ENSMUSG00000065540


Mus musculus
regulationMir126acellangiogenesisendothelialdevelopmentvasculargeneinvolvedproliferationlethalitymigrationsilencingerkresponsesproutingedemaincreaseddecreasedcell-matrixadhesionexpressionmirnanotchsignalingpathwaycascadecellularlaminarfluidshear

Features
Gene ID: ENSMUSG00000065540
  
Biological name :Mir126a
  
Synonyms : microRNA 126a / Mir126a
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A3
Gene start: 26591357
Gene end: 26591429
  
Corresponding Affymetrix probe sets: 10470296 (MoGene1.0st)   1421335_a_at (Mouse Genome 430 2.0 Array)   1435823_x_at (Mouse Genome 430 2.0 Array)   1451427_a_at (Mouse Genome 430 2.0 Array)   1451428_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: MGI - MGI:2676811
Ensembl - ENSMUSG00000065540
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
cell adhesionorganic substance metabolic processlocalization of cellmovement of cell or subcellular componentcell communicationcellular response to stimulusanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processresponse to stresstissue migrationresponse to external stimulusregulation of biological qualitycoagulationcell activationepithelial cell proliferationcell adhesionorganic substance metabolic processlocalization of cellmovement of cell or subcellular componentcell communicationcellular response to stimulusanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processresponse to stresstissue migrationresponse to external stimulusregulation of biological qualitycoagulationcell activationepithelial cell proliferationcell adhesionorganic substance metabolic processlocalization of cellmovement of cell or subcellular componentcell communicationcellular response to stimulusanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processresponse to stresstissue migrationresponse to external stimulusregulation of biological qualitycoagulationcell activationepithelial cell proliferationcell adhesionorganic substance metabolic processlocalization of cellmovement of cell or subcellular componentcell communicationcellular response to stimulusanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processresponse to stresstissue migrationresponse to external stimulusregulation of biological qualitycoagulationcell activationepithelial cell proliferationcell adhesionorganic substance metabolic processlocalization of cellmovement of cell or subcellular componentcell communicationcellular response to stimulusanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processresponse to stresstissue migrationresponse to external stimulusregulation of biological qualitycoagulationcell activationepithelial cell proliferationcell adhesionorganic substance metabolic processlocalization of cellmovement of cell or subcellular componentcell communicationcellular response to stimulusanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processresponse to stresstissue migrationresponse to external stimulusregulation of biological qualitycoagulationcell activationepithelial cell proliferationcell adhesionorganic substance metabolic processlocalization of cellmovement of cell or subcellular componentcell communicationcellular response to stimulusanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processresponse to stresstissue migrationresponse to external stimulusregulation of biological qualitycoagulationcell activationepithelial cell proliferationcell adhesionorganic substance metabolic processlocalization of cellmovement of cell or subcellular componentcell communicationcellular response to stimulusanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processresponse to stresstissue migrationresponse to external stimulusregulation of biological qualitycoagulationcell activationepithelial cell proliferationcell adhesionorganic substance metabolic processlocalization of cellmovement of cell or subcellular componentcell communicationcellular response to stimulusanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processresponse to stresstissue migrationresponse to external stimulusregulation of biological qualitycoagulationcell activationepithelial cell proliferationcell adhesionorganic substance metabolic processlocalization of cellmovement of cell or subcellular componentcell communicationcellular response to stimulusanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processresponse to stresstissue migrationresponse to external stimulusregulation of biological qualitycoagulationcell activationepithelial cell proliferationcell adhcell adhesionorganic organic substance metabolic processlocalizalocalization of cellmovementmovement of cell or subcellular componentcell comcell communicationcellularcellular response to stimulusanatomicanatomical structure developmentnitrogennitrogen compound metabolic processcellularcellular metabolic processprimary primary metabolic processresponseresponse to stresstissue mtissue migrationresponseresponse to external stimulusregulatiregulation of biological qualitycoagulatcoagulationcell actcell activationepitheliepithelial cell proliferation
organic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingheterocyclic compound binding
TypeGO IDTermEv.Code
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IDA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0035195 gene silencing by miRNA IDA
 biological_processGO:0045747 positive regulation of Notch signaling pathway IDA
 biological_processGO:0045766 positive regulation of angiogenesis IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0071499 cellular response to laminar fluid shear stress IDA
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IDA
 biological_processGO:1901731 positive regulation of platelet aggregation IMP
 biological_processGO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
 biological_processGO:1904018 positive regulation of vasculature development IMP
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IDA
 molecular_functionGO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
cardiovascular system phenotypehomeostasis/metabolism phenotyperespiratory system phenotypeintegument phenotypereproductive system phenotypevision/eye phenotypehematopoietic system phenotypemortality/agingcellular phenotypecardiovascular system phenotypehomeostasis/metabolism phenotyperespiratory system phenotypeintegument phenotypereproductive system phenotypevision/eye phenotypehematopoietic system phenotypemortality/agingcellular phenotypecardiovascular system phenotypehomeostasis/metabolism phenotyperespiratory system phenotypeintegument phenotypereproductive system phenotypevision/eye phenotypehematopoietic system phenotypemortality/agingcellular phenotypecardiovascular system phenotypehomeostasis/metabolism phenotyperespiratory system phenotypeintegument phenotypereproductive system phenotypevision/eye phenotypehematopoietic system phenotypemortality/agingcellular phenotypecardiovascular system phenotypehomeostasis/metabolism phenotyperespiratory system phenotypeintegument phenotypereproductive system phenotypevision/eye phenotypehematopoietic system phenotypemortality/agingcellular phenotypecardiovascular system phenotypehomeostasis/metabolism phenotyperespiratory system phenotypeintegument phenotypereproductive system phenotypevision/eye phenotypehematopoietic system phenotypemortality/agingcellular phenotypecardiovascular system phenotypehomeostasis/metabolism phenotyperespiratory system phenotypeintegument phenotypereproductive system phenotypevision/eye phenotypehematopoietic system phenotypemortality/agingcellular phenotypecardiovascular system phenotypehomeostasis/metabolism phenotyperespiratory system phenotypeintegument phenotypereproductive system phenotypevision/eye phenotypehematopoietic system phenotypemortality/agingcellular phenotypecardiovascular system phenotypehomeostasis/metabolism phenotyperespiratory system phenotypeintegument phenotypereproductive system phenotypevision/eye phenotypehematopoietic system phenotypemortality/agingcellular phenotypecardiovascular system phenotypehomeostasis/metabolism phenotyperespiratory system phenotypeintegument phenotypereproductive system phenotypevision/eye phenotypehematopoietic system phenotypemortality/agingcellular phenotypecardiovascular cardiovascular system phenotypehomeostasis/methomeostasis/metabolism phenotyperespiratory sysrespiratory system phenotypeintegument phenintegument phenotypereproductive syreproductive system phenotypevision/eye phenvision/eye phenotypehematopoietic shematopoietic system phenotypemortality/agingmortality/agingcellular phenotcellular phenotype
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Selplgtm2Rpmc/Selplgtm2Rpmc
Genetic Background: B6.Cg-Selplgtm2Rpmc

