ENSMUSG00000068154


Mus musculus

Features
Gene ID: ENSMUSG00000068154
  
Biological name :Insm1
  
Synonyms : Insm1 / Insulinoma-associated protein 1 / Q63ZV0
  
Possible biological names infered from orthology : INSM transcriptional repressor 1 / Q01101
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: G1
Gene start: 146221921
Gene end: 146225020
  
Corresponding Affymetrix probe sets: 10476814 (MoGene1.0st)   1421399_at (Mouse Genome 430 2.0 Array)   1455865_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000092048
NCBI entrez gene - 53626     See in Manteia.
MGI - MGI:1859980
RefSeq - NM_016889
RefSeq Peptide - NP_058585
swissprot - Q05BD7
swissprot - Q63ZV0
Ensembl - ENSMUSG00000068154
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 INSM1ENSG00000173404Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Insm2 / Q9JMC2 / Insulinoma-associated protein 2 / Q96T92* / INSM transcriptional repressor 2*ENSMUSG0000004544039


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0003309 type B pancreatic cell differentiation IDA
 biological_processGO:0003310 pancreatic A cell differentiation IDA
 biological_processGO:0003323 type B pancreatic cell development IMP
 biological_processGO:0003358 noradrenergic neuron development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0031018 endocrine pancreas development TAS
 biological_processGO:0035270 endocrine system development IMP
 biological_processGO:0042421 norepinephrine biosynthetic process IMP
 biological_processGO:0043254 regulation of protein complex assembly ISS
 biological_processGO:0045597 positive regulation of cell differentiation IMP
 biological_processGO:0060290 transdifferentiation ISO
 biological_processGO:0061104 adrenal chromaffin cell differentiation IMP
 biological_processGO:0061549 sympathetic ganglion development IMP
 biological_processGO:0071158 positive regulation of cell cycle arrest IEA
 biological_processGO:2000179 positive regulation of neural precursor cell proliferation IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030332 cyclin binding IEA
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Fgf10tm1Wss/Fgf10tm1Wss
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Insm1tm1Cbm/Insm1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Fgf10tm1Wss/Fgf10tm1Wss
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Insm1tm1Cbm/Insm1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fgf10tm1Wss/Fgf10tm1Wss
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Insm1tm1Cbm/Insm1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003816 abnormal pituitary gland development "malformation or incomplete differentiation of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:51160]
Show

Allelic Composition: Insm1tm1Cbm/Insm1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0003972 decreased pituitary hormone level "less than the expected amount of any of the pituitary hormones in the blood or tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Aspmtm1.2Kxi/Aspmtm1.2Kxi
Genetic Background: involves: C57BL * C57BL/6J * DBA

Allelic Composition: Insm1tm1Cbm/Insm1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0004141 abnormal enteroendocrine cell morphology "malformation of the somatostatin and gastrin secreting epithelial cells present throughout the epithelium of the digestive tract" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf10tm1Wss/Fgf10tm1Wss
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005128 decreased adrenocorticotropin level "decreased concentration of adrenocorticotropic hormone " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aspmtm1.2Kxi/Aspmtm1.2Kxi
Genetic Background: involves: C57BL * C57BL/6J * DBA

Allelic Composition: Insm1tm1Cbm/Insm1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0005130 decreased follicle stimulating hormone level "less than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aspmtm1.2Kxi/Aspmtm1.2Kxi
Genetic Background: involves: C57BL * C57BL/6J * DBA

Allelic Composition: Insm1tm1Cbm/Insm1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0005132 decreased luteinizing hormone level "lower than normal concentration of LH " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aspmtm1.2Kxi/Aspmtm1.2Kxi
Genetic Background: involves: C57BL * C57BL/6J * DBA

Allelic Composition: Insm1tm1Cbm/Insm1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0005134 decreased thyroid-stimulating hormone level "less than expected concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aspmtm1.2Kxi/Aspmtm1.2Kxi
Genetic Background: involves: C57BL * C57BL/6J * DBA

