ENSMUSG00000064224


Mus musculus

Features
Gene ID: ENSMUSG00000064224
  
Biological name :Gsdma3
  
Synonyms : Gasdermin-A3 / Gsdma3 / Q5Y4Y6
  
Possible biological names infered from orthology : gasdermin A / GSDMA / Q96QA5
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 98626360
Gene end: 98638226
  
Corresponding Affymetrix probe sets: 10380956 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000073022
Ensembl peptide - ENSMUSP00000103132
NCBI entrez gene - 450219     See in Manteia.
MGI - MGI:3044668
RefSeq - NM_001007461
RefSeq - XM_006533674
RefSeq - XM_017314644
RefSeq Peptide - NP_001007462
swissprot - Q5Y4Y6
swissprot - Z4YKL5
Ensembl - ENSMUSG00000064224
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GSDMAENSGALG00000013495Gallus gallus
 GSDMAENSG00000167914Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gsdma / Q9EST1 / Gasdermin-A / Q96QA5*ENSMUSG0000001720478
Gsdma2 / Q32M21 / Gasdermin-A2 / GSDMA* / Q96QA5* / gasdermin A*ENSMUSG0000001721176
Gsdmd / Q9D8T2 / Gasdermin-D Gasdermin-D, N-terminal Gasdermin-D, C-terminal / P57764* / gasdermin D*ENSMUSG0000002257530
Gsdmc / Q99NB5 / Gasdermin-C / Q9BYG8*ENSMUSG0000007902530
Gsdmc2 / Q2KHK6 / Gasdermin-C2 / GSDMC* / Q9BYG8* / gasdermin C*ENSMUSG0000005629329
Gsdmc3 / Q8CB12 / Gasdermin-C3 / GSDMC* / Q9BYG8* / gasdermin C*ENSMUSG0000005582728
Gsdmc4 / Q3TR54 / Gasdermin-C4 / GSDMC* / Q9BYG8* / gasdermin C*ENSMUSG0000005574827


Protein motifs (from Interpro)
Interpro ID Name
 IPR007677  Gasdermin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001942 hair follicle development IMP
 biological_processGO:0001949 sebaceous gland cell differentiation IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0012501 programmed cell death IEA
 biological_processGO:0031069 hair follicle morphogenesis IMP
 biological_processGO:0035019 somatic stem cell population maintenance IMP
 biological_processGO:0036331 avascular cornea development in camera-type eye IMP
 biological_processGO:0042633 hair cycle IMP
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043588 skin development IMP
 biological_processGO:0051886 negative regulation of timing of anagen IDA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000017 big ears "outer ears of a greater than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gsdma3M1Btlr/Gsdma3+
Genetic Background: either: C57BL/6J-Gsdma3M1Btlr or (involves: C3H * C57BL/6J)

Allelic Composition: Gsdma3M1Btlr/Gsdma3M1Btlr
Genetic Background: either: C57BL/6J-Gsdma3M1Btlr or (involves: C3H * C57BL/6J)

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
Show

Allelic Composition: Prickle1tm1Nue/Prickle1+,Vangl2Lp/Vangl2+
Genetic Background: involves: C57BL/6J * CBA * LPT/LeJ

Allelic Composition: Gsdma3Rim3/Gsdma3+
Genetic Background: involves: C57BL/10J * DBA/2J

 MP:0000397 abnormal guard hair "anomalies of truncal hairs that contain two air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

Allelic Composition: Gsdma3Bsk/Gsdma3+
Genetic Background: Not Specified

Allelic Composition: Gsdma3Bsk/Gsdma3Bsk
Genetic Background: Not Specified

Allelic Composition: Gsdma3Fgn/Gsdma3+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Gsdma3Mhdaclp1/Gsdma3Mhdaclp1
Genetic Background: C3HeB/FeJ-Gsdma3Mhdaclp1

Allelic Composition: Gsdma3Mhdaclp1/Gsdma3+
Genetic Background: C3HeB/FeJ-Gsdma3Mhdaclp1

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Gsdma3Bsk/Gsdma3+
Genetic Background: Not Specified

