ENSMUSG00000066189


Mus musculus

Features
Gene ID: ENSMUSG00000066189
  
Biological name :Cacng3
  
Synonyms : Cacng3 / Q9JJV5 / Voltage-dependent calcium channel gamma-3 subunit
  
Possible biological names infered from orthology : calcium voltage-gated channel auxiliary subunit gamma 3 / O60359
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F2
Gene start: 122670492
Gene end: 122769393
  
Corresponding Affymetrix probe sets: 10557201 (MoGene1.0st)   1450520_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000081664
Ensembl peptide - ENSMUSP00000138495
Ensembl peptide - ENSMUSP00000138755
NCBI entrez gene - 54376     See in Manteia.
MGI - MGI:1859165
RefSeq - NM_019430
RefSeq Peptide - NP_062303
swissprot - Q9JJV5
swissprot - S4R247
swissprot - S4R2R7
Ensembl - ENSMUSG00000066189
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacng3aENSDARG00000058460Danio rerio
 cacng3bENSDARG00000076401Danio rerio
 CACNG3ENSGALG00000038087Gallus gallus
 CACNG3ENSG00000006116Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cacng2 / O88602 / Voltage-dependent calcium channel gamma-2 subunit / Q9Y698* / calcium voltage-gated channel auxiliary subunit gamma 2*ENSMUSG0000001914676
Cacng8 / voltage-dependent calcium channel gamma-8 subunit / Q8WXS5* / calcium voltage-gated channel auxiliary subunit gamma 8*ENSMUSG0000005339559
Cacng4 / Q9JJV4 / Voltage-dependent calcium channel gamma-4 subunit / Q9UBN1* / calcium voltage-gated channel auxiliary subunit gamma 4*ENSMUSG0000002072358
Cacng5 / Q8VHW4 / Voltage-dependent calcium channel gamma-5 subunit / Q9UF02* / calcium voltage-gated channel auxiliary subunit gamma 5*ENSMUSG0000004037325
Cacng7 / P62956 / Voltage-dependent calcium channel gamma-7 subunit / P62955* / calcium voltage-gated channel auxiliary subunit gamma 7*ENSMUSG0000006980625


Protein motifs (from Interpro)
Interpro ID Name
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR008368  Voltage-dependent calcium channel, gamma subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006605 protein targeting IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0019226 transmission of nerve impulse IBA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:2000311 regulation of AMPA receptor activity IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032281 AMPA glutamate receptor complex IEA
 cellular_componentGO:0036477 somatodendritic compartment IDA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IBA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016247 channel regulator activity IBA


Pathways (from Reactome)
Pathway description
Trafficking of AMPA receptors
Phase 0 - rapid depolarisation
Phase 2 - plateau phase
LGI-ADAM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cacna1atm3Hzo/Cacna1a+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Cacna1atm3Hzo/Cacna1a+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Uchl1tm1Dgen/Uchl1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cacna1atm3Hzo/Cacna1a+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cacng2stg/Cacng2stg,Cacng3tm1Ran/Cacng3tm1Ran
Genetic Background: involves: A/J

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cacng2stg/Cacng2stg,Cacng3tm1Ran/Cacng3tm1Ran
Genetic Background: involves: A/J

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacng2stg/Cacng2stg,Cacng3tm1Ran/Cacng3tm1Ran
Genetic Background: involves: A/J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Uchl1tm1Dgen/Uchl1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cacng2stg/Cacng2stg,Cacng3tm1Ran/Cacng3tm1Ran
Genetic Background: involves: A/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020184 Mdm2 / P23804 / E3 ubiquitin-protein ligase Mdm2 / Q00987* / MDM2 proto-oncogene*  / complex
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / complex
 ENSMUSG00000040537 Adam22 / Q9R1V6 / Disintegrin and metalloproteinase domain-containing protein 22 / Q9P0K1* / ADAM metallopeptidase domain 22*  / complex
 ENSMUSG00000025964 Adam23 / Q9R1V7 / Disintegrin and metalloproteinase domain-containing protein 23 / O75077* / ADAM metallopeptidase domain 23*  / complex / reaction
 ENSMUSG00000067242 Lgi1 / Q9JIA1 / Leucine-rich glioma-inactivated protein 1 / O95970* / leucine rich glioma inactivated 1*  / complex / reaction






 

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