ENSMUSG00000065529


Mus musculus

Features
Gene ID: ENSMUSG00000065529
  
Biological name :Mir22
  
Synonyms : microRNA 22 / Mir22
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 75463716
Gene end: 75463810
  
Corresponding Affymetrix probe sets: 10378568 (MoGene1.0st)   10378570 (MoGene1.0st)   
  
Cross references: MGI - MGI:2676896
Ensembl - ENSMUSG00000065529
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035195 gene silencing by miRNA IDA
 biological_processGO:0051152 positive regulation of smooth muscle cell differentiation IDA
 molecular_functionGO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cd40lgtm1Parl/Cd40lgtm1Parl,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Mir22tm1.2Dzw/Mir22tm1.2Dzw,Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd40lgtm1Parl/Cd40lgtm1Parl,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL

 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40lgtm1Parl/Cd40lgtm1Parl,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0020135 abnormal heart ventricle wall thickness "anomaly in the depth of the cardiac wall of the heart ventricles" [GOC:NV]
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Allelic Composition: Mir22tm1.2Dzw/Mir22tm1.2Dzw,Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background: involves: C57BL/6 * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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