiac apex pointing to the middle as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Armc4b2b227.1Clo/Armc4b2b227.1Clo
Genetic Background: C57BL/6J-Armc4b2b227.1Clo

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Adartm2Knk/Adar+
Genetic Background: chimera involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Dnah11b2b598Clo/Dnah11b2b598Clo
Genetic Background: C57BL/6J-Dnah11b2b598Clo

 MP:0001943 abnormal respiration "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adartm2Knk/Adar+
Genetic Background: chimera involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnah11b2b598Clo/Dnah11b2b598Clo
Genetic Background: C57BL/6J-Dnah11b2b598Clo

 MP:0004133 heterotaxia "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnah11b2b598Clo/Dnah11b2b598Clo
Genetic Background: C57BL/6J-Dnah11b2b598Clo

Allelic Composition: Armc4b2b227.1Clo/Armc4b2b227.1Clo
Genetic Background: C57BL/6J-Armc4b2b227.1Clo

 MP:0004158 right aortic arch "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnah11b2b598Clo/Dnah11b2b598Clo
Genetic Background: C57BL/6J-Dnah11b2b598Clo

 MP:0004880 lung cysts 
Show

Allelic Composition: Armc4b2b227.1Clo/Armc4b2b227.1Clo
Genetic Background: C57BL/6J-Armc4b2b227.1Clo

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dnah11b2b598Clo/Dnah11b2b598Clo
Genetic Background: C57BL/6J-Dnah11b2b598Clo

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Adartm2Knk/Adar+
Genetic Background: chimera involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Armc4b2b227.1Clo/Armc4b2b227.1Clo
Genetic Background: C57BL/6J-Armc4b2b227.1Clo

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
Show

Allelic Composition: Dnah11b2b598Clo/Dnah11b2b598Clo
Genetic Background: C57BL/6J-Dnah11b2b598Clo

 MP:0010420 muscular ventricular septal defect "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]
Show

Allelic Composition: Dnah11b2b598Clo/Dnah11b2b598Clo
Genetic Background: C57BL/6J-Dnah11b2b598Clo

 MP:0010808 right-sided stomach "stomach is present on the right side of the body instead of the left" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Armc4b2b227.1Clo/Armc4b2b227.1Clo
Genetic Background: C57BL/6J-Armc4b2b227.1Clo

 MP:0011050 abnormal respiratory motile cilium morphology "any structural anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnah11b2b598Clo/Dnah11b2b598Clo
Genetic Background: C57BL/6J-Dnah11b2b598Clo

 MP:0011055 abnormal respiratory motile cilium physiology "any functional anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract; may include alterations in ciliary beating pattern or frequency" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnah11b2b598Clo/Dnah11b2b598Clo
Genetic Background: C57BL/6J-Dnah11b2b598Clo

Allelic Composition: Armc4b2b227.1Clo/Armc4b2b227.1Clo
Genetic Background: C57BL/6J-Armc4b2b227.1Clo

 MP:0011250 abdominal situs ambiguus "an abnormality in which the abdominal organs are positioned in such a way with respect to each other and the left-right axis as to be not clearly lateralised and thus have neither the usual, or normal (situs solitus), nor the mirror-imaged (situs inversus) arrangements" [MGI:csmith, PMID:18039396]
Show

Allelic Composition: Dnah11b2b598Clo/Dnah11b2b598Clo
Genetic Background: C57BL/6J-Dnah11b2b598Clo

 MP:0011252 situs inversus totalis "the complete right to left reversal (transposition) of the thoracic and abdominal organs, including the heart (dextrocardia)" [MGI:csmith]
Show

Allelic Composition: Dnah11b2b598Clo/Dnah11b2b598Clo
Genetic Background: C57BL/6J-Dnah11b2b598Clo

Allelic Composition: Armc4b2b227.1Clo/Armc4b2b227.1Clo
Genetic Background: C57BL/6J-Armc4b2b227.1Clo

 MP:0011649 immotile respiratory cilia "failure of the multiple epithelial tiny, motile hair-like projections of the repiratory tract epithelium to beat with a characteristic whip-like pattern in order to promote transport of fluids and other cells across the epithelium of the respiratory tract" [MGI:csmith]
Show

Allelic Composition: Dnah11b2b598Clo/Dnah11b2b598Clo
Genetic Background: C57BL/6J-Dnah11b2b598Clo

Allelic Composition: Armc4b2b227.1Clo/Armc4b2b227.1Clo
Genetic Background: C57BL/6J-Armc4b2b227.1Clo

 MP:0011666 double outlet right ventricle, ventricular defect committed to aorta "a form of DORV in which a ventricular septal defect is located just below the aorta; the left ventricular outflow is directed toward the aorta, resulting in aortic oxygen saturations that exceed pulmonary saturations; pulmonary stenosis is also often present" [MGI:csmith]
Show

Allelic Composition: Dnah11b2b598Clo/Dnah11b2b598Clo
Genetic Background: C57BL/6J-Dnah11b2b598Clo

 MP:0011683 dual inferior vena cava "presence of two inferior vena cavae, often resulting from the persistence of both supracardinal veins during development; the two structures may be symmetric or asymmetric but typically join together at the renal vein" [MGI:csmith, PMID:10835118]
Show

Allelic Composition: Dnah11b2b598Clo/Dnah11b2b598Clo
Genetic Background: C57BL/6J-Dnah11b2b598Clo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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