Allelic Composition: Gsdma3Bsk/Gsdma3Bsk
Genetic Background: Not Specified

Allelic Composition: Gsdma3Rim3/Gsdma3+
Genetic Background: involves: C57BL/10J * DBA/2J

 MP:0000423 delayed hair regrowth "slow initiation and asynchrony of the hair growth cycle (anagen) after catagen phase " [J:61509]
Show

Allelic Composition: Gsdma3Ae/Gsdma3+
Genetic Background: involves: C57BL/6J * CAST/Ei

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
Show

Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Gsdma3Rim3/Gsdma3+
Genetic Background: involves: C57BL/10J * DBA/2J

Allelic Composition: Gsdma3Ae/Gsdma3+
Genetic Background: involves: C57BL/6J * CAST/Ei

 MP:0000648 absent sebaceous gland "missing the holocrine glands of the dermis that secrete sebum into the hair follicles" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
Show

Allelic Composition: Gsdma3Mhdaclp1/Gsdma3Mhdaclp1
Genetic Background: C3HeB/FeJ-Gsdma3Mhdaclp1

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gsdma3Ae/Gsdma3+
Genetic Background: involves: C57BL/6J * CAST/Ei

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gsdma3Ae/Gsdma3+
Genetic Background: involves: C57BL/6J * CAST/Ei

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
Show

Allelic Composition: Gsdma3Ae/Gsdma3+
Genetic Background: involves: C57BL/6J * CAST/Ei

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Htttm1Hay/Htt+
Genetic Background: involves: C57BL/6J

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
Show

Allelic Composition: Sun1tm1Mhan/Sun1tm1Mhan
Genetic Background: B6.129S6-Sun1tm1Mhan

 MP:0001200 thick skin "greater depth of skin " [J:47225]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

Allelic Composition: Gsdma3Bsk/Gsdma3+
Genetic Background: Not Specified

Allelic Composition: Gsdma3Bsk/Gsdma3Bsk
Genetic Background: Not Specified

 MP:0001211 wrinkled skin "irregular folds and/or indentations on the skin" [J:19212]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

Allelic Composition: Gsdma3Bsk/Gsdma3+
Genetic Background: Not Specified

Allelic Composition: Gsdma3Bsk/Gsdma3Bsk
Genetic Background: Not Specified

Allelic Composition: Gsdma3M1Btlr/Gsdma3+
Genetic Background: either: C57BL/6J-Gsdma3M1Btlr or (involves: C3H * C57BL/6J)

Allelic Composition: Gsdma3M1Btlr/Gsdma3M1Btlr
Genetic Background: either: C57BL/6J-Gsdma3M1Btlr or (involves: C3H * C57BL/6J)

Allelic Composition: Gsdma3Ae/Gsdma3Ae
Genetic Background: involves: C57BL/6J * CAST/Ei

Allelic Composition: Gsdma3Ae/Gsdma3+
Genetic Background: involves: C57BL/6J * CAST/Ei

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Sun1tm1Mhan/Sun1tm1Mhan
Genetic Background: B6.129S6-Sun1tm1Mhan

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prickle1tm1Nue/Prickle1+,Vangl2Lp/Vangl2+
Genetic Background: involves: C57BL/6J * CBA * LPT/LeJ

Allelic Composition: Gsdma3Rim3/Gsdma3+
Genetic Background: involves: C57BL/10J * DBA/2J

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Prickle1tm1Nue/Prickle1+,Vangl2Lp/Vangl2+
Genetic Background: involves: C57BL/6J * CBA * LPT/LeJ

Allelic Composition: Gsdma3Rim3/Gsdma3+
Genetic Background: involves: C57BL/10J * DBA/2J

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Gsdma3Ae/Gsdma3+
Genetic Background: involves: C57BL/6J * CAST/Ei

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Gsdma3Rim3/Gsdma3Rim3
Genetic Background: involves: C57BL/10J * DBA/2J

Allelic Composition: Gsdma3Rim3/Gsdma3+
Genetic Background: involves: C57BL/10J * DBA/2J

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Gsdma3M1Btlr/Gsdma3+
Genetic Background: either: C57BL/6J-Gsdma3M1Btlr or (involves: C3H * C57BL/6J)

