ENSMUSG00000064272


Mus musculus

Features
Gene ID: ENSMUSG00000064272
  
Biological name :Gpbar1
  
Synonyms : Gpbar1 / G protein-coupled bile acid receptor 1 / Q80SS6
  
Possible biological names infered from orthology : Q8TDU6
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C3
Gene start: 74278550
Gene end: 74279624
  
Corresponding Affymetrix probe sets: 10347307 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000077135
NCBI entrez gene - 227289     See in Manteia.
MGI - MGI:2653863
RefSeq - NM_174985
RefSeq Peptide - NP_778150
swissprot - Q14AA9
swissprot - Q80SS6
Ensembl - ENSMUSG00000064272
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpbar1ENSDARG00000023302Danio rerio
 GPBAR1ENSG00000179921Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0038183 bile acid signaling pathway IEA
 biological_processGO:2000810 regulation of bicellular tight junction assembly IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity ISO
 molecular_functionGO:0038181 bile acid receptor activity ISO


Pathways (from Reactome)
Pathway description
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten
Genetic Background: B6.129S2-Slc34a1tm1Hten/J

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H

 MP:0002830 gallstones "caliculi in the gallbladder or a bile duct; chemical composition of cholesterol, calcium carbonate or calcium bilirubinate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

 MP:0002929 abnormal bile duct development "incomplete or aberrant differentiation of the channels that secrete bile from the liver to the gall bladder and intestines" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

 MP:0004773 abnormal bile composition "any alteration in the chemical make up of the greenish-yellow fluid secreted by the liver; normally contains bile acids and salts such as sodium glycocholate and sodium taurocholate as well as cholesterol, biliverdin and bilirubin, mucus, fat, lecithin, and cells and cellular debris" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

 MP:0005084 abnormal gall bladder morphology "anomalous structure or development of the organ which serves as a storage reservoir for bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(NPHS2-cre)295Lbh/0
Genetic Background: Not Specified

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten
Genetic Background: B6.129S2-Slc34a1tm1Hten/J

 MP:0005365 abnormal bile salt homeostasis "anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86154]
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Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(NPHS2-cre)295Lbh/0
Genetic Background: Not Specified

 MP:0005452 abnormal body fat amount "more or less than the normal total amount of connective tissue composed of fat cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(NPHS2-cre)295Lbh/0
Genetic Background: Not Specified

Allelic Composition: Gpbar1tm1Ktan/Gpbar1+
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
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Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(NPHS2-cre)295Lbh/0
Genetic Background: Not Specified

Allelic Composition: Gpbar1tm1Ktan/Gpbar1+
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten
Genetic Background: B6.129S2-Slc34a1tm1Hten/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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