ENSMUSG00000066324


Mus musculus

Features
Gene ID: ENSMUSG00000066324
  
Biological name :Impad1
  
Synonyms : Impad1 / Inositol monophosphatase 3 / Q80V26
  
Possible biological names infered from orthology : inositol monophosphatase domain containing 1 / Q9NX62
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A1
Gene start: 4762484
Gene end: 4793355
  
Corresponding Affymetrix probe sets: 10511368 (MoGene1.0st)   1437288_at (Mouse Genome 430 2.0 Array)   1437289_at (Mouse Genome 430 2.0 Array)   1437290_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000082013
NCBI entrez gene - 242291     See in Manteia.
MGI - MGI:1915720
RefSeq - NM_177730
RefSeq Peptide - NP_808398
swissprot - Q80V26
Ensembl - ENSMUSG00000066324
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 impad1ENSDARG00000058114Danio rerio
 IMPAD1ENSGALG00000041573Gallus gallus
 IMPAD1ENSG00000104331Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bpnt1 / Q9Z0S1 / 3(2),5-bisphosphate nucleotidase 1 / O95861*ENSMUSG0000002661724


Protein motifs (from Interpro)
Interpro ID Name
 IPR000760  Inositol monophosphatase-like
 IPR020550  Inositol monophosphatase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001958 endochondral ossification IMP
 biological_processGO:0002063 chondrocyte development IMP
 biological_processGO:0006021 inositol biosynthetic process IEA
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030204 chondroitin sulfate metabolic process IMP
 biological_processGO:0042733 embryonic digit morphogenesis IMP
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0008254 3"-nucleotidase activity IDA
 molecular_functionGO:0008441 3"(2"),5"-bisphosphate nucleotidase activity IEA
 molecular_functionGO:0008934 inositol monophosphate 1-phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0052832 inositol monophosphate 3-phosphatase activity IEA
 molecular_functionGO:0052833 inositol monophosphate 4-phosphatase activity IEA
 molecular_functionGO:0052834 inositol monophosphate phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Cytosolic sulfonation of small molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000071 axial skeleton hypoplasia "reduced cell number in the skeletal elements of the trunk" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:55583]
Show

Allelic Composition: Mavstm1Aki/Mavstm1Aki,Ifna6tm1Aki/Ifna6+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mavstm1Aki/Mavstm1Aki,Ifna6tm1Aki/Ifna6+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0000435 shortened head "reduced anterior-posterior length of the head" [J:42035]
Show

Allelic Composition: Mavstm1Aki/Mavstm1Aki,Ifna6tm1Aki/Ifna6+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: Mavstm1Aki/Mavstm1Aki,Ifna6tm1Aki/Ifna6+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mavstm1Aki/Mavstm1Aki,Ifna6tm1Aki/Ifna6+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mavstm1Aki/Mavstm1Aki,Ifna6tm1Aki/Ifna6+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itm2btm1.1Ldad/Itm2b+,Tg(APPswe,PSEN1dE9)85Dbo/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mavstm1Aki/Mavstm1Aki,Ifna6tm1Aki/Ifna6+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mavstm1Aki/Mavstm1Aki,Ifna6tm1Aki/Ifna6+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0004340 short scapula "reduced length of either or both of the large, flat bones of the back part of the shoulder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0004355 short radius "reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mavstm1Aki/Mavstm1Aki,Ifna6tm1Aki/Ifna6+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0004672 short ribs "reduced length of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0006397 disorganized long bone epiphyseal plate "a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mavstm1Aki/Mavstm1Aki,Ifna6tm1Aki/Ifna6+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Mavstm1Aki/Mavstm1Aki,Ifna6tm1Aki/Ifna6+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0030245 round head "overall shape of the head is more circular than usual as viewed from the front" [MGI:anna]
Show

Allelic Composition: Mavstm1Aki/Mavstm1Aki,Ifna6tm1Aki/Ifna6+
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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