Allelic Composition: Gsdma3M1Btlr/Gsdma3M1Btlr
Genetic Background: either: C57BL/6J-Gsdma3M1Btlr or (involves: C3H * C57BL/6J)

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

Allelic Composition: Gsdma3Bsk/Gsdma3+
Genetic Background: Not Specified

Allelic Composition: Gsdma3Bsk/Gsdma3Bsk
Genetic Background: Not Specified

Allelic Composition: Gsdma3M1Btlr/Gsdma3M1Btlr
Genetic Background: either: C57BL/6J-Gsdma3M1Btlr or (involves: C3H * C57BL/6J)

Allelic Composition: Gsdma3Rim3/Gsdma3Rim3
Genetic Background: involves: C57BL/10J * DBA/2J

Allelic Composition: Gsdma3Rim3/Gsdma3+
Genetic Background: involves: C57BL/10J * DBA/2J

Allelic Composition: Gsdma3Ae/Gsdma3Ae
Genetic Background: involves: C57BL/6J * CAST/Ei

Allelic Composition: Gsdma3Ae/Gsdma3+
Genetic Background: involves: C57BL/6J * CAST/Ei

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Htttm1Hay/Htt+
Genetic Background: involves: C57BL/6J

Allelic Composition: Gsdma3Re-Den/Gsdma3Re-Den
Genetic Background: C3HeB/FeJ

Allelic Composition: Gsdma3Ae/Gsdma3Ae
Genetic Background: involves: C57BL/6J * CAST/Ei

Allelic Composition: Gsdma3Ae/Gsdma3+
Genetic Background: involves: C57BL/6J * CAST/Ei

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gsdma3Rim3/Gsdma3Rim3
Genetic Background: involves: C57BL/10J * DBA/2J

Allelic Composition: Gsdma3Rim3/Gsdma3+
Genetic Background: involves: C57BL/10J * DBA/2J

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Gsdma3Ae/Gsdma3Ae
Genetic Background: involves: C57BL/6J * CAST/Ei

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm1Hay/Htt+
Genetic Background: involves: C57BL/6J

Allelic Composition: Gsdma3Rim3/Gsdma3+
Genetic Background: involves: C57BL/10J * DBA/2J

 MP:0002832 coarse hair "hair shafts that are twisted or coiled and are of uneven thickness produce an overall rugged or uneven appearance and roughness to the touch" [llw2:Linda Washburn , Mouse Genome Informatics Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:56826]
Show

Allelic Composition: Gsdma3M1Btlr/Gsdma3+
Genetic Background: either: C57BL/6J-Gsdma3M1Btlr or (involves: C3H * C57BL/6J)

Allelic Composition: Gsdma3M1Btlr/Gsdma3M1Btlr
Genetic Background: either: C57BL/6J-Gsdma3M1Btlr or (involves: C3H * C57BL/6J)

 MP:0002881 long hair "increased average length of the coat hairs" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gsdma3M1Btlr/Gsdma3+
Genetic Background: either: C57BL/6J-Gsdma3M1Btlr or (involves: C3H * C57BL/6J)

Allelic Composition: Gsdma3M1Btlr/Gsdma3M1Btlr
Genetic Background: either: C57BL/6J-Gsdma3M1Btlr or (involves: C3H * C57BL/6J)

 MP:0003095 abnormal corneal stroma development "anomalous differentiaton of the lamellated connective tissue layer of the cornea" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:81616]
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Allelic Composition: Gsdma3Rim3/Gsdma3Rim3
Genetic Background: involves: C57BL/10J * DBA/2J

Allelic Composition: Gsdma3Rim3/Gsdma3+
Genetic Background: involves: C57BL/10J * DBA/2J

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm1Hay/Htt+
Genetic Background: involves: C57BL/6J

 MP:0003810 abnormal hair cuticle "anomalies in the thin, smooth and glossy outer protective cell layer of hair shaft" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gsdma3Ae/Gsdma3+
Genetic Background: involves: C57BL/6J * CAST/Ei

 MP:0003853 dry skin "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sun1tm1Mhan/Sun1tm1Mhan
Genetic Background: B6.129S6-Sun1tm1Mhan

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gsdma3Ae/Gsdma3+
Genetic Background: involves: C57BL/6J * CAST/Ei

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gsdma3Ae/Gsdma3Ae
Genetic Background: involves: C57BL/6J * CAST/Ei

Allelic Composition: Gsdma3Ae/Gsdma3+
Genetic Background: involves: C57BL/6J * CAST/Ei

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gsdma3Rim3/Gsdma3Rim3
Genetic Background: involves: C57BL/10J * DBA/2J

Allelic Composition: Gsdma3Rim3/Gsdma3+
Genetic Background: involves: C57BL/10J * DBA/2J

 MP:0008858 abnormal hair cycle anagen phase "anomaly in the growth phase of the hair cycle" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gsdma3Rim3/Gsdma3+
Genetic Background: involves: C57BL/10J * DBA/2J

 MP:0008859 abnormal hair cycle catagen phase "anomaly in the phase of the hair growth cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored hair is produced" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gsdma3Ae/Gsdma3+
Genetic Background: involves: C57BL/6J * CAST/Ei

 MP:0009004 progressive hair loss "thinning of hair (coat) over time, usually in a defined pattern, until entirely gone with no recurrent growth" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gsdma3M1Btlr/Gsdma3+
Genetic Background: either: C57BL/6J-Gsdma3M1Btlr or (involves: C3H * C57BL/6J)

Allelic Composition: Gsdma3M1Btlr/Gsdma3M1Btlr
Genetic Background: either: C57BL/6J-Gsdma3M1Btlr or (involves: C3H * C57BL/6J)

Allelic Composition: Gsdma3Ae/Gsdma3Ae
Genetic Background: involves: C57BL/6J * CAST/Ei

Allelic Composition: Gsdma3Ae/Gsdma3+
Genetic Background: involves: C57BL/6J * CAST/Ei

Allelic Composition: Gsdma3M2Btlr/Gsdma3M2Btlr
Genetic Background: involves: C57BL/6J

 MP:0009351 thin hair shaft "the average diameter of coat hair is less than the average diameter of hair from normal individuals" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gsdma3Ae/Gsdma3+
Genetic Background: involves: C57BL/6J * CAST/Ei

 MP:0009600 hypergranulosis "increased thickness of the granular layer of the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gsdma3Rim3/Gsdma3Rim3
Genetic Background: involves: C57BL/10J * DBA/2J

Allelic Composition: Gsdma3Rim3/Gsdma3+
Genetic Background: involves: C57BL/10J * DBA/2J

 MP:0009742 increased corneal stroma thickness "increased width of the lamellated connective tissue layer of the cornea" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gsdma3Rim3/Gsdma3Rim3
Genetic Background: involves: C57BL/10J * DBA/2J

 MP:0009759 abnormal hair follicle bulge "an anomaly in the area located in the bottom of the permanent portion of a resting (telogen) hair follicle where the cells of the external root sheath of the hair follicle are contiguous with the basal layer of the epidermis; this portion of the follicle is involved in the generation of a new hair at the onset of the hair growth cycle (anagen)" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gsdma3Ae/Gsdma3+
Genetic Background: involves: C57BL/6J * CAST/Ei

 MP:0009859 eye opacity "changes in the eye grossly observed as a milky or cloudy appearance that may be progressive and persistent throughout life" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gsdma3M2Btlr/Gsdma3M2Btlr
Genetic Background: involves: C57BL/6J

 MP:0010678 abnormal skin adnexa morphology "any structural anomaly of the tissue or structures associated with or embedded in the skin such as hair and hair follicles, sweat glands, sebaceous glands and claws or nails" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gsdma3Ae/Gsdma3+
Genetic Background: involves: C57BL/6J * CAST/Ei

 MP:0011585 decreased alkaline phosphatase activity "reduced ability to catalyze the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum" [GO:0004035]
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Allelic Composition: Gsdma3Mhdaclp1/Gsdma3Mhdaclp1
Genetic Background: C3HeB/FeJ-Gsdma3Mhdaclp1

Allelic Composition: Gsdma3Mhdaclp1/Gsdma3+
Genetic Background: C3HeB/FeJ-Gsdma3Mhdaclp1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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