Manteia - Molecule gene

ENSMUSG00000062563

Mus musculus

Features

Gene ID:	ENSMUSG00000062563

Biological name :	Cys1

Synonyms :	Cys1 / cystin 1

Possible biological names infered from orthology :	Q717R9

Species:	Mus musculus

Chr. number:	12
Strand:	-1
Band:	A1.3
Gene start:	24665833
Gene end:	24681813

Corresponding Affymetrix probe sets:	10399680 (MoGene1.0st) 1419070_at (Mouse Genome 430 2.0 Array) 1419071_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000141121 Ensembl peptide - ENSMUSP00000134701 Ensembl peptide - ENSMUSP00000140759 Ensembl peptide - ENSMUSP00000073796 Ensembl peptide - ENSMUSP00000126787 Ensembl peptide - ENSMUSP00000133902 Ensembl peptide - ENSMUSP00000134522 NCBI entrez gene - 12879 See in Manteia. MGI - MGI:2177632 RefSeq - XM_006514952 RefSeq - NM_001004455 RefSeq - NM_001161807 RefSeq - NM_138686 RefSeq - XM_006514951 RefSeq Peptide - NP_001004455 RefSeq Peptide - NP_001155279 RefSeq Peptide - NP_619627 swissprot - G3UZZ7 swissprot - A0A0R4J216 Ensembl - ENSMUSG00000062563

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
CYS1	ENSG00000205795	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID

Name

No match

Gene Ontology (GO)

Type

GO ID

Term

Ev.Code

No match

Pathways (from Reactome)

