ENSMUSG00000066595


Mus musculus

Features
Gene ID: ENSMUSG00000066595
  
Biological name :Flvcr1
  
Synonyms : B2RXV4 / Feline leukemia virus subgroup C receptor-related protein 1 / Flvcr1
  
Possible biological names infered from orthology : feline leukemia virus subgroup C cellular receptor 1 / Q9Y5Y0
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H6
Gene start: 191005847
Gene end: 191026158
  
Corresponding Affymetrix probe sets: 10361065 (MoGene1.0st)   10361075 (MoGene1.0st)   1425399_at (Mouse Genome 430 2.0 Array)   1434424_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000082777
Ensembl peptide - ENSMUSP00000141985
Ensembl peptide - ENSMUSP00000141578
NCBI entrez gene - 226844     See in Manteia.
MGI - MGI:2444881
RefSeq - NM_001081259
RefSeq - NM_198025
RefSeq - NM_001313747
RefSeq Peptide - NP_932142
RefSeq Peptide - NP_001074728
RefSeq Peptide - NP_001300676
swissprot - B2RXV4
swissprot - A0A0A6YWJ7
swissprot - A0A0A6YXG8
Ensembl - ENSMUSG00000066595
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 flvcr1ENSDARG00000031587Danio rerio
 FLVCR1ENSGALG00000009807Gallus gallus
 FLVCR1ENSG00000162769Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Flvcr2 / feline leukemia virus subgroup C cellular receptor family member 2 / Q9UPI3*ENSMUSG0000003425848
Dirc2 / Q8BFQ6 / Disrupted in renal carcinoma / Q96SL1* / disrupted in renal carcinoma 2*ENSMUSG0000002284822
Q8CE47 / Mfsd7a / Major facilitator superfamily domain-containing protein 7 / Q6UXD7* / SLC49A3* / solute carrier family 49 member 3*ENSMUSG0000002949022


Protein motifs (from Interpro)
Interpro ID Name
 IPR011701  Major facilitator superfamily
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006839 mitochondrial transport IEA
 biological_processGO:0015886 heme transport IEA
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0035108 limb morphogenesis IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0042733 embryonic digit morphogenesis IMP
 biological_processGO:0043249 erythrocyte maturation IEA
 biological_processGO:0046620 regulation of organ growth IMP
 biological_processGO:0048536 spleen development IMP
 biological_processGO:0048704 embryonic skeletal system morphogenesis IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060323 head morphogenesis IMP
 biological_processGO:0097037 heme export IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0015232 heme transporter activity IEA


Pathways (from Reactome)
Pathway description
Iron uptake and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000087 absent mandible "missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

Allelic Composition: Flvcr1tm1.1Jlab/Flvcr1tm1.1Jlab
Genetic Background: B6.129S4-Flvcr1tm1.1Jlab

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

Allelic Composition: Flvcr1tm1Jlab/Flvcr1tm1Jlab,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Flvcr1tm1Jlab/Flvcr1tm1Jlab,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Flvcr1tm1.1Jlab/Flvcr1tm1.1Jlab
Genetic Background: B6.129S4-Flvcr1tm1.1Jlab

 MP:0006280 abnormal digit development "anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Flvcr1tm1Jlab/Flvcr1tm1Jlab,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Flvcr1tm1Etol/Flvcr1tm1Etol
Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6)

 MP:0008941 reticulocytopenia "decrease in the normal number of circulating reticulocytes" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0008945 hyperchromic macrocytic anemia "deficiency of red blood cells in which the remaining circulating erythrocyte corpuscular volume is larger than normal and the total amount of hemoglobin per cell is increased, but the percentage of hemoglobin per cell is usually in the normochromic range" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Flvcr1tm1Etol/Flvcr1tm1Etol
Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6)

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Flvcr1tm1Jlab/Flvcr1tm1Jlab,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Flvcr1tm1.1Jlab/Flvcr1tm1.1Jlab
Genetic Background: B6.129S4-Flvcr1tm1.1Jlab

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Flvcr1tm1Jlab/Flvcr1tm1Jlab,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0030026 small Meckel s cartilage "reduced size of the cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible and gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [MGI:anna]
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Allelic Composition: Flvcr1tm1Etol/Flvcr1tm1Etol
Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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