Allelic Composition: Insm1tm1Cbm/Insm1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0005136 decreased growth hormone level "less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aspmtm1.2Kxi/Aspmtm1.2Kxi
Genetic Background: involves: C57BL * C57BL/6J * DBA

Allelic Composition: Insm1tm1Cbm/Insm1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0005138 decreased prolactin level "less than expected concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aspmtm1.2Kxi/Aspmtm1.2Kxi
Genetic Background: involves: C57BL * C57BL/6J * DBA

Allelic Composition: Insm1tm1Cbm/Insm1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0005361 small pituitary gland "reduced size of the pituitary gland, the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Insm1tm1Cbm/Insm1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0006208 embryonic lethality throughout fetal growth and development "death anytime after the completion of organogenesis but before E18.5 (E14 to less than E18.5)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0008330 absent somatotrophs "absence of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [CL:0000295, MESH:A06.407.747.608.937]
Show

Allelic Composition: Insm1tm1Cbm/Insm1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0008339 absent thyrotrophs "absence of an anterior pituitary cell that produces thyroid-stimulating hormone" [MESH:A06.407.747.608.968]
Show

Allelic Composition: Insm1tm1Cbm/Insm1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0008789 abnormal olfactory epithelium morphology "any structural anomaly in the epithelial cells that line the interior of the nose" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0009165 abnormal endocrine pancreas morphology "any structural anomaly of the smaller portion of the pancreas that secretes a number of hormones into the blood stream that are produced by the cells in the islets of Langerhans" [MESH:A03.734]
Show

Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0009169 pancreatic islet hypoplasia "underdevelopment or decreased size of the clusters of hormone-producing cells that are scattered throughout the pancreas, usually due an decreased number of cells" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Fgf10tm1Wss/Fgf10tm1Wss
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009177 decreased pancreatic alpha cell number "reduction in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
Show

Allelic Composition: Fgf10tm1Wss/Fgf10tm1Wss
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009181 decreased pancreatic delta cell number "reduced number of the cells found in the pancreas that secrete somatostatin" [MESH:A03.556.875.875.440.854]
Show

Allelic Composition: Fgf10tm1Wss/Fgf10tm1Wss
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009185 increased PP cell number "increased number of the polygonal pancreatic polypeptide producing cells in the islets of Langerhans in the pancreas" [CL:0000696, MESH:A03.734.414.587]
Show

Allelic Composition: Fgf10tm1Wss/Fgf10tm1Wss
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009187 absent PP cells "absence of the polygonal pancreatic polypeptide producing cells in the islets of Langerhans in the pancreas" [CL:0000696, MESH:A03.734.414.587]
Show

Allelic Composition: Fgf10tm1Wss/Fgf10tm1Wss
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009191 decreased pancreatic epsilon cell number "reduction in the number of the endocrine cells found in the Islets of Langerhans that produce the hormone ghrelin" [PMID:14970313]
Show

Allelic Composition: Fgf10tm1Wss/Fgf10tm1Wss
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Fgf10tm1Wss/Fgf10tm1Wss
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Insm1tm1Cbm/Insm1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Fgf10tm1Wss/Fgf10tm1Wss
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Insm1tm1Cbm/Insm1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0011400 complete lethality "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]
Show

Allelic Composition: Ntrk2tm1Mini/Ntrk2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011910 decreased pancreatic endocrine progenitor cell proliferation "reduced ability of a pancreatic endocrine progenitor cell population to undergo expansion by cell division" [MGI:csmith]
Show

Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0011911 abnormal pancreatic endocrine progenitor cell physiology "any functional anomaly of a multi-fate stem cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells" [CL:0002351]
Show

Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0011932 abnormal endocrine pancreas development 
Show

Allelic Composition: Fgf10tm1Wss/Fgf10tm1Wss
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Insm1tm1.1Mgn/Insm1tm1.1Mgn
Genetic Background: involves: 129S6/SvEvTac * CD-1 * SJL

 MP:0013220 increased pancreas apoptosis "increase in the number of cells of the pancreas undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Fgf10tm1Wss/Fgf10tm1Wss
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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