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Selplgtm2Rpmc/Selplgtm2Rpmc
Genetic Background: B6.Cg-Selplgtm2Rpmc

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Selplgtm2Rpmc/Selplgtm2Rpmc
Genetic Background: B6.Cg-Selplgtm2Rpmc

 MP:0001245 thick dermal layer "increased depth of the dermis" [J:65033]
Show

Allelic Composition: Selplgtm2Rpmc/Selplgtm2Rpmc
Genetic Background: B6.Cg-Selplgtm2Rpmc

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Selplgtm2Rpmc/Selplgtm2Rpmc
Genetic Background: B6.Cg-Selplgtm2Rpmc

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
Show

Allelic Composition: Pkd2tm2Som/Pkd2+,Pkhd1tm1Gwu/Pkhd1tm1Gwu
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Selplgtm2Rpmc/Selplgtm2Rpmc
Genetic Background: B6.Cg-Selplgtm2Rpmc

Allelic Composition: Mir126atm1.1Cjku/Mir126atm1.1Cjku
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Selplgtm2Rpmc/Selplgtm2Rpmc
Genetic Background: B6.Cg-Selplgtm2Rpmc

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Selplgtm2Rpmc/Selplgtm2Rpmc
Genetic Background: B6.Cg-Selplgtm2Rpmc

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Selplgtm2Rpmc/Selplgtm2Rpmc
Genetic Background: B6.Cg-Selplgtm2Rpmc

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Selplgtm2Rpmc/Selplgtm2Rpmc
Genetic Background: B6.Cg-Selplgtm2Rpmc

Allelic Composition: Mir126atm1.1Cjku/Mir126atm1.1Cjku
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Selplgtm2Rpmc/Selplgtm2Rpmc
Genetic Background: B6.Cg-Selplgtm2Rpmc

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selplgtm2Rpmc/Selplgtm2Rpmc
Genetic Background: B6.Cg-Selplgtm2Rpmc

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Selplgtm2Rpmc/Selplgtm2Rpmc
Genetic Background: B6.Cg-Selplgtm2Rpmc

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Selplgtm2Rpmc/Selplgtm2Rpmc
Genetic Background: B6.Cg-Selplgtm2Rpmc

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Mir126atm1.1Cjku/Mir126atm1.1Cjku
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

 MP:0020316 decreased vascular endothelial cell proliferation "decrease in the expansion rate of any vascular endothelial cell population by cell division" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Selplgtm2Rpmc/Selplgtm2Rpmc
Genetic Background: B6.Cg-Selplgtm2Rpmc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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