Pathway description

Trafficking of myristoylated proteins to the cilium

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000042	abnormal organ of Corti	"abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: D2J.B6(Cg)-Cys1^cpk
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0000522	cysts in kidney cortex	"abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: involves: C57BL/6J * CD-1 Allelic Composition: Cys1^cpk/Cys1^cpk,Lgals3^tm1Ftl/Lgals3^tm1Ftl Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Cys1^cpk/Cys1^cpk,Lgals3^tm1Ftl/Lgals3^tm1Ftl Genetic Background: B6.Cg-Cys1^cpk Lgals3^tm1Ftl
MP:0000694	spleen hypoplasia	"small size due to reduced cell number in the spleen" [J:43971]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: B6(Cg)-Cys1^cpk/JUnc
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: B6(Cg)-Cys1^cpk/JUnc
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: involves: C57BL/6J * CD-1
MP:0001270	distended abdomen	"abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: B6(Cg)-Cys1^cpk/JUnc
MP:0001436	abnormal suckling behavior	"reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: C.B6(Cg)-Cys1^cpk
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: B6(Cg)-Cys1^cpk/JUnc
MP:0001860	liver inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Cys1^cpk/Cys1^cpk,Lgals3^tm1Ftl/Lgals3^tm1Ftl Genetic Background: involves: 129/Sv * C57BL/6
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: B6(Cg)-Cys1^cpk/JUnc
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: B6(Cg)-Cys1^cpk/JUnc
MP:0002928	abnormal bile duct morphology	"malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: D2J.B6(Cg)-Cys1^cpk
MP:0003068	enlarged kidney	"larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: B6(Cg)-Cys1^cpk/JUnc Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: involves: C57BL/6J * CD-1 Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: C.B6(Cg)-Cys1^cpk Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: D2J.B6(Cg)-Cys1^cpk Allelic Composition: Cux1^tm1Ejn/Cux1^tm1Ejn,Cys1^cpk/Cys1^cpk Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0003253	bile duct dilation	"abnormal distention of the bile ducts due to accumulation of fluid or bile" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: C.B6(Cg)-Cys1^cpk
MP:0003266	biliary cysts	"the appearance of fluid-filled sacs within the bile ducts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: involves: C57BL/6J * CD-1 Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: C.B6(Cg)-Cys1^cpk
MP:0003327	liver cysts	"abnormal membranous sacs in any portion of the liver" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: involves: C57BL/6J * CD-1 Allelic Composition: Cys1^cpk/Cys1⁺ Genetic Background: involves: C57BL/6J * CD-1 Allelic Composition: Cys1^cpk/Cys1⁺ Genetic Background: C.B6(Cg)-Cys1^cpk
MP:0003333	liver fibrosis	"invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: C.B6(Cg)-Cys1^cpk Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: D2J.B6(Cg)-Cys1^cpk Allelic Composition: Cys1^cpk/Cys1⁺ Genetic Background: involves: C57BL/6J * CD-1 Allelic Composition: Cys1^cpk/Cys1⁺ Genetic Background: C.B6(Cg)-Cys1^cpk
MP:0003334	pancreatic fibrosis	"invasion of fibrous connective tissue into the pancreas, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: C.B6(Cg)-Cys1^cpk Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: D2J.B6(Cg)-Cys1^cpk
MP:0003336	pancreatic cysts	"the appearance of fluid-filled sacs within the pancreas" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: involves: C57BL/6J * CD-1 Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: 129.B6-Cys1^cpk
MP:0003637	cochlear ganglion hypoplasia	"reduced numbers of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: D2J.B6(Cg)-Cys1^cpk
MP:0003675	kidney cysts	"abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: B6(Cg)-Cys1^cpk/JUnc Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: involves: C57BL/6J * CD-1 Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: C.B6(Cg)-Cys1^cpk Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: D2J.B6(Cg)-Cys1^cpk Allelic Composition: Cys1^cpk/Cys1⁺ Genetic Background: involves: C57BL/6J * CD-1 Allelic Composition: Cys1^cpk/Cys1^cpk,Lgals3^tm1Ftl/Lgals3^tm1Ftl Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: 129.B6-Cys1^cpk Allelic Composition: Cys1^cpk/Cys1^cpk,Lgals3^tm1Ftl/Lgals3^tm1Ftl Genetic Background: B6.Cg-Cys1^cpk Lgals3^tm1Ftl Allelic Composition: Cux1^tm1Ejn/Cux1^tm1Ejn,Cys1^cpk/Cys1^cpk Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0003825	abnormal pillar cell morphology	"abnormalities of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: D2J.B6(Cg)-Cys1^cpk
MP:0003917	increased kidney weight	"greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: D2J.B6(Cg)-Cys1^cpk Allelic Composition: Cys1^cpk/Cys1^cpk,Lgals3^tm1Ftl/Lgals3^tm1Ftl Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: 129.B6-Cys1^cpk Allelic Composition: Cux1^tm1Ejn/Cux1^tm1Ejn,Cys1^cpk/Cys1^cpk Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0004393	abnormal cochlear inner hair cell morphology	"any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell s surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: D2J.B6(Cg)-Cys1^cpk
MP:0004403	absent cochlear outer hair cells	"absence of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: D2J.B6(Cg)-Cys1^cpk
MP:0005202	lethargy	"mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: B6(Cg)-Cys1^cpk/JUnc Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: D2J.B6(Cg)-Cys1^cpk
MP:0005553	increased circulating creatinine level	"greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: B6(Cg)-Cys1^cpk/JUnc Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: D2J.B6(Cg)-Cys1^cpk
MP:0005565	increased blood urea nitrogen level	"high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: B6(Cg)-Cys1^cpk/JUnc Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: involves: C57BL/6J * CD-1 Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: C.B6(Cg)-Cys1^cpk Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: D2J.B6(Cg)-Cys1^cpk Allelic Composition: Cux1^tm1Ejn/Cux1^tm1Ejn,Cys1^cpk/Cys1^cpk Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0006021	abnormal Reissner membrane morphology	"any strutural alteration in Reissner s membrane which separates the cochlear duct from the vestibular canal, i.e. the endolymph of the scala media from the perilymph of the scala vestibuli; the Reissner membrane consists of squamous epithelial cells with microvilli toward the ductus, a basement membrane, and a thin layer of connective tissue toward the scala. " [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: D2J.B6(Cg)-Cys1^cpk
MP:0008528	polycystic kidney	"the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0009144	dilated pancreatic duct	"an increase in volume of the luminal space of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A03.734.667]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: C.B6(Cg)-Cys1^cpk Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: D2J.B6(Cg)-Cys1^cpk
MP:0009145	abnormal pancreatic acinus morphology	"any structural anomaly of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: D2J.B6(Cg)-Cys1^cpk
MP:0009157	ectopic pancreatic acinar cells	"abnormal position of one or more of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: D2J.B6(Cg)-Cys1^cpk
MP:0009173	absent pancreatic islets	"absence of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: C.B6(Cg)-Cys1^cpk Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: D2J.B6(Cg)-Cys1^cpk
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0011376	abnormal kidney corticomedullary boundary morphology	"any structural anomaly of the region demarcating the renal medulla from the surrounding cortex; end-stage renal failure may be associated with loss of the normal corticomedullary boundary" [MGI:anna]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA
MP:0011413	colorless urine	"absence of the usual straw-coloration of the urine" [MGI:anna]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: B6(Cg)-Cys1^cpk/JUnc
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Cys1^cpk/Cys1^cpk Genetic Background: D2J.B6(Cg)-Cys1^cpk

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000025035	Arl3 / Q9WUL7 / ADP-ribosylation factor-like protein 3 / P36405* / ADP ribosylation factor like GTPase 3*	/ complex / reaction
ENSMUSG00000046562	Q8C4B4 / Unc119b / unc-119 lipid binding chaperone B / A6NIH7*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr